| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| K656238-1ml |
1ml |
期货  |
|
| 别名 | (+)-酮康唑 |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | (+)-Ketoconazole |
| 生化机理 | (+)-酮康唑（(+)-R 41400）是一种咪唑类抗真菌剂，是一种 CYP3A4 抑制剂：(+)-酮康唑（(+)-R 41400）是一种咪唑类抗真菌剂，通常会产生雄激素缺乏的特征，包括性欲减退、妇科炎症、阳痿和性功能障碍。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 产品介绍 |
(+)-Ketoconazole ((+)-R 41400) is an imidazole anti-fungal agent, a CYP3A4 inhibitor.Target: CYP3A4(+)-Ketoconazole, an imidazole anti-fungal agent, has often produced features of androgen deficiency including decreased libido, gynecomastia, impotence, oligospermia, and decreased testosterone levels, in men being treated for chronic mycotic infections .(+)-Ketoconazole also is a cytochrome P450 inhibitor .(+)-Ketoconazole (KTZ), on the antischistosomal potential of these quinolines against Schistosoma mansoni infection by evaluating parasitological, histopathological, and biochemical parameters. Mice were classified into 7 groups: uninfected untreated (I), infected untreated (II), infected treated orally with PZQ (1,000 mg/kg) (III), QN (400 mg/kg) (IV), KTZ (10 mg/kg)+QN as group IV (V), HF (400 mg/kg) (VI), and KTZ (as group V)+HF (as group VI) (VII). KTZ plus QN or HF produced more inhibition (P<0.05) in hepatic CYP450 (85.7% and 83.8%) and CYT b5 (75.5% and 73.5%) activities, respectively, than in groups treated with QN or HF alone. This was accompanied with more reduction in female (89.0% and 79.3%), total worms (81.4% and 70.3%), and eggs burden (hepatic; 83.8%, 66.0% and intestinal; 68%, 64.5%), respectively, and encountering the granulomatous reaction to parasite eggs trapped in the liver .Clinical indications: Candida infection ; Dermatophytosis; FolliculitisFDA Approved Date:Toxicity: teratogenesis; liver injuries; adrenal gland problems |
| EC号 | 265-667-4 |
|---|---|
| 分子类型 | 小分子 |
| Isomeric SMILES | CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OC[C@H]3CO[C@](O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl |
| 关联CAS | 142128-59-4,65277-42-1 |
| UN Number | 2811 |
| MeSH Entry Terms | Ketoconazole;Nizoral;R 41400;R-41400;R41,400;R41400 |
| 分子量 | 531.43 |
| Reaxy-Rn | 634785 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=634785&ln= |
| RTECS | TK7912300 |
|---|
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