| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| L611558-5mg |
5mg |
期货  |
| |
| L611558-25mg |
25mg |
期货 |
|
| 别名 | LLL-12 |
|---|---|
| 英文别名 | 9,10-Dihydro-5-hydroxy-9,10-dioxo-1-anthracenesulfonamide | NCGC00345811-01 | 5-hydroxy-9,10-dioxoanthracene-1-sulfonamide | BDBM420304 | HY-19536 | LLL12 | LLL-12 | SCHEMBL12310760 | 1260247-42-4 | GTPL12267 | 5-hydroxy-9,10-dioxo-9,10-dihydroanthracene- |
| 规格或纯度 | Moligand™ |
| 英文名称 | LLL12 |
| 作用类型 | 抑制剂 |
| 作用机制 | 信号转导和转录激活因子 3 抑制剂 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 5-hydroxy-9,10-dioxoanthracene-1-sulfonamide |
| INCHI | 1S/C14H9NO5S/c15-21(19,20)10-6-2-4-8-12(10)14(18)7-3-1-5-9(16)11(7)13(8)17/h1-6,16H,(H2,15,19,20) |
| InChi Key | CQBHSRLUQDYPBU-UHFFFAOYSA-N |
| Smiles | C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C(=CC=C3)S(=O)(=O)N |
| Isomeric SMILES | C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C(=CC=C3)S(=O)(=O)N |
| 关联CAS | 1260247-42-4 |
| PubChem CID | 46911017 |
| MeSH Entry Terms | 5-hydroxy-9,10-dioxo-anthracene-1-sulfonamide;LLL 12;LLL-12 |
| 分子量 | 303.290 g/mol |
|---|---|
| XLogP3 | 2.100 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 6 |
| 可旋转键计数Rotatable Bond Count | 1 |
| 精确质量Exact Mass | 303.02 Da |
| 单同位素质量Monoisotopic Mass | 303.02 Da |
| 拓扑极表面积Topological Polar Surface Area | 123.000 Ų |
| 重原子数Heavy Atom Count | 21 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 566.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 1. Lin L, Hutzen B, Li PK, Ball S, Zuo M, DeAngelis S, Foust E, Sobo M, Friedman L, Bhasin D et al.. (2010) A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.. Neoplasia, 12 (1): (39-50). [PMID:20072652] |
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