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12篇引用文献 
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山奈素
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| K424252-1ml |
1ml |
现货  |
|
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基本描述
| 别名 | 3,5,7-三羟基-4'-甲氧基黄酮 |
|---|---|
| 英文别名 | CCG-267464 | HMS3746E09 | SQFSKOYWJBQGKQ-UHFFFAOYSA-N | 3,5,7-Trihydroxy-4'-methoxyflavone | 3,5,7-Trihydroxy-4'-methoxy-Flavone | 5-18-05-00253 (Beilstein Handbook Reference) | BRN 0305378 | LMPK12110563 | NSC 407294 | WLN: T66 BO EVJ CR DO1& DQ GQ IQ | |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Kaempferide |
| 生化机理 | 山奈苷是一种 O-甲基化的黄酮醇，是一种化合物。它存在于高良姜（Kaempferia galanga）中。山奈酚 4'-O-甲基转移酶利用 S-腺苷-L-蛋氨酸和山奈酚生成 S-腺苷-L-高半胱氨酸和山奈苷。P-糖蛋白。摘自维基百科。 |
| 储存温度 | 避光,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Kaempferide is a naturally occurring, O-methylated flavonol found in Kaempferia galanga. It exhibits a variety of pharmacological effects such as anti-inflammatory, anti-viral, anti-oxidant, anti-bacterial and antitumor properties. |
关联靶点（人）
CYP1A2
Tchem
细胞色素 P450 1A2(Cytochrome P450 1A2)
(1 活性数据)
CYP1B1
Tchem
细胞色素 P450 1B1(Cytochrome P450 1B1)
(2 活性数据)
CYP1A1
Tchem
细胞色素 P450 1A1(Cytochrome P450 1A1)
(2 活性数据)
MAOA
Tclin
胺氧化酶[含黄素]A(Amine oxidase [flavin-containing] A)
(1 活性数据)
TYR
Tclin
Tyrosinase
(717 活性数据)
MAOA
Tclin
Monoamine oxidase A
(11911 活性数据)
CYP1B1
Tchem
Cytochrome P450 1B1
(1148 活性数据)
CYP1A1
Tchem
Cytochrome P450 1A1
(1169 活性数据)
TOP2B
Tclin
DNA topoisomerase II beta
(959 活性数据)
CYP1A2
Tchem
Cytochrome P450 1A2
(26471 活性数据)
HT-1080
(3966 活性数据)
HT-29
(80576 活性数据)
A549
(127892 活性数据)
HCT-116
(91556 活性数据)
Monocyte
(474 活性数据)
KB
(17409 活性数据)
HeLa
(62764 活性数据)
SETD7
Tchem
Histone-lysine N-methyltransferase SETD7
(390 活性数据)
ABCG2
Tchem
ATP-binding cassette sub-family G member 2
(4927 活性数据)
NFKB2
Tchem
Nuclear factor NF-kappa-B complex
(2307 活性数据)
关联靶点（其它种属）
Abcb1b
P-glycoprotein 1 (174 活性数据)
Abcb1a
P-glycoprotein 3 (492 活性数据)
Helicobacter pylori (3113 活性数据)
Pseudomonas aeruginosa (123386 活性数据)
Salmonella typhimurium (15756 活性数据)
Staphylococcus aureus (210822 活性数据)
Staphylococcus epidermidis (22802 活性数据)
Escherichia coli (133304 活性数据)
Proteus mirabilis (3894 活性数据)
Mycobacterium tuberculosis (203094 活性数据)
Bacillus cereus (7522 活性数据)
Gallus gallus (1187 活性数据)
Hepatitis C virus (23859 活性数据)
Stenotrophomonas maltophilia (1743 活性数据)
B16 (5829 活性数据)
L929 (3802 活性数据)
Avian myoblastosis virus polyprotein II (68 活性数据)
rep
Replicase polyprotein 1ab (378 活性数据)
Micrococcus flavus (568 活性数据)
Nfe2l2
Nuclear factor erythroid 2-related factor 2 (214 活性数据)
gyrB
DNA gyrase (2092 活性数据)
SARS-CoV-2 (38078 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| EC号 | 207-738-4 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | 3,5,7-trihydroxy-2-(4-methoxyphenyl)chromen-4-one |
| INCHI | 1S/C16H12O6/c1-21-10-4-2-8(3-5-10)16-15(20)14(19)13-11(18)6-9(17)7-12(13)22-16/h2-7,17-18,20H,1H3 |
| InChi Key | SQFSKOYWJBQGKQ-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O |
| Isomeric SMILES | COC1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O |
| 分子量 | 300.26 |
| Beilstein号 | 305378 |
| Reaxy-Rn | 305378 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=305378&ln= |
化学和物理性质
| 敏感性 | 对光线、空气、湿度敏感 |
|---|---|
| 分子量 | 300.260 g/mol |
| XLogP3 | 2.200 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 6 |
| 可旋转键计数Rotatable Bond Count | 2 |
| 精确质量Exact Mass | 300.063 Da |
| 单同位素质量Monoisotopic Mass | 300.063 Da |
| 拓扑极表面积Topological Polar Surface Area | 96.200 Ų |
