| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| L409034-1ml |
1ml |
现货  |
|
| 别名 | 氯尼达明 (AF-1890) |
|---|---|
| 英文别名 | Diclondazolic Acid, DICA | 1-[(2,4-dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Lonidamine (AF-1890) |
| 生化机理 | 洛尼达明（AF 1890，Diclondazolic Acid，DICA）是一种口服小分子己糖激酶灭活剂。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 类似线粒体丙酮酸载体 1 的抑制剂；线粒体丙酮酸载体 2 的抑制剂 |
| 产品介绍 |
Information Lonidamine (AF-1890) Lonidamine (AF 1890, Diclondazolic Acid, DICA) is an orally administered small molecule hexokinase inactivator. Lonidamine reduces the oxygen consumption in both normal and neoplastic cells, while it increases the aerobic glycolysis of normal cells but inhibited that of tumor cells. Lonidamine induces the permeabilization of ANT proteoliposomes in a cell-free system, yet has no effect on protein-free liposomes. Lonidamine adds to synthetic planar lipid bilayers containing ANT, eliciting ANT channel activities with clearly distinct conductance levels. Lonidamine provokes a disruption of the mitochondrial transmembrane potential which precedes signs of nuclear apoptosis and cytolysis. Lonidamine causes the dissipation of the mitochondrial inner transmembrane potential and the release of apoptogenic factors capable of inducing nuclear apoptosis in vitro. Lonidamine (50 mg/mL) induces apoptosis in adriamycin and nitrosourea-resistant cells (MCF-7 ADR(r) human breast cancer cell line, and LB9 glioblastoma multiform cell line), as demonstrated by sub-G1 peaks in DNA content histograms, condensation of nuclear chromatin, and internucleosomal DNA fragmentation. Lonidamine has a stronger effect on glioblastoma cell proliferation and metabolism in vitro than did either agent used alone. In vivo Lonidamine (160 mg/kg) combined with Diazepam is significantly more effective in reducing glioblastoma tumor growth than either drug alone in mice, this tumor growth retardation is maintained as long as treatment is given. cell lines：T47D, ZR-75-1, BT474, HCC1954, MDA-MB-453, LNCaP, etc. Concentrations： Incubation Time： Powder Purity:≥97% |
| EC号 | 256-510-0 |
|---|---|
| Isomeric SMILES | C1=CC=C2C(=C1)C(=NN2CC3=C(C=C(C=C3)Cl)Cl)C(=O)O |
| 关联CAS | 50264-69-2 |
| NSC Number | 741419 |
| MeSH Entry Terms | 1-(2,4-dichlorobenzyl)indazole-3-carboxylic acid;AF 1890;diclondazolic acid;lonidamine |
| 分子量 | 321.16 |
| Reaxy-Rn | 894483 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=894483&ln= |
| 溶解性 | Solubility (25°C) In vitro |
|---|---|
| 熔点 | 210 °C |
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