1-甲基-L-组氨酸

天然非蛋白氨基酸。

2篇引用文献

COA

级别和纯度:

≥98%

CAS编号: 332-80-9
分子式: C₇H₁₁N₃O₂
分子量: 169.2
Beilstein号: 9727
EC号: MFCD00005295
MDL号: MFCD00005295
PubChem编号: 92105
PubChem SID: 504756100

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货号 (SKU)	包装规格	是否现货
M112851-50mg	50mg	现货
M112851-250mg	250mg	现货
M112851-1g	1g	现货

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代谢物 (8911)

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基本描述

英文别名	Fosfamidon \| L-1-Methylhistidine \| 4-Methyl-Histidine \| N1-Methyl-L-histidine \| DB04151 \| Ntau-Methyl-L-histidine \| L-Histidine, 1-methyl- (9CI) \| .TAU.-METHYLHISTIDINE \| AKOS016843072 \| N \| 583O01BJ32 \| EN300-1168703 \| 1-methyl histidine \| 1-Methyl-L-his
规格或纯度	≥98%
英文名称	1-Methyl-L-histidine
生化机理	天然的非蛋白质氨基酸，用作肌肉蛋白质分解的指标。
储存温度	2-8°C储存,充氩
运输条件	冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	天然但非蛋白原氨基酸；用于肌肉蛋白破裂的引发剂。 Natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown. Applications： The urinary 1- and 3-methylhistidine (1- and 3-MH) metabolites as potential biomarkers of skeletal muscle toxicity. These metabolites were highly correlated to sex-, dose-, and time-dependent development of cerivastatin-induced myotoxicity. Natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.
纯度	≥98%

关联靶点（人）

SLC7A5 Tchem L-type amino acid transporter 1 (388 活性数据)

点击查看靶蛋白信息： SLC7A5

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Hdc Histidine decarboxylase (50 活性数据)

点击查看靶蛋白信息： Hdc

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	504756100
EC号	MFCD00005295
分子类型	小分子
IIUPAC Name	(2S)-2-amino-3-(1-methylimidazol-4-yl)propanoic acid
INCHI	1S/C7H11N3O2/c1-10-3-5(9-4-10)2-6(8)7(11)12/h3-4,6H,2,8H2,1H3,(H,11,12)/t6-/m0/s1
InChi Key	BRMWTNUJHUMWMS-LURJTMIESA-N
Smiles	CN1C=C(N=C1)CC(C(=O)O)N
Isomeric SMILES	CN1C=C(N=C1)C[C@@H](C(=O)O)N
分子量	169.2
Beilstein号	9727
Reaxy-Rn	611190
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=611190&ln=

化学和物理性质

溶解性	Methanol (Slightly), Water (Slightly, Sonicated)
密度	1.37
比旋光度	[α]20/D −24±1°, c = 2% in H2O
熔点	240°C
分子量	169.180 g/mol
XLogP3	-3.300
氢键供体数Hydrogen Bond Donor Count	2
氢键受体数Hydrogen Bond Acceptor Count	4
可旋转键计数Rotatable Bond Count	3
精确质量Exact Mass	169.085 Da
单同位素质量Monoisotopic Mass	169.085 Da
拓扑极表面积Topological Polar Surface Area	81.100 Å²
重原子数Heavy Atom Count	12
形式电荷Formal Charge	0
复杂度Complexity	174.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	1
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

WGK Germany	3
个人防护装备	Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

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找到9个结果

批号(Lot Number)	证书类型	货号
D2117275	分析证书	M112851
K2406467	分析证书	M112851
G1922075	分析证书	M112851
J2513130	分析证书	M112851
I2224263	分析证书	M112851
I2224264	分析证书	M112851
I2224265	分析证书	M112851
L2402441	分析证书	M112851
G2214041	分析证书	M112851

