| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| L115716-20mg |
20mg |
现货  |
|
| 别名 | 甘草醇 | 7,4′-二羟基黄酮 | 7-羟基-2-（4-羟基苯基）-2,3-二氢-4 H -1-苯并吡喃-4-酮 |
|---|---|
| 英文别名 | (S)-liquiritigenin | CCG-267019 | (2S)-7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one | 4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-,(2S)- | DB03601 | FURUXTVZLHCCNA-AWEZNQCLSA-N | T-BUTOXYBIS(DIMETHYLAMINO)METHANE | Q6557526 |
| 规格或纯度 | 分析标准品 |
| 英文名称 | Liquiritigenin |
| 生化机理 | 甘草素具有抗糖尿病和抗胆汁的特性。它通过抑制活化B细胞核因子卡帕轻链增强子(NF-κB)依赖的诱导性NOS (iNOS)诱导，对Raw246.7细胞产生抗炎活性。甘草素可通过阻挡Hippo/Yes相关蛋白质并转化生长因子-β1 (TGF-β1)/小母抗Dpp (Smad)组分抑制肝纤维化形成。它是一种选择性雌激素受体β调节剂细胞。甘草素通过破坏线粒体膜电位和增加活性氧的产生而诱导SMM-721细胞凋亡。 |
| 储存温度 | 2-8°C储存,充氩 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
甘草素是一种黄酮类化合物和雌激素化合物，发现于甘草（甘草根）的根提取物和其他几种植物。 Liquiritigenin is a flavonoid and an estrogenic compound found in licorice (Glycyrrhizae radix) root extract and several other plants. Application： |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (2S)-7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one |
| INCHI | 1S/C15H12O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-7,14,16-17H,8H2/t14-/m0/s1 |
| InChi Key | FURUXTVZLHCCNA-AWEZNQCLSA-N |
| Smiles | Oc1ccc(cc1)[C@@H]2CC(=O)c3ccc(O)cc3O2 |
| Isomeric SMILES | C1[C@H](OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O |
| PubChem CID | 114829 |
| 分子量 | 256.25 |
| Beilstein号 | 359378 |
| 溶解性 | DMSO: 100 mg/mL (390.24 mM), Sonication is recommended. |
|---|---|
| 密度 | 1.386 |
| 分子量 | 256.250 g/mol |
| XLogP3 | 2.200 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 1 |
| 精确质量Exact Mass | 256.074 Da |
| 单同位素质量Monoisotopic Mass | 256.074 Da |
| 拓扑极表面积Topological Polar Surface Area | 66.800 Ų |
| 重原子数Heavy Atom Count | 19 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 335.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 1 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| WGK Germany | 3 |
|---|---|
| RTECS | DJ2981789 |
| 1. Xiaoran Ning, Yanhui Ni, Jingjing Cao, Huaxing Zhang. (2023) Liquiritigenin Attenuated Collagen-Induced Arthritis and Cardiac Complication via Inflammation and Fibrosis Inhibition in Mice. CHEMICAL & PHARMACEUTICAL BULLETIN, 71 (4): (269-276). [PMID:37005251] [10.1248/cpb.c22-00684] |
| 2. Bin Guo, Xu-Ran Fan, Zhong-Ze Fang, Yun-Feng Cao, Cui-Min Hu, Julin Yang, Yan-Yan Zhang, Rong-Rong He, Xu Zhu, Zhen-Wen Yu, Xiao-Yu Sun, Mo Hong, Lu Yang. (2012) Deglycosylation of Liquiritin Strongly Enhances its Inhibitory Potential Towards UDP-Glucuronosyltransferase (UGT) Isoforms. PHYTOTHERAPY RESEARCH, 27 (8): (1232-1236). [PMID:23065713] [10.1002/ptr.4855] |
| 3. Hui Cao,Xiaojuan Liu,Nataša Poklar Ulrih,Pradeep K Sengupta,Jianbo Xiao. (2018-09-04) Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach.. Food chemistry, 270 (257-263). [PMID:30174044] |
| 4. Na Li,Liyan Liu,Huiqing Luo,Huaqiao Wang,Depo Yang,Feng He. (2020-07-28) Flavanone-Based Fluorophores with Aggregation-Induced Emission Enhancement Characteristics for Mitochondria-Imaging and Zebrafish-Imaging.. Molecules (Basel, Switzerland), 25 ((14)): [PMID:32708080] |
| 5. Yinhuang Gao, Peng Zhao, Chunyan Wang, Keren Fang, Yueqing Pan, Yan Zhang, Zhishuo Miao, Meirong Wang, Minlong Wei, Wei Zou, Menghua Liu, Kang Peng. (2024) Buqi Huoxue Tongnao prescription protects against chronic cerebral hypoperfusion via regulating PI3K/AKT and LXRα/CYP7A1 signaling pathways. PHYTOMEDICINE, 132 (155844). [PMID:38959552] [10.1016/j.phymed.2024.155844] |
| 6. Ziyao Chen, Dongju Zhao, Meng Cheng, Fan Yang, Yining Liu, Jin Chang, Yan Dou. (2024) Female-sensitive multifunctional phytoestrogen nanotherapeutics for tailored management of postmenopausal Alzheimer's disease. Nano Today, 54 (102119). [10.1016/j.nantod.2023.102119] |
| 7. Peng Deng, Qifan Wang, Shengfang Wu, Xiuwen Zhou, Fatih Oz, Qiuming Chen, Zhaojun Wang, Zhiyong He, Jie Chen, Maomao Zeng. (2025) Synergistic effect of spice extracts on multiple hazards formation and sensory markers in beef flavoring. Food Bioscience, 65 (106099). [10.1016/j.fbio.2025.106099] |
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