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1-(2-甲氧苯基)哌嗪

COA COA
    级别和纯度:
  • ≥98%(GC)
有货

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货号 (SKU) 包装规格 是否现货 价格 数量
M133397-5g
 5g 现货 Stock Image
M133397-25g
 25g 现货 Stock Image
M133397-100g
 100g 现货 Stock Image
M133397-500g
 500g 现货 Stock Image
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六元杂环化合物 (1701) 哌嗪类 (424)
main product photo

基本描述

别名 2-(1-哌嗪基)苯甲醚
英文别名 1-(2'-methoxyphenyl)piperazine | 1-(2-Methoxyphenyl)piperazine | 1-(2-methoxy-phenyl)piperazine | 1-(2-Methoxy-phenyl)-piperazine | 1-(2-Methoxyphenyl)-piperazine | AKOS000101051 | 4-(2-methoxyphenyl)piperazine | 4-(2-methoxyphenyl)-piperazine | Spectrum_
规格或纯度 ≥98%(GC)
英文名称 1-(2-Methoxyphenyl)piperazine
储存温度 2-8°C储存,充氩
运输条件 冰袋运输
产品介绍

产品应用：

1-(2-甲氧苯基)哌嗪可用于：通过Aza-Michael加成反应官能化吡唑乙烯酮 (pyrazolylvinyl ketone) 类化合物。制备环胺取代Tröger碱衍生物。与[(1-甲基-2-巯基咪唑-5-基)羰基]琥珀酰亚胺反应，制备官能化双(巯基咪唑)硼酸酯。
纯度 ≥98%(GC)

关联靶点（人）

HTR6 Tchem 5-羟色胺受体 6(5-hydroxytryptamine receptor 6) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
ADRB2 Tclin Beta-2 adrenergic receptor (11824 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR6 Tchem Serotonin 6 (5-HT6) receptor (9749 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HEK293 (82097 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ATXN2 Tbio Ataxin-2 (54410 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Htr7 Serotonin 7 (5-HT7) receptor (19 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Sigmar1 Sigma opioid receptor (160 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Adra1b Adrenergic receptor alpha-1 (5652 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Adra2c Adrenergic receptor alpha-2 (3313 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Htr2b Serotonin 2 (5-HT2) receptor (2078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Htr3a Serotonin 3 (5-HT3) receptor (1834 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Htr1b Serotonin 1 (5-HT1) receptor (408 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

分子类型 小分子
IIUPAC Name 1-(2-methoxyphenyl)piperazine
INCHI InChI=1S/C11H16N2O/c1-14-11-5-3-2-4-10(11)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3
InChi Key VNZLQLYBRIOLFZ-UHFFFAOYSA-N
Smiles COC1=CC=CC=C1N2CCNCC2
Isomeric SMILES COC1=CC=CC=C1N2CCNCC2
分子量 192.26
Beilstein号 23(3/4)139
Reaxy-Rn 167888
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=167888&ln=

化学和物理性质

溶解性 Soluble in chloroform, ethyl acetate, and methanol. Insoluble in water
敏感性 易吸潮；对空气敏感；对光线敏感
闪点(℉) 230 °F
闪点(℃) 110 °C
熔点 35 °C
分子量 192.260 g/mol
XLogP3 1.400
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 3
可旋转键计数Rotatable Bond Count 2
精确质量Exact Mass 192.126 Da
单同位素质量Monoisotopic Mass 192.126 Da
拓扑极表面积Topological Polar Surface Area 24.500 Ų
重原子数Heavy Atom Count 14
形式电荷Formal Charge 0
复杂度Complexity 169.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS05
信号词 危险
危险声明

H314: 造成严重的皮肤灼伤和眼睛损伤
预防措施声明

P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。

P264: 处理后要彻底洗手。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P321: 特殊处理（请参阅此标签上的...）。

P363: 再次使用之前，请清洗受污染的衣物。

P301+P330+P331: 如误吞咽：漱口。不要诱导呕吐。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P305+P354+P338: 如果进入眼睛：立即用水冲洗几分钟。取下隐形眼镜（如果有的话），并且操作简单。继续冲洗。

P302+P361+P354: 如果接触皮肤：立即脱掉所有被污染的衣服。立即用水冲洗几分钟。

P316: 立即寻求紧急医疗救助。
WGK Germany 3
个人防护装备 Eyeshields， Faceshields， full-face particle respirator type N100 (US)， Gloves， respirator cartridge type N100 (US)， type P1 (EN143) respirator filter， type P3 (EN 143) respirator cartridges

