| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M104151-250mg |
250mg |
现货  |
|
| 别名 | 甲基萘醌,维生素K3 |
|---|---|
| 英文别名 | Juva-K | Kareon | MENADIONE [MART.] | 2-Methyl-1,4-naftochinon | Menadione (Vitamin K3) 10 microg/mL in Acetonitrile | Methyl-1,4-naphthoquinone | Koaxin | MLS000069420 | Kaynone | Menaquinone O | Menadione (USP:BAN) | 2-methyl-1,4-naphthoquinone, 5 | Kap |
| 规格或纯度 | 分析标准品 |
| 英文名称 | Menadione |
| 生化机理 | 维生素K能够抑制蛋白酪氨酸磷酸酶并诱导DNA链断裂。能够预防厄洛替尼诱导的细胞周期停滞。产生ROS°。体内具有活性 |
| 储存温度 | 避光,干燥 |
| 运输条件 | 常规运输 |
| 备注 | 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| 产品介绍 |
溶于乙醇(1 G/60 ML) 、苯(1 G/10 ML)、氯仿、四氯化碳和植物油(1 G/50 ML)等，不溶于水。遇光或铁质分解变质，能随水蒸气挥发。 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 200-372-6 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | 2-methylnaphthalene-1,4-dione |
| INCHI | 1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3 |
| InChi Key | MJVAVZPDRWSRRC-UHFFFAOYSA-N |
| Smiles | CC1=CC(=O)C2=CC=CC=C2C1=O |
| Isomeric SMILES | CC1=CC(=O)C2=CC=CC=C2C1=O |
| UN Number | 1325 |
| 分子量 | 172.18 |
| Beilstein号 | 1908453 |
| Reaxy-Rn | 1908453 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1908453&ln= |
| 密度 | 1.225 |
|---|---|
| 敏感性 | 对光敏感 |
| 熔点 | 105-108°C |
| 分子量 | 172.180 g/mol |
| XLogP3 | 2.200 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 2 |
| 可旋转键计数Rotatable Bond Count | 0 |
| 精确质量Exact Mass | 172.052 Da |
| 单同位素质量Monoisotopic Mass | 172.052 Da |
| 拓扑极表面积Topological Polar Surface Area | 34.100 Ų |
| 重原子数Heavy Atom Count | 13 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 288.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H302: 吞食有害 H315: 引起皮肤刺激 H317: 可能引起皮肤过敏反应 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H341: 怀疑引起遗传缺陷 H361: 怀疑破坏生育力或未出生的孩子 H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P272: 被污染的工作服不允许离开工作场所 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P281: 根据需要使用个人防护设备。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P391: 收集溢出物 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P203: 使用前，获取、阅读并遵守所有安全说明。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P318: 如果暴露或担心，请就医。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | QL9100000 |
| Merck Index | 5831 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Faceshields,Gloves |
| 1. Lei Jiang, Lin Yuan, Shan Gao, Yingying Xiang, Fei Song, Wensi Ma, Jing Wan, Xiuling Ji, Yujiao Tu. (2023) Facile hydrothermal synthesis of N-doped fluorescent carbon dots for selective detection of insecticide parathion. Analytical Methods, 15 (19): (2376-2381). [PMID:37132329] [10.1039/D3AY00124E] |
| 2. Huijun Wang, Jianxun Li, Chaoyang Zhang, Baoshan Sun, Yawen Zhou, Yanyan Zhou, Haiyu Zhao. (2023) Metabolomics approach, in vitro and in vivo antioxidant activity assay provide insights into impact of multiple variations on the vine tea (Ampelopsis grossedentata). LWT-FOOD SCIENCE AND TECHNOLOGY, 177 (114578). [10.1016/j.lwt.2023.114578] |
| 3. Chen Xu, Rijin Song, Pei Lu, Jianchun Chen, Yongqiang Zhou, Gang Shen, Minjun Jiang, Wei Zhang. (2023) A pH-Responsive Charge-Reversal Drug Delivery System with Tumor-Specific Drug Release and ROS Generation for Cancer Therapy. International Journal of Nanomedicine, [PMID:32021165] [10.2147/IJN.S230237] |
