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氯化高铁血红素

43篇引用文献 COA COA
    级别和纯度:
  • BioReagent
    •
  • ≥96%(HPLC)
  • from Porcine
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货号 (SKU) 包装规格 是否现货 价格 数量
H755736-1g
 1g 现货 Stock Image
H755736-5g
 5g 现货 Stock Image
H755736-25g
 25g 现货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
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main product photo

基本描述

别名 AKOS025146500 | 血晶素 | 血晶质 | 氯原卟啉IX铁(III), 高铁血红素(氯) | 氯化高铁血红素 | 氯(原卟啉酸)铁(III) | 高铁原卟啉IX氯
英文别名 Panhematin | 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(3+);chloride | Q425165 | HEMIN [JAN] | Hemin chloride is known as an oxidized form of heme. | HEMIN [WHO-DD]
规格或纯度 BioReagent, ≥96%(HPLC), from Porcine
英文名称 Hemin
生化机理 高铁血红素是经氧化血红素，是一系列蛋白质的一种含铁的辅基基团。游离血红素在溶血后从血红蛋白中释放出来，具有促炎作用，有助于铁源活性氧的生成。游离血红素水平可在各种病理条件下上调，并可导致各种炎症条件，包括血管疾病、肾功能衰竭和免疫介导的疾病。

高铁血红素可用于研究血红素加氧酶1 (HO-1)的表达和抑制以及HO-1的活性。 血凝素是生长流感嗜血杆菌所必需的“X因子”。
储存温度 2-8°C储存,避光,充氩
运输条件 冰袋运输
产品介绍

高铁血红素应用于以下应用中：研究菌株和生长条件用于短期菌落测定(培养基由血红素和其他成分组成)细胞转染它可用于分析MMV(抗疟药物)疟疾盒化合物对β-血红蛋白形成的抑制作用。

Hemin is used for the following applications:

  • To study bacterial strains and growth conditions
  • Used in short-term colony assays (the culture medium consists of hemin along with other components)
  • Cell transfections

It may be used in β-hematin formation assay for analyzing the inhibitory activity of MMV (Medicines for Malaria Venture) Malaria Box compounds against the formation of β-hematin.

纯度 ≥96%(HPLC)

名称和识别符

EC号 240-140-1
分子类型 细胞或组织提取物
IIUPAC Name 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(3+);chloride
INCHI 1S/C34H34N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3
InChi Key BTIJJDXEELBZFS-UHFFFAOYSA-K
Smiles CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C)C=C)C)C=C)C)CCC(=O)O)CCC(=O)O.[Cl-].[Fe+3]
Isomeric SMILES CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C)C=C)C)C=C)C)CCC(=O)O)CCC(=O)O.[Cl-].[Fe+3]
PubChem CID 455658
分子量 651.96
Beilstein号 5229914

化学和物理性质

溶解性 Soluble in dilute ammonia water,trimethylamine, p-toluidine, dimethylaniline and 0.1-1.0 N NaOH. Insoluble in water.
敏感性 对光线敏感
熔点 300℃
分子量 651.900 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count 2
氢键受体数Hydrogen Bond Acceptor Count 9
可旋转键计数Rotatable Bond Count 8
精确质量Exact Mass 651.146 Da
单同位素质量Monoisotopic Mass 651.146 Da
拓扑极表面积Topological Polar Surface Area 102.000 Ų
重原子数Heavy Atom Count 44
形式电荷Formal Charge 0
复杂度Complexity 1010.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 3

安全和危险性（GHS）

象形图 GHS07,   GHS08
信号词 危险
危险声明

H315: 引起皮肤刺激

H317: 可能引起皮肤过敏反应

H319: 引起严重眼睛刺激

H334: 吸入可能引起过敏或哮喘病症状或呼吸困难

H335: 可能引起呼吸道刺激
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P264: 处理后要彻底洗手。

P271: 仅在室外或通风良好的地方使用。

P272: 被污染的工作服不允许离开工作场所

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P284: 如果通风不良，请佩戴呼吸防护装置。

P321: 特殊处理（请参阅此标签上的...）。

P302+P352: 如皮肤沾染：用水充分清洗。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P405: 密闭存放

P403+P233: 存放在通风良好的地方。保持容器密闭。

P501: 将内容物/容器处理到。。。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。

P319: 如果你感到不适，请寻求医疗帮助。

P342+P316: 如果出现呼吸道症状：立即寻求急救。

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批号(Lot Number) 证书类型 货号
F2517686 分析证书 H755736
F2517671 分析证书 H755736
F2517673 分析证书 H755736
F2517683 分析证书 H755736
F2517694 分析证书 H755736

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