| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M299661-500μl |
500μL |
现货  |
|
| 别名 | 生物毒素, 蓝藻毒素, 藻华毒素,快速死亡因子 |
|---|---|
| 英文别名 | Cyanoginosin LR | Toxin-LR | Toxin I (Microcystis aeruginosa) |
| 规格或纯度 | Moligand™, ~10ug/ml in Methanol/Water(1/1) |
| 英文名称 | Microcystin-LR (MCYST-LR) |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
微囊藻毒素-LR属于环状七肽代谢产物微囊藻毒素类，由蓝绿藻铜绿微囊藻和其它藻类产生。 Product introduction： Microcystins are toxic molecules produced by cyanobacterial blooms due to water eutrophication. Microcystin-LR proves to be a potent inhibitor of type 1 (IC50=1.7 nM) and type 2A (IC50= 0.04 nM) protein phosphatases. Microcystin-LR inhibits the activity of both type 1 and type 2A phosphatases >10-fold more potently than okadaic acid under the same conditions. Type 2A protein phosphatases in dilute mammalian cell extracts are found to be completely inhibited by 0.5 nM microcystin-LR while type 1 protein phosphatases are only slightly affected at this concentration. Application： Microcystin-LR may be used as an analytical reference standard for the determination of the analyte in surface water samples using high-performance liquid chromatography coupled to tandem mass spectrometry with electrospray ionization source (HPLC-ESI-MS/MS). |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 621-323-9 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | (5R,8S,11R,12S,15S,18S,19S,22R)-15-[3-(diaminomethylideneamino)propyl]-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,5,12,19-tetramethyl-2-methylidene-8-(2-methylpropyl)-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptazacyclopentacosane-11,22-dicarboxylic acid |
| INCHI | 1S/C49H74N10O12/c1-26(2)23-37-46(66)58-40(48(69)70)30(6)42(62)55-35(17-14-22-52-49(50)51)45(65)54-34(19-18-27(3)24-28(4)38(71-10)25-33-15-12-11-13-16-33)29(5)41(61)56-36(47(67)68)20-21-39(60)59(9)32(8)44(64)53-31(7)43(63)57-37/h11-13,15-16,18-19,24,26,28-31,34-38,40H,8,14,17,20-23,25H2,1-7,9-10H3,(H,53,64)(H,54,65)(H,55,62)(H,56,61)(H,57,63)(H,58,66)(H,67,68)(H,69,70)(H4,50,51,52)/b19-18+,27-24+/t28-,29-,30-,31+,34-,35-,36+,37-,38-,40+/m0/s1 |
| InChi Key | ZYZCGGRZINLQBL-GWRQVWKTSA-N |
| Smiles | CC1C(NC(=O)C(NC(=O)C(C(NC(=O)C(NC(=O)C(NC(=O)C(=C)N(C(=O)CCC(NC1=O)C(=O)O)C)C)CC(C)C)C(=O)O)C)CCCN=C(N)N)C=CC(=CC(C)C(CC2=CC=CC=C2)OC)C |
| Isomeric SMILES | C[C@H]1[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(=C)N(C(=O)CC[C@@H](NC1=O)C(=O)O)C)C)CC(C)C)C(=O)O)C)CCCN=C(N)N)/C=C/C(=C/[C@H](C)[C@H](CC2=CC=CC=C2)OC)/C |
| 关联CAS | 101043-37-2 |
| NSC Number | 733608 |
| MeSH Entry Terms | cyanoginosin LR;cyanoginosin-lr;cyclo(2,3-didehydro-n-methylalanyl-D-alanyl-l-leucyl-erythro-3-methyl-D-beta-aspartyl-l-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-d-gamma-glutamyl);cyclo(Ala-Leu-MA |
| 分子量 | 995.17 |
| Reaxy-Rn | 30146673 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30146673&ln= |
| 敏感性 | 对热敏感 |
|---|---|
| 分子量 | 995.200 g/mol |
| XLogP3 | 2.300 |
| 氢键供体数Hydrogen Bond Donor Count | 10 |
| 氢键受体数Hydrogen Bond Acceptor Count | 13 |
| 可旋转键计数Rotatable Bond Count | 15 |
| 精确质量Exact Mass | 994.549 Da |
| 单同位素质量Monoisotopic Mass | 994.549 Da |
| 拓扑极表面积Topological Polar Surface Area | 343.000 Ų |
| 重原子数Heavy Atom Count | 71 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 2000.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 10 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 2 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 2 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS02, GHS06, GHS08 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H225: 高度易燃的液体和蒸气 H301+H311: 吞咽或皮肤接触可致中毒。 H301+H331: 吞咽或吸入可致中毒。 |
| 预防措施声明 |
P210: 远离热源，热表面，火花，明火和其他点火源。 - 禁止抽烟。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P311: 打电话给毒物中心或医生。。。 P312: 打电话给毒物中心或医生。。。如果你觉得不舒服 P301+P330+P331: 如误吞咽：漱口。不要诱导呕吐。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 |
| WGK Germany | WGK 2 |
| 个人防护装备 | Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US) |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
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