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氯化血红素

229篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
H140872-1g
 1g 现货 Stock Image
H140872-5g
 5g 现货 Stock Image
H140872-25g
 25g 现货 Stock Image
H140872-100g
 100g 现货 Stock Image
H140872-500g
 500g 现货 Stock Image
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基本描述

别名 血晶素 | 血晶质 | 氯化高铁血红素 | 氯原卟啉IX铁(III), 高铁血红素(氯) | 氯(原卟啉酸)铁(III) | 高铁原卟啉IX氯
英文别名 Panhematin | 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(3+);chloride | Q425165 | HEMIN [JAN] | AKOS025146500 | Hemin chloride is known as an oxidized form of heme. | HEMIN [WHO-DD] | hemin c
规格或纯度 Moligand™, ≥95%
英文名称 Hemin
生化机理 高铁血红素是经氧化血红素，是一系列蛋白质的一种含铁的辅基基团。游离血红素在溶血后从血红蛋白中释放出来，具有促炎作用，有助于铁源活性氧的生成。游离血红素水平可在各种病理条件下上调，并可导致各种炎症条件，包括血管疾病、肾功能衰竭和免疫介导的疾病。高铁血红素可用于研究血红素加氧酶1 (HO-1)的表达和抑制以及HO-1的活性。 血凝素是生长流感嗜血杆菌所必需的“X因子”.
储存温度 2-8°C储存
运输条件 冰袋运输
产品介绍

营养增补剂（铁质强化剂），现代医学公认的防治缺铁性贫血、吸收率高、效果好的往下生物铁源，无铁腥味，不刺激肠胃。是生产天然补铁食品、药品、保健品、化妆品的首选原料。 高铁血红素应用于以下应用中：研究菌株和生长条件 · 用于短期菌落测定(培养基由血红素和其他成分组成) · 细胞转染 它可用于分析MMV(抗疟药物)疟疾盒化合物对β-血红蛋白形成的抑制作用。

Hemin chloride, a heme oxygenase 1 inducer, is a porphyrin complex that is derived from erythrocytes. At a concentration of 20 mM Hemin chloride demonstrated the significance of heme in myotube maturation by increasing size, number, cross-striations, and contraction frequency and strength of myotubes. The compound has been observed to induce cGMP formation through induction of guanylate cyclase. Hemin chloride has been noted to stimulate calcium-dependent K+ channels and modulate fluid transport and Na+ in the loop of henle in rat studies. Hemin has also been documented to give rise to active chloride secretion in Caco-2 cells. In cadmium injured rat testes, hemin chloride demonstrated anti-apoptotic, antiinflamatory and antioxidant properties. Through reactive oxygen species of ERK-1/2-Elk-1 and NF-κB, hemin chloride has been shown to upregulate Egr-1 expression in vascular smooth muscle cells. It has also been used in solution to prepare agar medium for the cultivation of distinct bacteria.
A porphyrin complex heme oxygenase-1 inducer with acts in cellular protection and control
纯度 ≥95%

名称和识别符

PubChem SID 488189872
EC号 240-140-1
分子类型 小分子
IIUPAC Name 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(3+);chloride
INCHI 1S/C34H34N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3
InChi Key BTIJJDXEELBZFS-UHFFFAOYSA-K
Smiles CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C)C=C)C)C=C)C)CCC(=O)O)CCC(=O)O.[Cl-].[Fe+3]
Isomeric SMILES CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C)C=C)C)C=C)C)CCC(=O)O)CCC(=O)O.[Cl-].[Fe+3]
PubChem CID 455658
分子量 651.96
Beilstein号 5229914

化学和物理性质

溶解性 Soluble in dilute ammonia water,trimethylamine, p-toluidine, dimethylaniline and 0.1-1.0 N NaOH. Insoluble in water.
敏感性 对光线敏感
熔点 300℃
分子量 651.900 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count 2
氢键受体数Hydrogen Bond Acceptor Count 9
可旋转键计数Rotatable Bond Count 8
精确质量Exact Mass 651.146 Da
单同位素质量Monoisotopic Mass 651.146 Da
拓扑极表面积Topological Polar Surface Area 102.000 Ų
重原子数Heavy Atom Count 44
形式电荷Formal Charge 0
复杂度Complexity 1010.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 3

安全和危险性（GHS）

象形图 GHS07,   GHS08
信号词 危险
危险声明

H315: 引起皮肤刺激

H317: 可能引起皮肤过敏反应

H319: 引起严重眼睛刺激

H334: 吸入可能引起过敏或哮喘病症状或呼吸困难

H335: 可能引起呼吸道刺激
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P264: 处理后要彻底洗手。

P271: 仅在室外或通风良好的地方使用。

P272: 被污染的工作服不允许离开工作场所

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P284: 如果通风不良，请佩戴呼吸防护装置。

P321: 特殊处理（请参阅此标签上的...）。

P302+P352: 如皮肤沾染：用水充分清洗。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P405: 密闭存放

P403+P233: 存放在通风良好的地方。保持容器密闭。

P501: 将内容物/容器处理到。。。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。

P319: 如果你感到不适，请寻求医疗帮助。

P342+P316: 如果出现呼吸道症状：立即寻求急救。

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批号(Lot Number) 证书类型 货号
E2514630 分析证书 H140872
E2514631 分析证书 H140872
E2509315 分析证书 H140872
E2509316 分析证书 H140872
F2426079 分析证书 H140872
F2426487 分析证书 H140872
G2402284 分析证书 H140872
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G2402286 分析证书 H140872
I2313431 分析证书 H140872
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I2313433 分析证书 H140872
I2313434 分析证书 H140872
I2313435 分析证书 H140872
K2408179 分析证书 H140872
J2430194 分析证书 H140872
K2429098 分析证书 H140872
G2429072 分析证书 H140872
A2419050 分析证书 H140872
G2318711 分析证书 H140872
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G2318728 分析证书 H140872
G2318732 分析证书 H140872
G2318733 分析证书 H140872
G2318803 分析证书 H140872
G2318805 分析证书 H140872
G2318811 分析证书 H140872
C2202467 分析证书 H140872
C2202469 分析证书 H140872
C2202478 分析证书 H140872
C2202479 分析证书 H140872
C2202480 分析证书 H140872
A2305198 分析证书 H140872
F23171169 分析证书 H140872
G2304040 分析证书 H140872
B2327048 分析证书 H140872
D23141115 分析证书 H140872
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引用文献

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