| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| I655810-1ml |
1ml |
期货  |
|
| 别名 | 细胞间粘附分子-1-合-1 |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | ICAM-1-IN-1 |
| 生化机理 | ICAM-1-IN-1 是一种强效的 E-选择素和 ICAM-1 选择性抑制剂，IC50 值分别为 7 和 5 nM。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 产品介绍 |
ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC 50 values of 7 and 5 nM, respectively. In Vivo ICAM-1-IN-1 shows significant efficacy in a rat rheumatoid arthritis model and in a mouse asthma model. ICAM-1-IN-1 reduces the width of inflamed ankles after the ninth day following treatment, but shows no efficacy in the acute phase. Treatment with ICAM-1-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 7 nM (E-selectin), 5 nM (ICAM-1) |
| 分子类型 | 小分子 |
|---|---|
| Isomeric SMILES | CNC(=O)C1=CC2=C(S1)C=NC=C2OC3=CC=C(C=C3)Br |
| PubChem CID | 10361323 |
| 分子量 | 363.23 |
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