| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| K424259-1ml |
1ml |
期货  |
|
| 别名 | 4-羟基-2-喹啉甲酸 | 4-羟基喹啉-2-甲酸 | 犬尿喹啉酸水合物 | 4-羟基喹啉-2-羧酸水合物 | ||||
|---|---|---|---|---|---|
| 英文别名 | AMY18102 | BDBM81975 | Oprea1_032085 | Tox21_500716 | HCZHHEIFKROPDY-UHFFFAOYSA- | LP00716 | KYA | 4-Hydroxy-2-quinolincarboxylic acid | 4-Hydroxyquinoline-2-carboxylic acid | BPBio1_001350 | CCRIS 4428 | HMS500P11 | KBio2_001596 | NINDS_000309 | Transtor | ||||
| 规格或纯度 | Moligand™, 10mM in DMSO | ||||
| 英文名称 | Kynurenic acid | ||||
| 生化机理 | 犬尿氨酸（KynA）是 N-甲基-d-天冬氨酸（NMDA）、α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）和凯因酸受体的非选择性拮抗剂。它能阻断凯尼克酸的神经毒性。犬尿氨酸还能阻断烟碱乙酰胆碱受体。它是色氨酸分解途径的副产品。犬尿氨酸是一种神经调节剂，可控制谷氨酸、多巴胺、乙酰胆碱和α-氨基丁酸（GABA）的水平。KynA 控制神经内分泌功能，KynA 水平的改变是抑郁症、精神分裂症、阿尔茨海默氏症和亨廷顿氏症的潜在标志。大脑中正常水平的 KynA 对认知功能至关重要。它是离子型、甘氨酸 β 和 α7 尼古丁受体的内源性拮抗剂。在体内具有神经保护作用。 | ||||
| 储存温度 | -80℃储存 | ||||
| 运输条件 | 超低温冰袋运输 | ||||
| 作用类型 | 激动剂 | ||||
| 作用机制 | GPR35 激动剂 | ||||
| 产品介绍 |
Kynurenic acid is a metabolite of tryptophan in mammals via the kynurenine pathway. Studies have observed that Kynurenic acid acts as a ligand to the GPR35 G protein-coupled receptor. The binding of Kynurenic acid to GPR35 has been noted to affect calcium mobilization and inositol phosphatase synthesis and may indicate potential signaling functions by Kynurenic acid via the GPR35 receptor. Additionally reported to be a broad spectrum, excitatory amino acid (EAA) antagonist. Other studies have reported that Kynurenic acid acts as an antagonist to mammalian ionotropic glutamate receptors especially NMDA (N-methyl-D-aspartate receptors).Kynurenic acid is an inhibitor of AChR α7, GluR and GlyR.
An antagonist of NMDA and AMPA/kainate receptors
Kynurenic acid is a metabolite of tryptophan in mammals via the kynurenine pathway. Studies have observed that Kynurenic acid acts as a ligand to the GPR35 G protein-coupled receptor. The binding of Kynurenic acid to GPR35 has been noted to affect calcium mobilization and inositol phosphatase synthesis and may indicate potential signaling functions by Kynurenic acid via the GPR35 receptor. Additionally reported to be a broad spectrum, excitatory amino acid (EAA) antagonist. Other studies have reported that Kynurenic acid acts as an antagonist to mammalian ionotropic glutamate receptors especially NMDA (N-methyl-D-aspartate receptors).Kynurenic acid is an inhibitor of AChR α7, GluR and GlyR.
