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亚油酸

必需的多不饱和脂肪酸。PPAR激活剂。
146篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
L100441-1g
 1g 现货 Stock Image
L100441-5g
 5g 现货 Stock Image
L100441-25g
 25g 现货 Stock Image
L100441-100g
 100g 现货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
查看相关系列
Endogenous Metabolite (978) Metabolic Enzyme/Protease (4889) 代谢物 (8911) 直链不饱和羧酸 (6) 羧酸 C15+ (6) 脂类 (84) 脂质代谢物 (3)
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基本描述

别名 十八碳二烯酸 | 9,12-十八烷二烯酸
英文别名 Fatty Acid 18:2 n-6 | Linoleic acid, >=95% | octadeca-9,12-dienoic acid | Pamolyn 125 (Salt/Mix) | (Z,Z)-9,12-Octadecadienoic acid | C18:2 9c, 12c omega6 todos cis-9,12-octadienoico | Linolic acid | SCHEMBL7067 | 9,12-Octadecadienoic acid, (Z,Z)- | AI3-11
规格或纯度 Moligand™, ≥99%(GC)
英文名称 Linoleic acid
生化机理 亚油酸增加细胞的扩增和PPARα及其靶基因的表达，如PPARα的靶基因酰基辅酶A氧化酶在鸭的肝细胞中的基因表达.必需的多不饱和脂肪酸。PPAR激活剂。诱导细胞凋亡。增强细胞氧化剂状态并诱发线粒体功能障碍。调节炎症过程并调节中性粒细胞功能。
储存温度 避光,-20°C储存
运输条件 超低温冰袋运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

在空气中易氧化变色。蒸馏时分解。能与二甲基甲酰胺油脂溶剂和油类混溶，易溶于乙醚，溶于无水乙醇和石油醚，不溶于甘油和水。碘值181.1。硫氰值96.7。有刺激性。
纯度 ≥99%(GC)

关联靶点（人）

FFAR4 Tchem 游离脂肪酸受体4(Free fatty acid receptor 4) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
FABP3 Tchem 脂肪酸结合蛋白、心脏(Fatty acid-binding protein, heart) (3 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
FABP4 Tchem 脂肪酸结合蛋白、脂肪细胞(Fatty acid-binding protein, adipocyte) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
AKR1C3 Tchem 醛酮还原酶家族 1 个成员 C3(Aldo-keto reductase family 1 member C3) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PPARA Tclin 过氧化物酶体增殖激活受体α(Peroxisome proliferator-activated receptor alpha) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PPARG Tclin 过氧化物酶体增殖激活受体γ(Peroxisome proliferator-activated receptor gamma) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
KCNB1 Tclin 钾电压门控通道亚家族 B 成员 1(Potassium voltage-gated channel subfamily B member 1) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP19A1 Tclin Cytochrome P450 19A1 (6099 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PPARA Tclin Peroxisome proliferator-activated receptor alpha (9197 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RXRA Tclin Retinoid X receptor alpha (3637 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FABP4 Tchem Fatty acid binding protein adipocyte (764 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DUSP3 Tchem Dual specificity protein phosphatase 3 (1161 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR1H4 Tclin Bile acid receptor FXR (6228 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTPN7 Tchem Protein-tyrosine phosphatase LC-PTP (886 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TERT Tchem Telomerase reverse transcriptase (2428 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RBP4 Tchem Plasma retinol-binding protein (718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FABP3 Tchem Fatty acid binding protein muscle (214 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HCT-116 (91556 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Lymphoblastoid cell (5959 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FFAR1 Tchem Free fatty acid receptor 1 (4763 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AKR1C3 Tchem Aldo-keto-reductase family 1 member C3 (1414 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FFAR3 Tchem Free fatty acid receptor 3 (304 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
POLL Tbio DNA polymerase lambda (184 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FFAR4 Tchem G-protein coupled receptor 120 (2999 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR4A2 Tchem Nuclear receptor subfamily 4 group A member 2 (460 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
F7 Tchem Coagulation factor VII/tissue factor (740 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SIRT6 Tchem NAD-dependent protein deacetylase sirtuin-6 (671 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Trypsin (394 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ppard Peroxisome proliferator-activated receptor delta (358 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Soat1 Acyl coenzyme A:cholesterol acyltransferase 1 (295 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Phospholipase A2 (8 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Bacillus subtilis (32866 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mycolicibacterium smegmatis (8003 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Caenorhabditis elegans (1055 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Meloidogyne incognita (862 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hepatitis C virus (23859 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RAW264.7 (28094 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RBL-2H3 (1162 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
LOX1.1 Seed lipoxygenase-1 (463 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Lactuca sativa (1092 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Colletotrichum fragariae (147 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Colletotrichum gloeosporioides (560 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Coptotermes formosanus (677 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Agrostis stolonifera (91 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Heterodera zeae (651 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Colletotrichum acutatum (300 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

