| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| K649108-1mg |
1mg |
期货  |
|
| 别名 | 库拉定 |
|---|---|
| 英文别名 | BDBM50366787 | MS-27861 | (2E)-1-[2,4-Dihydroxy-6-methoxy-3-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]phenyl]-3-(2,4-dihydroxyphenyl)-2-propen-1-one | AKOS040761957 | DTXSID501319126 | PIAPWPAWQGDOMN-SXAWMYDMSA-N | HY-121381 | 2-Propen-1-one, 1-[2,4 |
| 规格或纯度 | ≥98% |
| 英文名称 | Kuraridine |
| 生化机理 | Kuraridine 是一种前烯化黄酮醇提取物，提取自 Sophora flavescens 的根部。Kuraridine 对 5xa0 型 cGMP 特异性磷酸二酯酶（PDE5）有抑制作用（IC 50 =0.64 μM）。 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 产品介绍 |
Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens . Kuraridine has an inhibitory effect on cGMP specific phosphodiesterase type 5 ( PDE5 ) ( IC 50 =0.64 μM) In Vitro Kuraridine shows potent inhibitory activity (IC 50 =0.64 μM) against cGMP PDE5 with 2.0- and 12.9-fold selectivity over PDE3 and PDE4, respectively. Kuraridine induces pronounced chloride inward currents in the absence of GABA. Thecurrents does not exceed 10% of the maximal I GABA induced by a saturating GABA concentration (1 mM). Kuraridine induces a concentration–response curves for I GABA enhancement (EC 50 =4.0±2.4 μM) in Xenopus oocytes expressing GABA A receptors composed of α1, β2, and γ2S subunits. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:PDE5 0.64 μM (IC 50 ) |
| 纯度 | ≥98% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (E)-1-[2,4-dihydroxy-6-methoxy-3-[(2R)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]phenyl]-3-(2,4-dihydroxyphenyl)prop-2-en-1-one |
| INCHI | 1S/C26H30O6/c1-15(2)6-7-18(16(3)4)12-20-23(30)14-24(32-5)25(26(20)31)21(28)11-9-17-8-10-19(27)13-22(17)29/h6,8-11,13-14,18,27,29-31H,3,7,12H2,1-2,4-5H3/b11-9+/t18-/m1/s1 |
| InChi Key | PIAPWPAWQGDOMN-SXAWMYDMSA-N |
| Smiles | CC(=CCC(CC1=C(C(=C(C=C1O)OC)C(=O)C=CC2=C(C=C(C=C2)O)O)O)C(=C)C)C |
| Isomeric SMILES | CC(=CC[C@H](CC1=C(C(=C(C=C1O)OC)C(=O)/C=C/C2=C(C=C(C=C2)O)O)O)C(=C)C)C |
| 关联CAS | 34981-25-4 |
| PubChem CID | 44428631 |
| MeSH Entry Terms | kuraridin |
| 分子量 | 438.51 |
| 溶解性 | DMSO : ≥ 100 mg/mL (228.04 mM) |
|---|---|
| 分子量 | 438.500 g/mol |
| XLogP3 | 6.500 |
| 氢键供体数Hydrogen Bond Donor Count | 4 |
| 氢键受体数Hydrogen Bond Acceptor Count | 6 |
| 可旋转键计数Rotatable Bond Count | 9 |
| 精确质量Exact Mass | 438.204 Da |
| 单同位素质量Monoisotopic Mass | 438.204 Da |
| 拓扑极表面积Topological Polar Surface Area | 107.000 Ų |
| 重原子数Heavy Atom Count | 32 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 694.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 1 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 1 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 1 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
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