An antagonist of NMDA and AMPA/kainate receptors |
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 207-751-5 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | 4-oxo-1H-quinoline-2-carboxylic acid |
| INCHI | 1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14) |
| InChi Key | HCZHHEIFKROPDY-UHFFFAOYSA-N |
| Smiles | C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)O |
| Isomeric SMILES | C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)O |
| 关联CAS | 492-27-3 |
| 分子量 | 189.17 |
| Beilstein号 | 147451 |
| Reaxy-Rn | 474479 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=474479&ln= |
| 熔点 | 275°C |
|---|---|
| 分子量 | 189.170 g/mol |
| XLogP3 | 1.300 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 1 |
| 精确质量Exact Mass | 189.043 Da |
| 单同位素质量Monoisotopic Mass | 189.043 Da |
| 拓扑极表面积Topological Polar Surface Area | 66.400 Ų |
| 重原子数Heavy Atom Count | 14 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 308.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P362: 脱下污染的衣服并洗净后再使用。 P301+P312: 如误吞咽：如感觉不适，呼叫急救中心/医生。 P302+P352: 如皮肤沾染：用水充分清洗。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P332+P313: 如发生皮肤刺激：求医/就诊。 P337+P313: 如仍觉眼刺激：求医/就诊。 P501: 将内容物/容器处理到。。。 |
| WGK Germany | 3 |
| RTECS | VB2080000 |
| Merck Index | 5327 |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
| 1. Shuyuan Cao, Shengjie Hu, Ping Jiang, Zhan Zhang, Lei Li, Qian Wu. (2023) Effects of sulforaphane on breast cancer based on metabolome and microbiome. Food Science & Nutrition, 11 (5): (2277-2287). [PMID:37181316] [10.1002/fsn3.3168] |
| 2. Qiuyang Huang, Xiaoling Zang, Zhiwei Zhang, Hang Yu, Baoyan Ding, Zhuangzhuang Li, Simin Cheng, Xin Zhang, Mustafa R.K. Ali, Xue Qiu, Zhihua Lv. (2023) Study on endogenous inhibitors against PD-L1: cAMP as a potential candidate. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 230 (123266). [PMID:36646351] [10.1016/j.ijbiomac.2023.123266] |
| 3. Hao Liu, Jun-Tao Zhang, Chen-Ye Mou, Yue Hao, Wei Cui. (2022) Involvement of DAAO Overexpression in Delayed Hippocampal Neuronal Death. Cells, 11 (22): (3689). [PMID:36429117] [10.3390/cells11223689] |
| 4. Xiaoxu Cheng, Zifeng Pi, Zhong Zheng, Shu Liu, Fengrui Song, Zhiqiang Liu. (2022) Combined 16S rRNA gene sequencing and metabolomics to investigate the protective effects of Wu-tou decoction on rheumatoid arthritis in rats. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1199 (123249). [PMID:35447521] [10.1016/j.jchromb.2022.123249] |
| 5. Xue-Mei Han, Yan-Jie Qin, Ying Zhu, Xin-Lin Zhang, Nan-Xi Wang, Ying Rang, Xue-Jia Zhai, Yong-Ning Lu. (2019) Development of an underivatized LC-MS/MS method for quantitation of 14 neurotransmitters in rat hippocampus, plasma and urine: Application to CUMS induced depression rats. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 174 (683). [PMID:31288191] [10.1016/j.jpba.2019.06.043] |
| 6. Hao Liu, Meng-Jing Zhao, Zi-Ying Wang, Qiao-Qiao Han, Hai-Yun Wu, Xiao-fang Mao, Yong-Xiang Wang. (2019) Involvement of d-amino acid oxidase in cerebral ischaemia induced by transient occlusion of the middle cerebral artery in mice. BRITISH JOURNAL OF PHARMACOLOGY, 176 (17): (3336-3349). [PMID:31309542] [10.1111/bph.14764] |
| 7. Dezhen Wang, Xinru Wang, Ping Zhang, Yao Wang, Renke Zhang, Jin Yan, Zhiqiang Zhou, Wentao Zhu. (2017) The fate of technical-grade chlordane in mice fed a high-fat diet and its roles as a candidate obesogen. ENVIRONMENTAL POLLUTION, 222 (532). [PMID:28041837] [10.1016/j.envpol.2016.11.028] |
| 8. Dan-Qian Chen,Gang Cao,Hua Chen,Dan Liu,Wei Su,Xiao-Yong Yu,Nosratola D Vaziri,Xiu-Hua Liu,Xu Bai,Li Zhang,Ying-Yong Zhao. (2017-03-28) Gene and protein expressions and metabolomics exhibit activated redox signaling and wnt/β-catenin pathway are associated with metabolite dysfunction in patients with chronic kidney disease.. Redox biology, 12 (505-521). [PMID:28343144] |
| 9. Yu Meng Wang,Wei Yi Wang,Li Yan Sun,Qiang Li,Zhi Jun Zhao,Jian Hu,Rong Yu Zhang,Li Hua Wang. (2020-11-25) Serum Metabolomic Indicates Potential Biomarkers and Metabolic Pathways of Pediatric Kashin-Beck Disease.. Biomedical and environmental sciences : BES, 33 ((10)): (750-759). [PMID:33228834] |
首页
400-620-6333
9篇引用文献 