EC号 200-470-9
分子类型 小分子
IIUPAC Name (9Z,12Z)-octadeca-9,12-dienoic acid
INCHI 1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6-,10-9-
InChi Key OYHQOLUKZRVURQ-HZJYTTRNSA-N
Smiles CCCCCC=CCC=CCCCCCCCC(=O)O
Isomeric SMILES CCCCC/C=C\C/C=C\CCCCCCCC(=O)O
分子量 280.45
Beilstein号 1727101
Reaxy-Rn 1727100
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1727100&ln=

化学和物理性质

密度 0.902
敏感性 对光敏感、对空气敏感、对水分敏感
折光率 1.466
闪点(℃) >113°C
沸点 229-230 °C/16 mmHg
熔点 -5°C
分子量 280.400 g/mol
XLogP3 6.800
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 2
可旋转键计数Rotatable Bond Count 14
精确质量Exact Mass 280.24 Da
单同位素质量Monoisotopic Mass 280.24 Da
拓扑极表面积Topological Polar Surface Area 37.300 Ų
重原子数Heavy Atom Count 20
形式电荷Formal Charge 0
复杂度Complexity 267.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 2
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 2
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

WGK Germany 1
RTECS RF9990000
Merck Index 5505
个人防护装备 Eyeshields,Gloves

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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批号(Lot Number) 证书类型 货号
H2522556 分析证书 L100441
H2522557 分析证书 L100441
H2522566 分析证书 L100441
H2522567 分析证书 L100441
C2514343 分析证书 L100441
C2514382 分析证书 L100441
H2501095 分析证书 L100441
C2514384 分析证书 L100441
C2514386 分析证书 L100441
A2403412 分析证书 L100441
A2403413 分析证书 L100441
A2403414 分析证书 L100441
H2430018 分析证书 L100441
B2307537 分析证书 L100441
B2307539 分析证书 L100441
B2307626 分析证书 L100441
J2429223 分析证书 L100441
K2215804 分析证书 L100441
K2215782 分析证书 L100441
K2215801 分析证书 L100441
K2215802 分析证书 L100441
K2215803 分析证书 L100441

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此产品的引用文献

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引用文献

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3. Hiroo Kawajiri,Linda C Hsi,Hideki Kamitani,Hiroshi Ikawa,Mark Geller,Toni Ward,Thomas E Eling,Wayne C Glasgow.  (2002-01-29)  Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity..  Archives of biochemistry and biophysics,  398  ((1)): (51-60).  [PMID:11811948]
4. Hiroyasu Iso,Shinichi Sato,Utako Umemura,Minako Kudo,Kazuko Koike,Akihiko Kitamura,Hironori Imano,Tomonori Okamura,Yoshihiko Naito,Takashi Shimamoto.  (2002-08-03)  Linoleic acid, other fatty acids, and the risk of stroke..  Stroke,  33  ((8)): (2086-2093).  [PMID:12154268]
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11. Guang Zeng,Sara Holladay,Danielle Langlois,Yunhong Zhang,Yong Liu.  (2013-01-26)  Kinetics of heterogeneous reaction of ozone with linoleic acid and its dependence on temperature, physical state, RH, and ozone concentration..  The journal of physical chemistry. A,  117  ((9)): (1963-1974).  [PMID:23347186]
12. Ashwell R Ndhlala,Mutalib A Aderogba,Bhekumthetho Ncube,Johannes Van Staden.  (2013-02-05)  Anti-oxidative and cholinesterase inhibitory effects of leaf extracts and their isolated compounds from two closely related Croton species..  Molecules (Basel, Switzerland),  18  ((2)): (1916-1932).  [PMID:23377133]
13. Margit M McGowan,Burton L Eisenberg,Lionel D Lewis,Heather M Froehlich,Wendy A Wells,Alan Eastman,Nancy B Kuemmerle,Kari M Rosenkrantz,Richard J Barth,Gary N Schwartz,Zhongze Li,Tor D Tosteson,Bernard B Beaulieu,William B Kinlaw.  (2013-02-19)  A proof of principle clinical trial to determine whether conjugated linoleic acid modulates the lipogenic pathway in human breast cancer tissue..  Breast cancer research and treatment,  138  ((1)): (175-183).  [PMID:23417336]
14. James A Emery,Karen Hermon,Noor K A Hamid,John A Donald,Giovanni M Turchini.  (2013-03-06)  Δ-6 Desaturase substrate competition: dietary linoleic acid (18:2n-6) has only trivial effects on α-linolenic acid (18:3n-3) bioconversion in the teleost rainbow trout..  PloS one,  8  ((2)): (e57463-e57463).  [PMID:23460861]
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