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C of A & Other Certificates(BSE/TSE, COO):
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找到15个结果

批号(Lot Number) 证书类型 货号
I2529297 分析证书 M133397
I2529432 分析证书 M133397
I2529433 分析证书 M133397
I2529434 分析证书 M133397
J2410630 分析证书 M133397
K2224715 分析证书 M133397
K2224723 分析证书 M133397
K2224726 分析证书 M133397
C2421504 分析证书 M133397
C2421505 分析证书 M133397
C2421506 分析证书 M133397
E1723077 分析证书 M133397
K2224719 分析证书 M133397
J2331073 分析证书 M133397
A2431207 分析证书 M133397

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引用文献

1. E Benfenati,S Caccia,F Della Vedova.  (1987-04-01)  1-(o-Methoxyphenyl)piperazine is a metabolite of drugs bearing a methoxyphenylpiperazine side-chain..  The Journal of pharmacy and pharmacology,  39  ((4)): (312-313).  [PMID:2884299]
2. L Pawłowski.  (1983-01-01)  A serotonergic component in the central action of 1-(o-methoxyphenyl)-piperazine..  Polish journal of pharmacology and pharmacy,  35  ((4)): (319-326).  [PMID:6664937]
3. R Perrone,F Berardi,M Leopoldo,V Tortorella,M D Lograno,E Daniele,S Govoni.  (1995-07-01)  5-HT1A and D-2 receptor affinity of o-methoxyphenylpiperazine derivatives with terminal benzamide fragment on N-4 alkyl chain. 2..  Farmaco (Societa chimica italiana : 1989),  50  ((7-8)): (505-510).  [PMID:7669188]
4. P Molander,K Haugland,G Fladseth,E Lundanes,S Thorud,Y Thomassen,T Greibrokk.  (2000-10-25)  Determination of 1-(2-methoxyphenyl)piperazine derivatives of isocyanates at low concentrations by temperature-programmed miniaturized liquid chromatography..  Journal of chromatography. A,  892  ((1-2)): (67-74).  [PMID:11045481]
5. Carl J Sennbro,Jenny Ekman,Christian H Lindh,Hans Welinder,Bo A G Jönsson,Håkan Tinnerberg.  (2004-07-09)  Determination of isocyanates in air using 1-(2-methoxyphenyl)piperazine-impregnated filters: long-term sampling performance and field comparison with impingers with dibutylamine..  The Annals of occupational hygiene,  48  ((5)): (415-424).  [PMID:15240338]
6. Mase Lee,Jagadeesh B Rangisetty,Manik R Pullagurla,Małgorzata Dukat,Vince Setola,Bryan L Roth,Richard A Glennon.  (2005-03-05)  1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands..  Bioorganic & medicinal chemistry letters,  15  ((6)): (1707-1711).  [PMID:15745826]
7. Karen E Warburton,Malcom R Clench,Michael J Ford,John White,Duncan A Rimmer,Vikki A Carolan.  (2005-12-03)  Characterisation of derivatised monomeric and prepolymeric isocyanates by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry and structural elucidation by tandem mass spectrometry..  European journal of mass spectrometry (Chichester, England),  11  ((6)): (565-574).  [PMID:16322663]
8. Hartmut Henneken,Heiko Hayen,Martin Vogel,Uwe Karst.  (2006-09-26)  Validation of a diffusive sampling method for airborne low-molecular isocyanates using 4-nitro-7-piperazinobenzo-2-oxa-1,3-diazole-impregnated filters and liquid chromatography-tandem mass spectrometry..  Journal of chromatography. A,  1134  ((1-2)): (112-121).  [PMID:16996529]
9. Christian Mattsson,Christian H Lindh,Håkan Tinnerberg.  (2007-09-18)  Underestimation of toluene diisocyanate concentration using long-term sampling with 1-(2-methoxyphenyl) piperazine impregnated filters..  International journal of hygiene and environmental health,  211  ((3-4)): (458-462).  [PMID:17869179]
10. Andrzej J Bojarski,Maria J Mokrosz,Beata Duszyńska,Aneta Kozioł,Ryszard Bugno.  (2007-11-17)  New imide 5-HT1A receptor ligands - modification of terminal fragment geometry..  Molecules (Basel, Switzerland),  9  ((3)): (170-177).  [PMID:18007421]