此产品的引用文献

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引用文献

1. P Betto,G Ricciarello,S Pichini,L Dello Strologo,G Rizzoni. (1992-12-23) High-performance liquid chromatography-electrochemical detection of 3-methylhistidine in human urine.. Journal of chromatography, 584 ((2)): (256-260). [PMID:1484110]
2. A C McLellan,S A Phillips,P J Thornalley. (1992-10-01) Fluorimetric assay of D-lactate.. Analytical biochemistry, 206 ((1)): (12-16). [PMID:1456422]
3. J A Driskell,B M Chrisley,L K Reynolds,S W Moak. (1991-08-23) Plasma B6 vitamer and plasma and urinary 4-pyridoxic acid concentrations of middle-aged obese black women.. Journal of chromatography, 568 ((2)): (333-340). [PMID:1783639]
4. J Sjölin,H Stjernström,S Henneberg,L Hambraeus,G Friman. (1989-01-01) Evaluation of urinary 3-methylhistidine excretion in infection by measurements of 1-methylhistidine and the creatinine ratios.. The American journal of clinical nutrition, 49 ((1)): (62-70). [PMID:2912013]
5. H E Meyer,G W Mayr. (1987-12-01) N pi-methylhistidine in myosin-light-chain kinase.. Biological chemistry Hoppe-Seyler, 368 ((12)): (1607-1611). [PMID:3442604]
6. J R Bales,D P Higham,I Howe,J K Nicholson,P J Sadler. (1984-03-01) Use of high-resolution proton nuclear magnetic resonance spectroscopy for rapid multi-component analysis of urine.. Clinical chemistry, 30 ((3)): (426-432). [PMID:6321058]
7. F J Ballard,F M Tomas. (1983-09-01) 3-Methylhistidine as a measure of skeletal muscle protein breakdown in human subjects: the case for its continued use.. Clinical science (London, England : 1979), 65 ((3)): (209-215). [PMID:6872455]
8. G L Dohm,R T Williams,G J Kasperek,A M van Rij. (1982-01-01) Increased excretion of urea and N tau -methylhistidine by rats and humans after a bout of exercise.. Journal of applied physiology: respiratory, environmental and exercise physiology, 52 ((1)): (27-33). [PMID:7061274]
9. H M Liebich,H J Buelow,R Kallmayer. (1982-04-30) Quantification of endogenous aliphatic alcohols in serum and urine.. Journal of chromatography, 239 (343-349). [PMID:7096503]
10. D S Gill,V A Fonseca,M A Barradas,R Balliod,J F Moorhead,P Dandona. (1991-03-01) Plasma histamine in patients with chronic renal failure and nephrotic syndrome.. Journal of clinical pathology, 44 ((3)): (243-245). [PMID:2013627]
11. A Avogaro,D M Bier. (1989-11-01) Contribution of 3-hydroxyisobutyrate to the measurement of 3-hydroxybutyrate in human plasma: comparison of enzymatic and gas-liquid chromatography-mass spectrometry assays in normal and in diabetic subjects.. Journal of lipid research, 30 ((11)): (1811-1817). [PMID:2614280]
12. A Q Zhang,S C Mitchell,R L Smith. (1995-01-16) Dimethylamine in human urine.. Clinica chimica acta; international journal of clinical chemistry, 233 ((1-2)): (81-88). [PMID:7758205]
13. A V Greco,G Mingrone,E Capristo,G Benedetti,A De Gaetano,G Gasbarrini. (1998-05-20) The metabolic effect of dodecanedioic acid infusion in non-insulin-dependent diabetic patients.. Nutrition (Burbank, Los Angeles County, Calif.), 14 ((4)): (351-357). [PMID:9591306]
14. F Kvasnicka. (1999-05-18) Isotachophoretic determination of 3-methylhistidine.. Journal of chromatography. A, 838 ((1-2)): (191-195). [PMID:10327638]
15. R A Burke,J B Moberly,H Patel,T R Shockley,L Martis. (2000-01-29) Maltose and isomaltose in uremic plasma following icodextrin administration.. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis, 14 (120-123). [PMID:10649708]
16. D S Raj,M Ouwendyk,R Francoeur,A Pierratos. (2000-06-06) Plasma amino acid profile on nocturnal hemodialysis.. Blood purification, 18 ((2)): (97-102). [PMID:10838467]
