| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M408986-1ml |
1ml |
现货  |
|
| 英文别名 | Org3770 | 1,2,3,4,10,14b-hexahydro-2-methyl-pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Mirtazapine |
| 生化机理 | 米氮平（Org3770）是一种肾上腺素能和血清素受体拮抗剂，用于治疗抑郁症。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 拮抗剂 |
| 作用机制 | 肾上腺素能受体 alpha-2 拮抗剂 |
| 产品介绍 |
Mirtazapine 是一种有效的四环抗抑郁剂。A potent SR-2, SR-3, and Histamine H1 receptor antagonist. Information Mirtazapine Mirtazapine (Org3770) is an adrenergic and seroton receptor antagonist, used to treat depression. Mirtazapine displays marked affinity for cloned, human alpha2A-adrenergic (AR) receptors at which it blocks noradrenaline (NA)-induced stimulation of guanosine-5\'-O-(3-[35S]thio)-triphosphate ([35S]-GTPgammaS) binding. Mirtazapine shows high affinity for cloned, human serotonin (5-HT)2C receptors at which it abolishes 5-HT-induced phosphoinositide generation. Mirtazapine markedly elevates dialysate levels of NA and, in FCX, DA, whereas 5-HT is not affected. Mirtazapine enhances the effectiveness of the electrical stimulation of the ascending 5-HT pathway by blocking both alpha-2 adrenergic auto- and heteroreceptors. Mirtazapine blocks the suppressant effect of microiontophoretically applied norepinephrine (NE) on the firing activity of CA3 dorsal hippocampus pyramidal neurons, indicating their antagonistic effects on postsynaptic alpha-2 adrenoceptors. In vivo Mirtazapine (10-250 mg/kg i.v.) enhances dose-dependently the firing activity of the 5-HT neurons in naive rats, but not in 6-hydroxydopamine-pretreated rats. Mirtazapine (5 mg/kg/day, s.c., using osmotic minipumps) increases the spontaneous firing activity of locus coeruleus noradrenaline (NA) neurons in male Sprague-Dawley rats. Mirtazapine antagonizes both the enhancing effect of a low dose (10 mg/kg, i.v.) and the reducing effect of a high dose (100 mg/kg, i.v.) of the alpha 2-adrenoceptor agonist clonidine on the effectiveness of the electrical stimulation of the ascending 5-HT pathway in suppressing the firing activity of dorsal hippocampus CA3 pyramidal neurons. Mirtazapine (5 mg/kg s.c.) only slightly affects DOPAC and homovanillic acid levels in the striatum, hardly affects 5-HT release in freely moving rats, but clearly increased 5-hydroxyindole acetic acid. cell lines：46 lymphoma cell lines Concentrations： Incubation Time： Powder Purity:≥99% |
| Isomeric SMILES | CN1CCN2C(C1)C3=CC=CC=C3CC4=C2N=CC=C4 |
|---|---|
| 分子量 | 265.35 |
| Reaxy-Rn | 549345 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=549345&ln= |
| 熔点 | 121 °C |
|---|
| 象形图 | GHS08, GHS09, GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H373: 通过长时间或反复暴露对器官造成损害 H411: 对水生生物有毒并具有长期持续影响 H302: 吞食有害 H336: 可能引起嗜睡或头晕 H361: 怀疑破坏生育力或未出生的孩子 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P391: 收集溢出物 P330: 漱口 P203: 使用前，获取、阅读并遵守所有安全说明。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P318: 如果暴露或担心，请就医。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | UQ4410250 |
| 个人防护装备 | Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter |
| 1. Rongzhe Zhu, Xiaochen Liu, Qiupeng Xue, Xiaoru Dong, Tianyi Zhang, Yan Jiang. (2022) Ethanol potentiates mirtazapine-induced cardiotoxicity by inducing dysfunctional autophagy via HMGB1-dependent Akt/mTOR signaling pathway. TOXICOLOGY LETTERS, 358 (27). [PMID:35066094] [10.1016/j.toxlet.2022.01.008] |
| 2. Danyi Lu, Dong Dong, Baojian Wu. (2018) Highly selective N-glucuronidation of four piperazine-containing drugs by UDP-glucuronosyltransferase 2B10. Expert Opinion on Drug Metabolism & Toxicology, 14 (9): (989-998). [PMID:30049229] [10.1080/17425255.2018.1505862] |
| 3. Danyi Lu, Qian Xie, Baojian Wu. (2017) N-glucuronidation catalyzed by UGT1A4 and UGT2B10 in human liver microsomes: Assay optimization and substrate identification. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 145 (692). [PMID:28803208] [10.1016/j.jpba.2017.07.037] |
| 4. Xiujuan Chen, Shuiqing Zheng, Jian Le, Zheyuan Qian, Runsheng Zhang, Zhanying Hong, Yifeng Chai. (2017) Ultrasound-assisted low-density solvent dispersive liquid–liquid microextraction for the simultaneous determination of 12 new antidepressants and 2 antipsychotics in whole blood by gas chromatography–mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 142 (19). [PMID:28494335] [10.1016/j.jpba.2017.04.032] |
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