| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| L420721-1ml |
1ml |
现货  |
|
| 英文别名 | losartan | 114798-26-4 | DUP 89 | allisartan | Angizaar | Losartic | Hyzaar | Cozaar | Lozap | LOSARTAN POTASSIUM | CHEBI:6541 | DUP-89 | DTXSID7023227 | UNII-JMS50MPO89 | JMS50MPO89 | Losartan (INN) | NSC-758699 | HGP1405 | HGP-1405 | DuP-753 | (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphen |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Losartan |
| 生化机理 | Losartan is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan is used for treatment of hypertension. |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 拮抗剂 |
| 作用机制 | AT 1 受体拮抗剂 |
| 产品介绍 |
氯沙坦是一种有效的非肽类血管紧张素II受体（AT1）拮抗剂。该受体引发引起血管收缩的信号级联。该受体的拮抗作用通过阻断血管紧张素II的信号进而引起血管舒张。 Losartan is a potent, non-peptide antagonist of angiotensin II receptor, type 1 (AT1). This receptor initiates a signal cascade that causes vasoconstriction. Antagonism of this receptor in turn causes vasodilation by blocking the signal from angiotensin II. |
| EC号 | 601-329-8 |
|---|---|
| IIUPAC Name | [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol |
| INCHI | 1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28) |
| InChi Key | PSIFNNKUMBGKDQ-UHFFFAOYSA-N |
| Smiles | CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl |
| Isomeric SMILES | CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl |
| 关联CAS | 114798-26-4,124750-99-8 (mono-potassium salt) |
| NSC Number | 758699 |
| MeSH Entry Terms | 2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol;Cozaar;DuP 753;DuP-753;DuP753;Losartan;Losartan Monopotassium Salt;Losartan Potassium;MK 954;MK-954;MK954;Monopotassium Salt, Losartan;Potassium, Losartan;Salt, |
| 分子量 | 422.92 |
| Reaxy-Rn | 4828951 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4828951&ln= |
| 熔点 | 183.5-184.5° C |
|---|---|
| 分子量 | 422.900 g/mol |
| XLogP3 | 4.300 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 8 |
| 精确质量Exact Mass | 422.162 Da |
| 单同位素质量Monoisotopic Mass | 422.162 Da |
| 拓扑极表面积Topological Polar Surface Area | 92.500 Ų |
| 重原子数Heavy Atom Count | 30 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 520.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07, GHS08 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H315: 引起皮肤刺激 H317: 可能引起皮肤过敏反应 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H360: 可能损害生育力或未出生的孩子 H362: 可能对母乳喂养的孩子造成伤害 H413: 可能对水生生物造成长期的有害影响 |
| 预防措施声明 |
P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P263: 避免在怀孕期间/哺乳期间接触。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P272: 被污染的工作服不允许离开工作场所 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P203: 使用前，获取、阅读并遵守所有安全说明。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P318: 如果暴露或担心，请就医。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| 1. Qinglin Wang, Hao Yuan, Xinyue Pan, Yiling Yang, Xiaosong Ma, Yahui Guo. (2024) Synthesis of silver nanoclusters using a double-stranded DNA template and its application for captopril detection. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 126 (105825). [10.1016/j.jfca.2023.105825] |
| 2. Xinyang Li, Yang Luo, Zhengjie Huang, Yi Wang, Jian Wu, Shaobing Zhou. (2023) Multifunctional Liposomes Remodeling Tumor Immune Microenvironment for Tumor Chemoimmunotherapy. Small Methods, 7 (5): (2201327). [PMID:37075716] [10.1002/smtd.202201327] |
