| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| L647054-1mg |
1mg |
期货  |
|
| 英文别名 | (+)-L-873724 | MS-28951 | 29250PP3ON | AKOS040742150 | (2S)-N-(cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfon | L873724 | L-873724 | UNII-29250PP3ON | GTPL7860 | HY-50887 | Pentanamide, N-(cyanomethyl)-4-methyl-2-(((1S)-2,2,2-trifluor |
|---|---|
| 规格或纯度 | ≥98% |
| 英文名称 | L-873724 |
| 生化机理 | L-873724 是一种强效、口服生物可利用性、选择性和还原性的 cathepsin K 抑制剂，对 cathepsin K、chepsin S、chepsin L 和 cathepsin B 的 IC 50 s 分别为 0.2、178、264 和 5239 nM。此外，L-873724 还显示出对胰蛋白酶 K、胰蛋白酶 S、胰蛋白酶 L 和胰蛋白酶 B |
| 储存温度 | 2-8°C储存,避光,干燥 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
L-873724 is a potent, orally bioavailable, selective and reversible non-basic cathepsin K inhibitor , with IC 50 s of 0.2, 178, 264, and 5239 nM for cathepsin K , cathepsin S , cathepsin L , cathepsin B , respectively L-873724 also exhibits an IC 50 of 0.5 nM for rabbit cathepsin K . L-873724 inhibits bone resorption . In Vitro L-873724 (Compound 22) is a potent and selective non-basic cathepsin K inhibitor, with IC 50 s of 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively. L-873724 also shows IC 50 s of 95, 1221 and 4807 nM for Ramos cathepsin S, Hep G2 cathepsin L, Hep G2 cathepsin B. L-873724 exhibits an IC 50 of 0.5 nM for rabbit cathepsin K. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo L-873724 is orally bioavailable, non-lysosomotropic, and efficacious in the rhesus monkey bone resorption model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 0.2 nM (Cathepsin K), 178 nM (Cathepsin S), 264 nM (Cathepsin B), 5239 nM (Cathepsin B), 0.5 nM (Rabbit cathepsin K) |
| 纯度 | ≥98% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (2S)-N-(cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide |
| INCHI | 1S/C23H26F3N3O3S/c1-15(2)14-20(22(30)28-13-12-27)29-21(23(24,25)26)18-6-4-16(5-7-18)17-8-10-19(11-9-17)33(3,31)32/h4-11,15,20-21,29H,13-14H2,1-3H3,(H,28,30)/t20-,21-/m0/s1 |
| InChi Key | VYFDSJLOCIGIKP-SFTDATJTSA-N |
| Smiles | CC(C)CC(C(=O)NCC#N)NC(C1=CC=C(C=C1)C2=CC=C(C=C2)S(=O)(=O)C)C(F)(F)F |
| Isomeric SMILES | CC(C)C[C@@H](C(=O)NCC#N)N[C@@H](C1=CC=C(C=C1)C2=CC=C(C=C2)S(=O)(=O)C)C(F)(F)F |
| 关联CAS | 603139-12-4 |
| PubChem CID | 9913088 |
| MeSH Entry Terms | L-873724 |
| 分子量 | 481.53 |
| 溶解性 | DMSO : 100 mg/mL (207.67 mM; Need ultrasonic) |
|---|---|
| 分子量 | 481.500 g/mol |
| XLogP3 | 4.200 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 8 |
| 可旋转键计数Rotatable Bond Count | 9 |
| 精确质量Exact Mass | 481.165 Da |
| 单同位素质量Monoisotopic Mass | 481.165 Da |
| 拓扑极表面积Topological Polar Surface Area | 107.000 Ų |
| 重原子数Heavy Atom Count | 33 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 785.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 2 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
首页
400-620-6333