| 重原子数Heavy Atom Count | 22 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 465.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
| WGK Germany | 3 |
|---|---|
| RTECS | LK6915000 |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
引用文献
| 1. Shaoyan Zhang, Jinfeng Ning, Qingqing Wang, Wei Wang. (2023) Fluorescence enhancement of flavonoids and its application in ingredient determination for some traditional Chinese medicines by CE-LIF. Analytical Methods, 15 (24): (2964-2970). [PMID:37309583] [10.1039/D3AY00486D] |
| 2. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin. Food & Function, 13 (9): (5061-5074). [PMID:35404372] [10.1039/D1FO03816H] |
| 3. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song. (2020) Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 239 (118519). [PMID:32480277] [10.1016/j.saa.2020.118519] |
| 4. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang. (2020) Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations. FOOD CHEMISTRY, 323 (126807). [PMID:32330646] [10.1016/j.foodchem.2020.126807] |
| 5. Rongxia Liu, Chaonan Su, Yumeng Xu, Kangle Shang, Kang Sun, Caihong Li, Jing Lu. (2020) Identifying potential active components of walnut leaf that action diabetes mellitus through integration of UHPLC-Q-Orbitrap HRMS and network pharmacology analysis. JOURNAL OF ETHNOPHARMACOLOGY, 253 (112659). [PMID:32058009] [10.1016/j.jep.2020.112659] |
| 6. Yu-Mei Zhao, Lv-Huan Wang, Si-Fan Luo, Qi-Qin Wang, Ruin Moaddel, Ting-Ting Zhang, Zheng-Jin Jiang. (2018) Magnetic beads-based neuraminidase enzyme microreactor as a drug discovery tool for screening inhibitors from compound libraries and fishing ligands from natural products. JOURNAL OF CHROMATOGRAPHY A, 1568 (123). [PMID:30005943] [10.1016/j.chroma.2018.07.031] |
| 7. Jing-Yi Hao, Yi Wan, Xiao-Hui Yao, Wei-Guo Zhao, Run-Ze Hu, Cong Chen, Long Li, Dong-Yang Zhang, Guo-Hua Wu. (2018) Effect of different planting areas on the chemical compositions and hypoglycemic and antioxidant activities of mulberry leaf extracts in Southern China. PLoS One, 13 (6): (e0198072). [PMID:29944667] [10.1371/journal.pone.0198072] |
| 8. Lite Yang, Bingjie Xu, Huili Ye, Faqiong Zhao, Baizhao Zeng. (2017) A novel quercetin electrochemical sensor based on molecularly imprinted poly(para-aminobenzoic acid) on 3D Pd nanoparticles-porous graphene-carbon nanotubes composite. SENSORS AND ACTUATORS B-CHEMICAL, 251 (601). [10.1016/j.snb.2017.04.006] |
| 9. Yang Huang, Ying Feng, Guangyun Tang, Minyi Li, Tingting Zhang, Marianne Fillet, Jacques Crommen, Zhengjin Jiang. (2017) Development and validation of a fast SFC method for the analysis of flavonoids in plant extracts. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 140 (384). [PMID:28347593] [10.1016/j.jpba.2017.03.012] |
| 10. Shuzhen Yang, Jie Zhou, Dongmei Li, Chunyu Shang, Litao Peng, Siyi Pan. (2017) The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum. FOOD CHEMISTRY, 224 (26). [PMID:28159264] [10.1016/j.foodchem.2016.12.001] |
| 11. Qi Yun, Qingwang Liu, Cunyong He, Xiaohua Ma, Xiaoli Gao, Amer Talbi, Jianping Zhou. (2014) UPLC-Q-TOF/MS characterization, HPLC fingerprint analysis and species differentiation for quality control of Nigella glandulifera Freyn et Sint seeds and Nigella sativa L. seeds. Analytical Methods, 6 (13): (4845-4852). [10.1039/C4AY00775A] |
| 12. Hui Cao, Xiaohui Jing, Donghui Wu, Yujun Shi. (2013) Methylation of genistein and kaempferol improves their affinities for proteins. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, [PMID:23311465] [10.3109/09637486.2012.759186] |