| 3. Yihui Huang, Jingwen Li, Yan Wang, Danyang Chen, Jianglong Huang, Wubin Dai, Pan Peng, Liang Guo, Yifeng Lei. (2023) Intradermal delivery of an angiotensin II receptor blocker using a personalized microneedle patch for treatment of hypertrophic scars. Biomaterials Science, 11 (2): (583-595). [PMID:36475528] [10.1039/D2BM01631A] |
| 4. Liqian Chen, Xinghong Zhou, Yijian Deng, Ying Yang, Xiaohu Chen, Qinghong Chen, Yanyan Liu, Xiuqiong Fu, Hiu Yee Kwan, Yanting You, Wen Jin, Xiaoshan Zhao. (2023) Zhenwu decoction ameliorates cardiac hypertrophy through activating sGC (soluble guanylate cyclase) - cGMP (cyclic guanosine monophosphate) - PKG (protein kinase G) pathway. JOURNAL OF ETHNOPHARMACOLOGY, 300 (115705). [PMID:36099983] [10.1016/j.jep.2022.115705] |
| 5. Sun Zhiping, He Lingli, Yang Qingqing, Zhang Haizhi, Xu Weiren, Qin Xinguang, Liu Gang, Hu Zhongze, Zhang Luyong, Liu Changxiao. (2022) Study on the Effect of Three CYP2C9 Variants on Drug–Drug Interaction Related to Six Drugs In Vitro by LC–MS/MS Method. CHROMATOGRAPHIA, 85 (3): (221-231). [10.1007/s10337-021-04126-8] |
| 6. Yuanyuan Chai, Yunxia Xu, Ziyin Xia, Xin Huang, Luyong Zhang, Zhenzhou Jiang. (2021) Study on the effects of Zhuanggu Guanjie Pill, a modern Chinese medicine formula, on the activities and mRNA expression of seven CYP isozymes in rats. JOURNAL OF ETHNOPHARMACOLOGY, 281 (114521). [PMID:34390794] [10.1016/j.jep.2021.114521] |
| 7. Zhuoqing Cheng, Honghong Zhan, Han Yuan, Nan Wang, Yi Lan, Weijian Qu, Xiaozhong Lan, Zhihua Liao, Guowei Wang, Min Chen. (2025) Boeravinone C ameliorates lipid accumulation and inflammation in diabetic kidney disease by activating PPARα signaling. JOURNAL OF ETHNOPHARMACOLOGY, (119398). [PMID:39880066] [10.1016/j.jep.2025.119398] |
| 8. Yanan Guo, Shuang Cao, Bin Geng, Juanjuan Ma, Bo Yao. (2025) Determination of sacubitril and seven sartan drugs in serum samples by online solid phase extraction-liquid chromatography-tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 254 (116580). [PMID:39603194] [10.1016/j.jpba.2024.116580] |
| 9. Haoyang Zou, Shuang Liao, Ruiqi Lu, Yong Pang, Junfeng Li, Jie Zhang. (2025) Geniposide regulates glucocorticoid receptor signaling to prevent lipid metabolism disorder in high-fat diet-fed zebrafish. Food Bioscience, 66 (106277). [10.1016/j.fbio.2025.106277] |
| 10. Bing Li, Shuanglong Mou, Chenrui Zhang, Tingting Zhu, Xingwei Hu, Mengsha Li. (2025) Ginsenoside Rh2 Ameliorates Myocardial Infarction by Regulating Cardiomyocyte Pyroptosis Based on Network Pharmacology, Molecular Docking, and Experimental Verification. AMERICAN JOURNAL OF CHINESE MEDICINE, 53 (2): (475-499). [PMID:40099395] [10.1142/S0192415X25500181] |
| 11. Irfan Ijaz, Aysha Bukhari, Ammara Nazir, Ezaz Gilani, Hina Zain, Attia Shaheen, Mohammed Rafi Shaik, Mujeeb Khan. (2025) Modification of bacterial cellulose by MoBTx MBene and 1,4-dithiothreitol for rapid and efficient adsorption of indomethacin and losartan potassium. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 304 (140745). [PMID:39922337] [10.1016/j.ijbiomac.2025.140745] |
首页
400-620-6333
11篇引用文献 
