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甘油单油酸酯, GPR119 的激动剂

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
M395915-100mg
100mg 现货 Stock Image
M395915-500mg
500mg 现货 Stock Image

基本描述

别名 油酸甘油酯,单油酸甘油酯,1-油酰基-rac-甘油 | 1-(顺-9- 十八烯酰基)-rac-甘油 | rac-甘油 1-单油酸酯 | DL-α-甘油单油酸酯 | 甘油顺-9-十八烯酰基
英文别名 1-Oleylglycerol | alpha-Monoolein | Excel O 95F | Oleoyl glycerol | 1-Monooleoyl-rac-glycerol | CHEBI:75342 | Emery oleic acid ester 2221 | Nikkol MGO | rac-1-Monoolein | Monoolein | mono-olein | 1,2,3-Propanetriol mono((Z)-9-octadecenoate) | 2,3-dihydrox
规格或纯度 Moligand™, ≥95%
英文名称 Monoolein
生化机理 甘油单油酸酯(1-油酰-rac-甘油)被用来研发基于甘油单油酸酯的纳米颗粒液体分散剂,作为潜在的给药载体。
储存温度 -20°C储存,充氩
运输条件 超低温冰袋运输
作用类型 激动剂
作用机制 GPR119 的激动剂
产品介绍


1-Oleoyl-rac-glycerol is a monoglyceride, obtained from natural oils and fats. It contains two alcohol groups that are reactive. It is soluble in chloroform and hexane. It can be crystallized from hexane.

纯度 ≥95%

关联靶点(人)

GPR119 Tclin 葡萄糖依赖性胰岛素促泌剂受体(Glucose-dependent insulinotropic receptor) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PLA2G2A Tchem Phospholipase A2 group IIA (1079 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

EC号 203-809-9
分子类型 小分子
IIUPAC Name 2,3-dihydroxypropyl (Z)-octadec-9-enoate
INCHI 1S/C21H40O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)25-19-20(23)18-22/h9-10,20,22-23H,2-8,11-19H2,1H3/b10-9-
InChi Key RZRNAYUHWVFMIP-KTKRTIGZSA-N
Smiles CCCCCCCCC=CCCCCCCCC(=O)OCC(CO)O
Isomeric SMILES CCCCCCCC/C=C\CCCCCCCC(=O)OCC(CO)O
分子量 356.54
Beilstein号 1728976
Reaxy-Rn 1728976
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1728976&ln=

化学和物理性质

密度 0.969
敏感性 对光线敏感 ;对空气敏感 ;对湿度敏感
闪点(℉) 309.2 °F
闪点(℃) 154 °C
熔点 35-37°C
分子量 356.500 g/mol
XLogP3 6.500
氢键供体数Hydrogen Bond Donor Count 2
氢键受体数Hydrogen Bond Acceptor Count 4
可旋转键计数Rotatable Bond Count 19
精确质量Exact Mass 356.293 Da
单同位素质量Monoisotopic Mass 356.293 Da
拓扑极表面积Topological Polar Surface Area 66.800 Ų
重原子数Heavy Atom Count 25
形式电荷Formal Charge 0
复杂度Complexity 315.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 1
定义的键立体中心计数Defined Bond Stereocenter Count 1
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 1
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性(GHS)

信号词 Warning
危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激

H412: 对水生生物有害并具有长期持续影响

H302: 吞食有害

预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。

P273: 避免释放到环境中。

WGK Germany 1
个人防护装备 Faceshields,full-face respirator (US),Gloves,Goggles,multi-purpose combination respirator cartridge (US),type ABEK (EN14387) respirator filter

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找到8个结果

批号(Lot Number) 证书类型 货号
G2516376 分析证书 M395915
G2516378 分析证书 M395915
G2516385 分析证书 M395915
G2516384 分析证书 M395915
H2111380 分析证书 M395915
H2111381 分析证书 M395915
K2212281 分析证书 M395915
K2212283 分析证书 M395915

