| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| I424190-1ml |
1ml |
现货  |
|
| 别名 | 前胡内酯 | 白芷乙素 | 前胡素 | 8-(3-甲基-2-丁烯氧基)补骨脂素 | 8-异戊烯氧基补骨脂素 | 白茅苷 | 9-[(3-甲基-2-丁烯-1-基)氧]-7H-呋喃并[3,2-g]色满-7-酮 |
|---|---|
| 英文别名 | NCGC00095209-05 | SCHEMBL50437 | 9-(3-Methyl-2-butenyloxy)-7-oxofuro[3,2-g]chromene | 9-(3-Methyl-but-2-enyloxy)-furo[3,2-g]chromen-7-one | 9-(3-Methylbut-2-enyloxy)furo[3,2-g]chromen-7-one | HMS2218G08 | SDCCGMLS-0066373.P001 | HMS3885G06 | NCGC00095209- |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Imperatorin |
| 生化机理 | 欧前胡素是p38、ERK路径的调控因子。欧前胡素增加BMP-2的表达(mRNA) ,体外研究证实欧前胡素增加体内骨质密度/体积和矿物化。细胞周期蛋白D1抑制剂。诱导细胞周期停滞在G1。激活胱天蛋白酶9并诱导凋亡。抑制HIV-1复制。TRPV1激动剂弱（EC 50 = 13μM）。显示出抗增殖作用。在体内显示镇痛作用。口服具有活性 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
属呋喃香豆素类化合物。为棱柱状结晶（由乙醚）、长细针晶（由热水），易溶于氯仿，可溶于苯、乙醇、乙醚和苛性碱溶液，不溶于冷水。Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. Studies indicate that the transcription factor Sp1 is essential in the inhibitory functions of Imperatorin. In addition, Imperatorin inhibits cyclin D1 expression and stops the cell cycle at G1. These studies also suggest that Imperatorin suppresses HIV-1 replication in primary T lymphocytes and transformed cell lines. Furthermore, it has been suggested that the inhibitory effects of Imperatorin on HIV-1 at the transcriptional level can be monitored effectively in HeLa cells. Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway. Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. Studies indicate that the transcription factor Sp1 is essential in the inhibitory functions of Imperatorin. In addition, Imperatorin inhibits cyclin D1 expression and stops the cell cycle at G1. These studies also suggest that Imperatorin suppresses HIV-1 replication in primary T lymphocytes and transformed cell lines. Furthermore, it has been suggested that the inhibitory effects of Imperatorin on HIV-1 at the transcriptional level can be monitored effectively in HeLa cells. Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| PubChem SID | 504751913 |
|---|---|
| EC号 | 207-581-1 |
| 分子类型 | 小分子 |
| IIUPAC Name | 9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one |
| INCHI | 1S/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H3 |
| InChi Key | OLOOJGVNMBJLLR-UHFFFAOYSA-N |
| Smiles | CC(=CCOC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)C |
| Isomeric SMILES | CC(=CCOC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)C |
| 分子量 | 270.28 |
| Reaxy-Rn | 249728 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=249728&ln= |
| 敏感性 | 对热敏感 |
|---|---|
| 熔点 | 97.0 to 101.0 °C |
| 分子量 | 270.280 g/mol |
| XLogP3 | 3.400 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 3 |
| 精确质量Exact Mass | 270.089 Da |
| 单同位素质量Monoisotopic Mass | 270.089 Da |
| 拓扑极表面积Topological Polar Surface Area | 48.700 Ų |
| 重原子数Heavy Atom Count | 20 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 436.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| WGK Germany | 3 |
|---|---|
| Merck Index | 4925 |
| 个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
首页
400-620-6333