| 4. Wang Hongkang, Ji Zhe, Feng Yanru, Yan Tianhua, Cao Yongbing, Lu Hui, Jiang Yuanying. (2022) Myriocin enhances the antifungal activity of fluconazole by blocking the membrane localization of the efflux pump Cdr1. Frontiers in Pharmacology, 13 [PMID:36618949] [10.3389/fphar.2022.1101553] |
| 5. Yanjing Ou, Mingdong Yan, Guanglin Gao, Wenjie Wang, Qiaoqiao Lu, Jiang Chen. (2022) Cinnamaldehyde protects against ligature-induced periodontitis through the inhibition of microbial accumulation and inflammatory responses of host immune cells. Food & Function, 13 (15): (8091-8106). [PMID:35792680] [10.1039/D2FO00963C] |
| 6. Jiahong Guo, Xiaoyu Ma, Fernando Bouffard, Sophia Yi Zhang. (2022) A Novel multi-fruit acids formula design on molecular basis for skin brightening via a system biology approach. Journal of Cosmetic Dermatology, 21 (11): (6145-6155). [PMID:35713107] [10.1111/jocd.15163] |
| 7. Guoliang Ma, Zhiming Zheng, Han Wang, Li Wang, Genhai Zhao, Hengfang Tang, Xiumin Ding, Peng Wang. (2022) Preparation of Cellulose-Based Flocculant and Its Application in the Enrichment of Vitamin K2 in Fermentation Supernatant. Polymers, 14 (12): (2410). [PMID:35745984] [10.3390/polym14122410] |
| 8. Fang Zhang, Fuwei Pan, Hairong Wang. (2022) Nisoldipine in Several Aqueous and Non-Aqueous Cosolvent Solutions: Solubility Modeling and Preferential Solvation Research. JOURNAL OF CHEMICAL AND ENGINEERING DATA, 67 (2): (510–520). [10.1021/acs.jced.1c00729] |
| 9. Kai Zhang, Zhonghui Zhuo, Guorong Fan, Zongde Wang, Shangxing Chen, Lulu Xu, Yangping Wen, Peng Wang. (2021) Nano-ZnS decorated hierarchically porous carbon electrocatalyst with multiple enzyme-like activities as a nanozyme sensing platform for simultaneous detection of dopamine, uric acid, guanine, and adenine. Nanoscale, 13 (47): (20078-20090). [PMID:34846060] [10.1039/D1NR06017A] |
| 10. Bingfeng Liang, Dangxia Zhou. (2021) ROS-Activated homodimeric podophyllotoxin nanomedicine with self-accelerating drug release for efficient cancer eradication. DRUG DELIVERY, 28 (1): (2361-2372). [PMID:34747277] [10.1080/10717544.2021.1995076] |
| 11. Bailiang Wang, Liyang Zhou, Yishun Guo, Hanwen Guo, Yiming Zhong, Xiaomin Huang, Yifan Ge, Qingying Wang, Xiaoying Chu, Yingying Jin, Kaiyue Lan, Mei Yang, Jia Qu. (2022) Cyanobacteria-based self-oxygenated photodynamic therapy for anaerobic infection treatment and tissue repair. Bioactive Materials, 12 (314). [PMID:35128179] [10.1016/j.bioactmat.2021.10.032] |
| 12. Zhao Chenyu, Wang Guangshu, Sun Mengtao, Cai Zewei, Yin Zichu, Cai Yurong. (2021) Bacterial Cellulose Immobilized S. cerevisiae as Microbial Sensor for Rapid BOD Detection. FIBERS AND POLYMERS, 22 (5): (1208-1217). [10.1007/s12221-021-0650-5] |
| 13. Xiao Tu, Chenxi Duan, Siwei Wu, Shengli Fu, Jianmin Ye. (2021) Identification of plumbagin as an effective chemotherapeutic agent for treatment of Gyrodactylus infections. AQUACULTURE, 535 (736372). [10.1016/j.aquaculture.2021.736372] |
| 14. Zhang Zhicheng, Ding Yawen, Li Jinbiao, Wang Li, Xin Xiaoyan, Yan Jing, Wu Jinhui, Yuan Ahu, Hu Yiqiao. (2021) Versatile iron-vitamin K3 derivative-based nanoscale coordination polymer augments tumor ferroptotic therapy. Nano Research, 14 (7): (2398-2409). [10.1007/s12274-020-3241-7] |