此产品的引用文献

引用文献

1. Yingzhu Zhang, Jinqi Xu, Cuie Tang, Yan Li.  (2023)  Crystallization Behavior and Physical Properties of Monoglycerides-Based Oleogels as Function of Oleogelator Concentration.  Foods,  12  (2): (345).  [PMID:36673437] [10.3390/foods12020345]
2. Qingqing Xu, Xiaoli Qin, Dongming Lan, Xuan Liu, Bo Yang, Sentai Liao, Weifei Wang, Yonghua Wang.  (2022)  Water-in-oil emulsions enriched with alpha-linolenic acid in diacylglycerol form: Stability, formation mechanism and in vitro digestion analysis.  FOOD CHEMISTRY,  391  (133201).  [PMID:35609461] [10.1016/j.foodchem.2022.133201]
3. Fu Fangqin, Li Xin, Zheng Tengyi, Xia Xiao, Du Minqun, Huang Zhengwei, Huang Ying, Pan Xin, Wu Chuanbin.  (2021)  Stability Evaluation of Lyotropic Liquid Crystalline Precursor for the Co-delivery of Chlorhexidine and Silver Nanoparticles.  AAPS PHARMSCITECH,  22  (7): (1-9).  [PMID:34545436] [10.1208/s12249-021-02102-x]
4. Weiwei Wang, Zhuangzhuang Liu, Qimin Song, Xindi Zhang, Shengkai Jiao, Yao Xu, Quanda Xu, Dezun Sheng.  (2021)  Tribological performance of organic molybdenum in the presence of organic friction modifier.  PLoS One,  16  (6): (e0252203).  [PMID:34111128] [10.1371/journal.pone.0252203]
5. Yajing Hu, Zhenxia Du, Xuechun Sun, Xin Ma, Jingdan Song, Haixia Sui, Augustine Atta Debrah.  (2021)  Non-targeted analysis and risk assessment of non-volatile compounds in polyamide food contact materials.  FOOD CHEMISTRY,  345  (128625).  [PMID:33601649] [10.1016/j.foodchem.2020.128625]
6. Xiao-Wei Chen, Shang-De Sun, Guo-Long Yang, Chuan-Guo Ma.  (2019)  Engineering phytosterol-based oleogels for potential application as sustainable petrolatum replacement.  RSC Advances,  10  (1): (244-252).  [PMID:35492564] [10.1039/C9RA06950J]
7. Shangde Sun, Xuebei Hou.  (2019)  A novel caffeic acid-based deep eutectic solvent as caffeoyl donor to enhance glycerol caffeates synthesis.  JOURNAL OF MOLECULAR LIQUIDS,  277  (556).  [10.1016/j.molliq.2018.12.145]
8. Tengyi Zheng, Xintian Huang, Jintian Chen, Disang Feng, Liling Mei, Ying Huang, Guilan Quan, Chune Zhu, Vikramjeet Singh, Hao Ran, Xin Pan, Chuan-Yu Wu, Chuanbin Wu.  (2018)  A liquid crystalline precursor incorporating chlorhexidine acetate and silver nanoparticles for root canal disinfection.  Biomaterials Science,  (3): (596-603).  [PMID:29406548] [10.1039/C7BM00764G]
9. Han Lidong, Yang Rong, Yuan Shengxiao, Ding Shuang, Wu Ziheng, Wu Zhenghong, Qi Xiaole.  (2018)  Soft multiple emulsions demonstrating reversible freeze-thawing capacity and enhanced skin permeability of diclofenac sodium.  COLLOID AND POLYMER SCIENCE,  296  (3): (471-481).  [10.1007/s00396-018-4265-3]
10. Xuan Liu, Chunjin Huang, Dongming Lan, Weifei Wang, Yonghua Wang.  (2025)  Combining phospholipase A1 with monoacylglycerol lipase for crude vegetable oil degumming through improved oil-water separation.  FOOD CHEMISTRY,  467  (142366).  [PMID:39644657] [10.1016/j.foodchem.2024.142366]
11. Siliang Ding, Xiaohan Chen, Bo Ouyang, Bo Yang, Weifei Wang, Yonghua Wang.  (2024)  Exploring Diacylglycerol Oil-Based Oleogels as Effective Stabilizers in Peanut Butter: Performance, Structural Insights, and Sensory Evaluation.  Journal of Oleo Science,  [PMID:38311404] [10.5650/jos.ess23122]
12. Ruirui Li, Wei Zhuang, Yan Gao, Yahan Bai, Keke Zhang, Zhenfu Wang.  (2025)  Interfacial modulation of hierarchically porous UIO-66 for the immobilization of Rhizomucor miehei lipase towards the efficient synthesis of 1,3-dioleic acid glycerol.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  291  (138993).  [PMID:39710037] [10.1016/j.ijbiomac.2024.138993]
13. Bowen Yang, Tian Zhao, Shengyang Ji, Yan Liu, Minghao Xu, Baiyi Lu.  (2024)  Molecular dynamics simulations of the interfacial behaviors and photo-oxidation of phytosterol under different emulsion oil content.  FOOD CHEMISTRY,  451  (139292).  [PMID:38663239] [10.1016/j.foodchem.2024.139292]
14. Huijing Chen, Shanliang Zhong, Guoxiang Chi, Huiying Li, Kewei Chen, Zhirong Wang, Jianquan Kan.  (2025)  Preparation and functional characteristics of starch-lipid complexes with different oleic acid-rich glycerolipids.  FOOD CHEMISTRY,  476  (143450).  [PMID:39986078] [10.1016/j.foodchem.2025.143450]

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