17. T Myint,G E Fraser,K D Lindsted,S F Knutsen,R W Hubbard,H W Bennett. (2000-10-29) Urinary 1-methylhistidine is a marker of meat consumption in Black and in White California Seventh-day Adventists.. American journal of epidemiology, 152 ((8)): (752-755). [PMID:11052553]
18. D O McGregor,W J Dellow,M Lever,P M George,R A Robson,S T Chambers. (2001-05-31) Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations.. Kidney international, 59 ((6)): (2267-2272). [PMID:11380830]
19. Takahiro Kawasaki,Hiroshi Akanuma,Toshikazu Yamanouchi. (2002-01-30) Increased fructose concentrations in blood and urine in patients with diabetes.. Diabetes care, 25 ((2)): (353-357). [PMID:11815509]
20. Keitaro Yokoyama,Masamich Tajima,Hiraku Yoshida,Masaaki Nakayama,Goro Tokutome,Hiroshi Sakagami,Tatsuo Hosoya. (2002-05-29) Plasma pteridine concentrations in patients with chronic renal failure.. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 17 ((6)): (1032-1036). [PMID:12032193]
21. G Blomqvist,M Alvarsson,V Grill,G Von Heijne,M Ingvar,J O Thorell,S Stone-Elander,L Widén,K Ekberg. (2002-06-18) Effect of acute hyperketonemia on the cerebral uptake of ketone bodies in nondiabetic subjects and IDDM patients.. American journal of physiology. Endocrinology and metabolism, 283 ((1)): (E20-E28). [PMID:12067838]
22. Anna Walter,Ulrike Korth,Michael Hilgert,Joachim Hartmann,Oksana Weichel,Marion Hilgert,Klaus Fassbender,Andrea Schmitt,Jochen Klein. (2004-10-07) Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients.. Neurobiology of aging, 25 ((10)): (1299-1303). [PMID:15465626]
23. Petr Tůma,Eva Samcová,Pavla Balínová. (2005-05-19) Determination of 3-methylhistidine and 1-methylhistidine in untreated urine samples by capillary electrophoresis.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 821 ((1)): (53-59). [PMID:15899597]
24. Esther Vice,Jonathan D Privette,Robert C Hickner,Hisham A Barakat. (2005-10-29) Ketone body metabolism in lean and obese women.. Metabolism: clinical and experimental, 54 ((11)): (1542-1545). [PMID:16253646]
25. Marcus A Bain,Randall Faull,Gianfranco Fornasini,Robert W Milne,Allan M Evans. (2006-01-13) Accumulation of trimethylamine and trimethylamine-N-oxide in end-stage renal disease patients undergoing haemodialysis.. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 21 ((5)): (1300-1304). [PMID:16401621]
26. Shinichiro Mine,Yosuke Okada,Chie Kawahara,Takahiro Tabata,Yoshiya Tanaka. (2006-09-13) Serum hyaluronan concentration as a marker of angiopathy in patients with diabetes mellitus.. Endocrine journal, 53 ((6)): (761-766). [PMID:16966827]
27. Janez Stupar,Matjaz Vrtovec,Franci Dolinsek. (2006-12-13) Longitudinal hair chromium profiles of elderly subjects with normal glucose tolerance and type 2 diabetes mellitus.. Metabolism: clinical and experimental, 56 ((1)): (94-104). [PMID:17161231]
28. M J Serlie,A J Meijer,J E Groener,M Duran,E Endert,E Fliers,J M Aerts,H P Sauerwein. (2007-02-01) Short-term manipulation of plasma free fatty acids does not change skeletal muscle concentrations of ceramide and glucosylceramide in lean and overweight subjects.. The Journal of clinical endocrinology and metabolism, 92 ((4)): (1524-1529). [PMID:17264178]
29. Thanh M Nguyen,Luisa M Rodriguez,Kimberly J Mason,Rubina A Heptulla. (2007-07-31) Serum 1,5-anhydroglucitol (Glycomark) levels in children with and without type 1 diabetes mellitus.. Pediatric diabetes, 8 ((4)): (214-219). [PMID:17659063]