| 15. Xiuling Ji, Suping Wang, Yiyong Luo, Xiaotian Yuan, Yunlin Wei, Qi Zhang, Kunhao Qin, Yujiao Tu. (2021) Green synthesis of weissella-derived fluorescence carbon dots for microbial staining, cell imaging and dual sensing of vitamin B12 and hexavalent chromium. DYES AND PIGMENTS, 184 (108818). [10.1016/j.dyepig.2020.108818] |
| 16. Yi Yu, Fanfan Li, Shanghai Long, Li Xu, Guoji Liu. (2020) Solubility, thermodynamic properties, HSP, and molecular interactions of vitamin K3 in pure solvents. JOURNAL OF MOLECULAR LIQUIDS, 317 (113945). [10.1016/j.molliq.2020.113945] |
| 17. Wei Qi, Mengjie Li, Long Zhao. (2020) Effect of radiation on interfacial properties and phase behavior of ionic liquid-based microemulsions. RADIATION PHYSICS AND CHEMISTRY, 168 (108596). [10.1016/j.radphyschem.2019.108596] |
| 18. Lin Yanke, Wang Shuai, Zhou Ziyue, Guo Lianxia, Yu Fangjun, Wu Baojian. (2019) Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice. Communications Biology, 2 (1): (1-11). [PMID:31633069] [10.1038/s42003-019-0607-z] |
| 19. Yi Yu, Xiaoqiang Gao, Zhouxuan Zang, Li Xu, Guoji Liu. (2019) Solid-liquid equilibrium for the ternary 2-naphthaldehyde + 2-methyl-1,4-naphthoquinone + ethanol system: Determination, correlation and molecular simulation. JOURNAL OF MOLECULAR LIQUIDS, 284 (131). [10.1016/j.molliq.2019.03.104] |
| 20. Jia Wang, Guangzhi Zeng, Xiaobing Huang, Zhe Wang, Ninghua Tan. (2017) 1,4-Naphthoquinone Triggers Nematode Lethality by Inducing Oxidative Stress and Activating Insulin/IGF Signaling Pathway in Caenorhabditis elegans. MOLECULES, 22 (5): (798). [PMID:28505088] [10.3390/molecules22050798] |
| 21. Fang Zhang, Long Wang, Yaocun Tang, Xiaoqiang Gao, Li Xu, Guoji Liu. (2016) Measurement and correlation of ternary solid–liquid equilibrium of 2-methyl-1,4-naphthoquinone + phthalic anhydride + acetone system. FLUID PHASE EQUILIBRIA, 409 (98). [10.1016/j.fluid.2015.09.019] |
| 22. Beiying Yang, Xiu Zeng, Yu Ge, Weining Liu, Wenxue Hao, Chunyingzi Long, Linkang Wang, Qianyue Wu, Yangping Wen, Jinhua Zhang. (2024) A new method for rapid, portable, low-cost detection of Clostridium perfringens β2 toxin in animal fecal using smartphone-based electrochemical immunosensor. MICROCHEMICAL JOURNAL, 198 (110138). [10.1016/j.microc.2024.110138] |
| 23. Jia-Yi Weng, Jia-Yu Yang, Ishimwe Steven Papy, Bu-Tao Yu, Yu-Feng Ke, Bing-Yu Bai, Mitchell N. Muskat, Qian Wu, Xiang-Rong Cheng. (2024) Cinnamaldehyde alleviates hepatic steatosis correlating with its electrophilic capability. Food Bioscience, 59 (104142). [10.1016/j.fbio.2024.104142] |
| 24. Hai-Long Yu, Xiao-Long Liang, Zhen-Yang Ge, Zhi Zhang, Yao Ruan, Hao Tang, Qing-Ye Zhang. (2024) Metabolic Flux Analysis of Xanthomonas oryzae Treated with Bismerthiazol Revealed Glutathione Oxidoreductase in Glutathione Metabolism Serves as an Effective Target. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25 (22): (12236). [PMID:39596301] [10.3390/ijms252212236] |
| 25. Zhongcan Peng, Wenfeng Li, Yingchao Wang, Longping Zhu, Depo Yang, Guomin Zhao, Peng Zhong, Zhimin Zhao. (2025) The physicochemical properties of low molecular weight ‘Chachi’ (Citrus reticulata ‘Chachi’) pectins prepared by different modification methods and their modulation effects on the human gut microbiota. FOOD HYDROCOLLOIDS, 166 (111350). [10.1016/j.foodhyd.2025.111350] |
首页
400-620-6333
25篇引用文献 
I2406515