| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| L424357-1ml |
1ml |
期货  |
|
| 别名 | 全顺式-6,9,12-十八碳三烯酸 | 顺,顺,顺-6,9,12-十八碳三烯酸 |
|---|---|
| 英文别名 | 6,9,12-Octadecatrienoic acid, (6Z,9Z,12Z)- | Acide gamolenique [French] | cis,cis,cis-6,9,12-Octadecatrienoic acid | D58CCA4A-7FFA-4E8B-A758-EAA7D073B343 | gamma-linolenic-acid | z,z,z-octadeca-6,9,12-trienoic acid | (6Z,9Z,12Z)-6,9,12-Octadecatrienoic ac |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | γ-Linolenic acid |
| 生化机理 | 不饱和脂肪酸。推定的抗癌剂。亚油酸衍生物。诱导产生ROS。使NFκB失活。也可能通过过氧化物酶体增殖物激活的受体（PPAR）刺激其磷酸化和易位 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Usually used as an analytical standard in gas chromatography,and also used in nutritional studies regarding weight regain and as a possible tumor suppression agent. γ-linolenic acid is used in studies on the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids. Usually used as an analytical standard in gas chromatography,and also used in nutritional studies regarding weight regain and as a possible tumor suppression agent. γ-linolenic acid is used in studies on the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid |
| INCHI | 1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/b7-6-,10-9-,13-12- |
| InChi Key | VZCCETWTMQHEPK-QNEBEIHSSA-N |
| Smiles | CCCCCC=CCC=CCC=CCCCCC(=O)O |
| Isomeric SMILES | CCCCC/C=C\C/C=C\C/C=C\CCCCC(=O)O |
| 分子量 | 278.43 |
| Beilstein号 | 1712253 |
| Reaxy-Rn | 8151168 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8151168&ln= |
| 敏感性 | 对光、空气、热敏感 |
|---|---|
| 折光率 | 1.48 |
| 闪点(℉) | 230.0 °F |
| 闪点(℃) | 110°C |
| 分子量 | 278.400 g/mol |
| XLogP3 | 5.900 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 2 |
| 可旋转键计数Rotatable Bond Count | 13 |
| 精确质量Exact Mass | 278.225 Da |
| 单同位素质量Monoisotopic Mass | 278.225 Da |
| 拓扑极表面积Topological Polar Surface Area | 37.300 Ų |
| 重原子数Heavy Atom Count | 20 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 301.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 3 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 3 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| Merck Index | 5507 |
| 个人防护装备 | Eyeshields,full-face respirator (US),Gloves,multi-purpose combination respirator cartridge (US),type ABEK (EN14387) respirator filter |
| 1. Hongshuai Lv, Weiping Jia, Li Yang, Peng Dong, Jiaojiao Liu, Si Wang, Xiaohai Li, Jinghua Hu, Ling Zhao, Yikang Shi. (2023) Influence of unsaturated fatty acids on the antitumor activity of polymeric conjugates grafted with cabazitaxel against prostate cancer. BIOMEDICINE & PHARMACOTHERAPY, 169 (115902). [PMID:37989031] [10.1016/j.biopha.2023.115902] |
| 2. Lei He, Qian Hu, Liyang Wei, Xuliyang Ge, Ning Yu, Ying Chen. (2023) Unravelling dynamic changes in non-volatile and volatile metabolites of pulses during soaking: An integrated metabolomics approach. FOOD CHEMISTRY, 422 (136231). [PMID:37141754] [10.1016/j.foodchem.2023.136231] |
| 3. Ge Tang, Kuaqian Deng, Panyang Li, Jiali Huang, Fanglin Dao, Hao Jiang, Jing Wang, Jianfang Jiang. (2023) One-pot method of recyclable lipase-nanocatalyst based on chitosan magnetic nanomaterial for ethyl levulinate synthesis. COMPOSITES SCIENCE AND TECHNOLOGY, 236 (110002). [10.1016/j.compscitech.2023.110002] |
| 4. Yang-Yang Li, Xin-Xin Ma, Xin-Yan Song, Lin-Lin Ma, Yu-Ying Li, Xin Meng, Yu-Jie Chen, Ke-Xin Xu, Ali Akbar Moosavi-Movahedi, Bao-Lin Xiao, Jun Hong. (2023) Glucose Biosensor Based on Glucose Oxidase Immobilized on BSA Cross-Linked Nanocomposite Modified Glassy Carbon Electrode. SENSORS, 23 (6): (3209). [PMID:36991919] [10.3390/s23063209] |
| 5. Hongxu Zhou, Qing Jiang, Xin He, Xian Fu, Jun-Yan Liu. (2024) A complementary method with PFBBr-derivatization based on GC-EI-MS platform for the simultaneous quantitation of short-, medium- and long -chain fatty acids in murine plasma and feces samples. Analytical Methods, [PMID:38562090] [10.1039/D3AY02271D] |
| 6. Jiaxing Yang, Laiying Zhang, Xinlian He, Xupeng Gou, Zhiyong Zong, Youfu Luo. (2024) In vitro and in vivo enhancement effect of glabridin on the antibacterial activity of colistin, against multidrug resistant Escherichia coli strains. PHYTOMEDICINE, 130 (155732). [PMID:38776738] [10.1016/j.phymed.2024.155732] |
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