30. Jaime Guevara-Aguirre,Marco Guevara-Aguirre,Jeannette Saavedra,Gerald Bernstein,Arlan L Rosenbloom. (2007-08-21) Comparison of oral insulin spray and subcutaneous regular insulin at mealtime in type 1 diabetes.. Diabetes technology & therapeutics, 9 ((4)): (372-376). [PMID:17705693]
31. M Y Khuhawar,L A Zardari,A J Laghari. (2008-09-02) Capillary gas chromatographic determination of methylglyoxal from serum of diabetic patients by precolumn derivatization with 1,2-diamonopropane.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 873 ((1)): (15-19). [PMID:18760976]
32. Carsten Henneges,Dino Bullinger,Richard Fux,Natascha Friese,Harald Seeger,Hans Neubauer,Stefan Laufer,Christoph H Gleiter,Matthias Schwab,Andreas Zell,Bernd Kammerer. (2009-04-07) Prediction of breast cancer by profiling of urinary RNA metabolites using Support Vector Machine-based feature selection.. BMC cancer, 9 (104-104). [PMID:19344524]
33. Wolfram Gronwald,Matthias S Klein,Hannelore Kaspar,Stephan R Fagerer,Nadine Nürnberger,Katja Dettmer,Thomas Bertsch,Peter J Oefner. (2009-06-25) Urinary metabolite quantification employing 2D NMR spectroscopy.. Analytical chemistry, 80 ((23)): (9288-9297). [PMID:19551947]
34. Lei Zhou,Na Yan,Huige Zhang,Ximin Zhou,Qiaosheng Pu,Zhide Hu. (2010-08-06) Microwave-accelerated derivatization for capillary electrophoresis with laser-induced fluorescence detection: a case study for determination of histidine, 1- and 3-methylhistidine in human urine.. Talanta, 82 ((1)): (72-77). [PMID:20685438]
35. Wolfram Gronwald,Matthias S Klein,Raoul Zeltner,Bernd-Detlef Schulze,Stephan W Reinhold,Markus Deutschmann,Ann-Kathrin Immervoll,Carsten A Böger,Bernhard Banas,Kai-Uwe Eckardt,Peter J Oefner. (2011-03-11) Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine.. Kidney international, 79 ((11)): (1244-1253). [PMID:21389975]
36. Hongyun Wang,Pei Hu,Ji Jiang. (2011-09-29) Measurement of 1- and 3-methylhistidine in human urine by ultra performance liquid chromatography-tandem mass spectrometry.. Clinica chimica acta; international journal of clinical chemistry, 413 ((1-2)): (131-138). [PMID:21945731]
37. Xiaojuan Wang,Guolin Wu,Tao He,Yong Wang,Yinong Wang,Yunge Fan,Hui Gao,Jianbiao Ma. (2011-12-27) Novel pH-sensitive zwitterionic poly(amino acid) derivatives for drug delivery.. Journal of controlled release : official journal of the Controlled Release Society, 152 Suppl 1 (e93-e94). [PMID:22195952]
38. M Houweling,S G A van der Drift,R Jorritsma,A G M Tielens. (2012-05-23) Technical note: quantification of plasma 1- and 3-methylhistidine in dairy cows by high-performance liquid chromatography-tandem mass spectrometry.. Journal of dairy science, 95 ((6)): (3125-3130). [PMID:22612948]
39. Naoko Arashida,Rumi Nishimoto,Masashi Harada,Kazutaka Shimbo,Naoyuki Yamada. (2017-01-14) Highly sensitive quantification for human plasma-targeted metabolomics using an amine derivatization reagent.. Analytica chimica acta, 954 (77-87). [PMID:28081817]
40. Nadezda V Khodorova,Douglas N Rutledge,Marion Oberli,David Mathiron,Paulo Marcelo,Robert Benamouzig,Daniel Tomé,Claire Gaudichon,Serge Pilard. (2018-02-23) Urinary Metabolomics Profiles Associated to Bovine Meat Ingestion in Humans.. Molecular nutrition & food research, 63 ((1)): (e1700834-e1700834). [PMID:29468821]
41. Artur Gornischeff,Anneli Kruve,Riin Rebane. (2020-04-12) Characterization of wines with liquid chromatography electrospray ionization mass spectrometry: Quantification of amino acids via ionization efficiency values.. Journal of chromatography. A, 1620 (461012-461012). [PMID:32276856]
