| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| L101558-1g |
1g |
现货  |
| |
| L101558-5g |
5g |
期货 |
|
| 英文别名 | 58F70VH0HS | NSC14453 | UNII-58F70VH0HS | Lycorine-chloride | Q-100273 | s3800 | BS-42350 | Narcissine hydrochloride | Amarylline hydrochloride | Licorine hydrochloride | SCHEMBL8437600 | Lycorine hydrochloride;Lycorine chloride | (1S,2S,3a1S,12bS)-2,3a1, |
|---|---|
| 规格或纯度 | ≥98%(HPLC) |
| 英文名称 | Lycorine hydrochloride |
| 储存温度 | 2-8°C储存,避光 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
肽转移酶中心（peptidyl transferase center ，PTC）的选择性抑制剂。 |
| 纯度 | ≥98%(HPLC) |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| PubChem SID | 504757560 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | (1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol;hydrochloride |
| INCHI | 1S/C16H17NO4.ClH/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19;/h3-5,11,14-16,18-19H,1-2,6-7H2;1H/t11-,14-,15+,16+;/m0./s1 |
| InChi Key | VUVNTYCHKZBOMV-NVJKKXITSA-N |
| Smiles | C1CN2CC3=CC4=C(C=C3C5C2C1=CC(C5O)O)OCO4.Cl |
| Isomeric SMILES | C1CN2CC3=CC4=C(C=C3[C@H]5[C@H]2C1=C[C@@H]([C@H]5O)O)OCO4.Cl |
| UN Number | 2811 |
| 分子量 | 323.77 |
| Reaxy-Rn | 32694883 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32694883&ln= |
| 敏感性 | 对光敏感 |
|---|---|
| 熔点 | 217°C |
| 分子量 | 323.770 g/mol |
| XLogP3 | |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 0 |
| 精确质量Exact Mass | 323.092 Da |
| 单同位素质量Monoisotopic Mass | 323.092 Da |
| 拓扑极表面积Topological Polar Surface Area | 62.200 Ų |
| 重原子数Heavy Atom Count | 22 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 481.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 4 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 2 |
| 象形图 | GHS06 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H301: 吞咽会中毒 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 |
| WGK Germany | 3 |
| 个人防护装备 | Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges |
| 1. Shuai Meng, Dengke Cheng, Hailing Gu, Yuchen Li, Yukun Qin, Jing Tan, Qijun Li. (2023) Mechanical Force-Induced Color-Variable Luminescence of Carbon Dots in Boric Acid Matrix. MOLECULES, 28 (8): (3388). [PMID:37110622] [10.3390/molecules28083388] |
| 2. Yubin Ji, Miao Yu, Zheng Qi, Di Cui, Guosong Xin, Bing Wang, Weiling Jia, Lin Chang. (2017) Study on apoptosis effect of human breast cancer cell MCF-7 induced by lycorine hydrochloride via death receptor pathway. SAUDI PHARMACEUTICAL JOURNAL, 25 (633). [PMID:28579903] [10.1016/j.jsps.2017.04.036] |
| 3. Ruixiang Yang, Dong Zhu, Hongmei Wen, Anchen Fu, Zihan Zhao, Guoying Dai, Zhaoyi Miao, Yue Hu. (2017) Solid-phase extraction based on a molecularly imprinted polymer nanoshell at the surface of silica nanospheres for the specific enrichment and identification of alkaloids from Crinum asiaticum L. var. sinicum. JOURNAL OF SEPARATION SCIENCE, 40 (5): (1150-1157). [PMID:28044411] [10.1002/jssc.201601116] |
| 4. Jiang Fengqi, Zheng Qiuyan, Zhao Qingsong, Qi Zijuan, Wu Di, Li Wenzhong, Wu Xiaoke, Han Conghui. (2024) Magnetic propelled hydrogel microrobots for actively enhancing the efficiency of lycorine hydrochloride to suppress colorectal cancer. Frontiers in Bioengineering and Biotechnology, 12 [PMID:38449675] [10.3389/fbioe.2024.1361617] |
| 5. Jieqiong Ding, Jie Su, Binhua Luo, Liqiong Ding. (2024) Preparation and Evaluation of Folate Modified PEG-PLLA Nanoparticles Loaded with Lycorine for Glioma Treatment. MOLECULES, 29 (5): (1081). [PMID:38474593] [10.3390/molecules29051081] |
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