11. Maj-Len Henriks-Eckerman,Erja A Mäkelä,Juha Laitinen,Katriina Ylinen,Katri Suuronen,Aki Vuokko,Riitta Sauni.  (2014-12-30)  Role of dermal exposure in systemic intake of methylenediphenyl diisocyanate (MDI) among construction and boat building workers..  Toxicology letters,  232  ((3)): (595-600).  [PMID:25542146]
12. Liang Meng,Wenwen Zhang,Pinjia Meng,Binling Zhu,Kefang Zheng.  (2015-03-25)  Comparison of hollow fiber liquid-phase microextraction and ultrasound-assisted low-density solvent dispersive liquid-liquid microextraction for the determination of drugs of abuse in biological samples by gas chromatography-mass spectrometry..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  989  (46-53).  [PMID:25801996]
13. Nadia Malek Saied,Najoua Mejri,Radhia El Aissi,Eric Benoist,Mouldi Saidi.  (2015-05-21)  Preparation and biodistribution of 1-((2-methoxyphenyl) piperazine)ferrocenecarboxamide labeled with technetium-99m as a potential brain receptor imaging agent..  European journal of medicinal chemistry,  97  (280-288).  [PMID:25993108]
14. Karolina Klesiewicz, Elżbieta Karczewska, Alicja Budak, Henryk Marona, Natalia Szkaradek,.  (2016-03-31)  Anti-Helicobacter pylori activity of some newly synthesized derivatives of xanthone..  The Journal of antibiotics,  69  ((11)): ( 825-834 ).  [PMID:27025351]
15. Mikolaj Jan Jankowski,Raymond Olsen,Yngvar Thomassen,Paal Molander.  (2017-08-02)  Comparison of air samplers for determination of isocyanic acid and applicability for work environment exposure assessment..  Environmental science. Processes & impacts,  19  ((8)): (1075-1085).  [PMID:28762425]
16. Mehtap Tugrak,Halise Inci Gul,Kenjiro Bandow,Hiroshi Sakagami,Ilhami Gulcin,Yusuf Ozkay,Claudiu T Supuran.  (2019-07-10)  Synthesis and biological evaluation of some new mono Mannich bases with piperazines as possible anticancer agents and carbonic anhydrase inhibitors..  Bioorganic chemistry,  90  (103095-103095).  [PMID:31288135]
17. B Roloff,V Hagen,A Hagen,R Mitzner,H Köppel.  (1989-09-01)  [Potential cardiotonics. 5. Preparation and properties of 6-unsubstituted and 6-methyl-substituted 3-cyan-5-(pyrid-4-yl)pyridine]..  Die Pharmazie,  44  ((9)): (643-644).  [PMID:2608713]
18. D A Bagon,C J Warwick,R H Brown.  (1984-01-01)  Evaluation of total isocyanate-in-air method using 1-(2-methoxyphenyl)piperazine and HPLC..  American Industrial Hygiene Association journal,  45  ((1)): (39-43).  [PMID:6702596]
19. R P Streicher,J E Arnold,M K Ernst,C V Cooper.  (1996-10-01)  Development of a novel derivatization reagent for the sampling and analysis of total isocyanate group in air and comparison of its performance with that of several established reagents..  American Industrial Hygiene Association journal,  57  ((10)): (905-913).  [PMID:8865599]
20. T Ochi,T Goto.  (2000-12-06)  The antinociceptive effect induced by FR140423 is mediated through spinal 5-HT2A and 5-HT3 receptors..  European journal of pharmacology,  409  ((2)): (167-172).  [PMID:11104830]
21. Jan Boksa,Sijka Charakchieva-Minol,Beata Duszyńska,Ryszard Bugno,Aleksandra Kłodzińska,Ewa Tatarczyńska,Ewa Chojnacka-Wójcik,Andrzej J Bojarski.  (2004-01-20)  Synthesis, in vitro and in vivo 5-HT1A/5-HT2A serotonin receptor activity of new hybrid 1,2,3,4-tetrahydro-gamma-carbolines with 1-(2-methoxyphenyl)piperazine moiety..  Polish journal of pharmacology,  55  ((6)): (1013-1019).  [PMID:14730096]
22. Hartmut Henneken,Martin Vogel,Uwe Karst.  (2007-01-24)  Effects of humidity and filter material on diffusive sampling of isocyanates using reagent-coated filters..  Journal of environmental monitoring : JEM,  8  ((10)): (1014-1019).  [PMID:17240907]

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