42. Dawei Yang,Xiaofang Yang,Yang Li,Peige Zhao,Rao Fu,Tianying Ren,Ping Hu,Yaping Wu,Hongjun Yang,Na Guo. (2020-06-20) Clinical significance of circulating tumor cells and metabolic signatures in lung cancer after surgical removal.. Journal of translational medicine, 18 ((1)): (243-243). [PMID:32552826]
43. J Sjölin,H Stjernström,G Arturson,E Andersson,G Friman,J Larsson. (1989-12-01) Exchange of 3-methylhistidine in the splanchnic region in human infection.. The American journal of clinical nutrition, 50 ((6)): (1407-1414). [PMID:2596430]
44. J Sjölin,H Stjernström,S Henneberg,E Andersson,J Mårtensson,G Friman,J Larsson. (1989-01-01) Splanchnic and peripheral release of 3-methylhistidine in relation to its urinary excretion in human infection.. Metabolism: clinical and experimental, 38 ((1)): (23-29). [PMID:2909828]
45. V A Rogoskin,A I Krylov,N S Khlebnikova. (1987-12-25) Gas chromatographic determination of 1- and 3-methylhistidine in biological fluids.. Journal of chromatography, 423 (33-40). [PMID:3443668]
46. J Sjölin,G Hjort,G Friman,L Hambraeus. (1987-12-01) Urinary excretion of 1-methylhistidine: a qualitative indicator of exogenous 3-methylhistidine and intake of meats from various sources.. Metabolism: clinical and experimental, 36 ((12)): (1175-1184). [PMID:3683186]
47. M M Jaweed,T N Ferraro,F R Alleva,T Balazs,C P Bianchi,T A Hare. (1986-09-01) Methylhistidine changes in tibialis anterior muscles of 6-mercaptopurine-treated rats.. Toxicology and industrial health, 2 ((2)): (69-77). [PMID:3787652]
48. K Giesecke,C Klingstedt,O Ljungqvist,L Hagenfeldt. (1994-06-01) The modifying influence of anaesthesia on postoperative protein catabolism.. British journal of anaesthesia, 72 ((6)): (697-699). [PMID:8024920]
49. P C Colombani,E Kovacs,P Frey-Rindova,W Frey,W Langhans,M Arnold,C Wenk. (1999-06-11) Metabolic effects of a protein-supplemented carbohydrate drink in marathon runners.. International journal of sport nutrition, 9 ((2)): (181-201). [PMID:10362454]
50. D H COCKS,P O DENNIS,T H NE. (1964-04-11) ISOLATION OF 3-METHYL HISTIDINE FROM WHALEMEAT EXTRACT AND THE PREPARATION OF SOME DERIVATIVES.. Nature, 202 (184-185). [PMID:14156296]
51. Jinyou Zhuang,Jennifer H Amoroso,Ryan Kinloch,John H Dawson,Michael J Baldwin,Brian R Gibney. (2004-12-21) Design of a five-coordinate heme protein maquette: a spectroscopic model of deoxymyoglobin.. Inorganic chemistry, 43 ((26)): (8218-8220). [PMID:15606161]
52. Angelo Zinellu,Salvatore Sotgia,Elisabetta Pisanu,Bastianina Scanu,Manuela Sanna,Luca Deiana,Ciriaco Carru. (2010-10-05) Quantification of histidine, 1-methylhistidine and 3-methylhistidine in plasma and urine by capillary electrophoresis UV-detection.. Journal of separation science, 33 ((23-24)): (3781-3785). [PMID:20886517]
53. Lili Zhang, Wen Duan, Yan Huang, Yuyu Zhang, Baoguo Sun, Dandan Pu, Yizhuang Tang, Chao Liu. (2020) Sensory taste properties of chicken (Hy-Line brown) soup as prepared with five different parts of the chicken. INTERNATIONAL JOURNAL OF FOOD PROPERTIES, [10.1080/10942912.2020.1828455]
54. Lu Wang, Limei Xiao, Shoujing Zheng, Jie Pang, Jiebo Chen. (2024) Characterization and assessment of free amino acids in different varieties of sugarcane. INDUSTRIAL CROPS AND PRODUCTS, 212 (118306). [10.1016/j.indcrop.2024.118306]

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

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稀释计算器

计算配制储备溶液所需的稀释度。

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复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

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