| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| L646464-5mg |
5mg |
期货  |
|
| 别名 | LIMK1抑制剂BMS-4 |
|---|---|
| 规格或纯度 | ≥99% |
| 英文名称 | LIMK1 inhibitor BMS-4 |
| 生化机理 | LIMK1 抑制剂 BMS-4 是一种 LIMK 激酶（LIMK）抑制剂，靶向 LIMK1/2。LIMK1 抑制剂 BMS-4 可抑制 LIMK 底物 cofilin 的磷酸化。然而，LIMK1 抑制剂 BMS-4 对 A549 细胞无细胞毒性。 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 产品介绍 |
LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells. In Vitro LIMK1 inhibitor BMS-4 (compound 4) (0.014-10 μM; 24 h) inhibits LIMKs in vitro without affecting A549 cell survival or proliferation. LIMK1 inhibitor BMS-4 (0.014-1 μM; 2 h) inhibits phosphorylation of the LIMK substrate cofilin in A549 human lung cancer cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid |
| 纯度 | ≥99% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 1-ethyl-3-[5-[6-(4-methoxy-2,6-dimethylphenyl)-2-pyrazin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-yl]urea |
| INCHI | 1S/C23H23N7O2S/c1-5-25-22(31)30-23-27-12-19(33-23)16-10-17(20-13(2)8-15(32-4)9-14(20)3)29-21(28-16)18-11-24-6-7-26-18/h6-12H,5H2,1-4H3,(H2,25,27,30,31) |
| InChi Key | WUCYRTXFXRZKSV-UHFFFAOYSA-N |
| Smiles | CCNC(=O)NC1=NC=C(S1)C2=CC(=NC(=N2)C3=NC=CN=C3)C4=C(C=C(C=C4C)OC)C |
| Isomeric SMILES | CCNC(=O)NC1=NC=C(S1)C2=CC(=NC(=N2)C3=NC=CN=C3)C4=C(C=C(C=C4C)OC)C |
| PubChem CID | 46192505 |
| 分子量 | 461.54 |
| 分子量 | 461.500 g/mol |
|---|---|
| XLogP3 | 2.600 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 8 |
| 可旋转键计数Rotatable Bond Count | 6 |
| 精确质量Exact Mass | 461.163 Da |
| 单同位素质量Monoisotopic Mass | 461.163 Da |
| 拓扑极表面积Topological Polar Surface Area | 143.000 Ų |
| 重原子数Heavy Atom Count | 33 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 632.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
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