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橙皮苷

22篇引用文献 COA COA
    级别和纯度:
  • ≥80%
有货

库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
H432824-5g
 5g 现货 Stock Image
H432824-25g
 25g 现货 Stock Image
H432824-100g
 100g 期货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
查看相关系列
Apoptosis (7108) Autophagy (2848) Endogenous Metabolite (978) Glucose Metabolism (3713) Immunology/Inflammation (1938) Metabolic Enzyme/Protease (4889) NF-κB (756) Reactive Oxygen Species (316) 代谢物 (8911) 类黄酮 (8) 苯丙醇类和聚酮类 (1)
main product photo

基本描述

别名 3',5,7-三羟基4'-甲氧基黄酮7-芸香, 橙皮素 7-鼠李糖苷, 橙皮素-7-芸香糖苷
英文别名 (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside | CHEBI:28775 | DIOSVEIN | EINECS 208-288-1 | Hesperetin 7 Rhamnoglucoside | Q385937 | D01038 | hesperidin | DTXSID9
规格或纯度 ≥80%
英文名称 Hesperidin
生化机理 从柑橘中提取的黄酮类植物化学物质。为橙皮素的鼠李糖苷（芸香苷）。
储存温度 2-8°C储存,充氩
运输条件 冰袋运输
产品介绍

应用

对橙皮苷和橙皮素（甙元）与 DMPC 脂质体的行为研究发现，甙元穿透更深，与“膜”结合更强。这可能解释了一般生物类黄酮苷元生物利用度较好的原因。


其他说明

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. H5254.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To lear

Application

Studies of the behavior of hesperidin and hesperetin (the aglycone) with DMPC liposomes find the aglycone penetrates more deeply and binds more strongly to the "membrane." This may explain the better bioavailability of bioflavonoid aglycones in general.


Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. H5254.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit .com/metlin.
纯度 ≥80%

关联靶点（人）

F2 Tclin Thrombin (11687 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FABP4 Tchem Fatty acid binding protein adipocyte (764 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
POLB Tchem DNA polymerase beta (23632 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
APP Tclin Amyloid-beta A4 protein (8510 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HPSE Tchem Heparanase (634 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BACE1 Tchem Beta-secretase 1 (15641 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Caco-2 (12174 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DLD-1 (17511 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HT-29 (80576 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
A549 (127892 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
H9 (1832 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Monocyte (474 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HL (112 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
POLI Tchem DNA polymerase iota (116820 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
POLH Tchem DNA polymerase eta (21678 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KDM4A Tchem Lysine-specific demethylase 4A (52245 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KDM1A Tchem Lysine-specific histone demethylase 1 (3916 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CTDSP1 Tchem Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (1031 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CACNA1B Tclin Voltage-gated N-type calcium channel alpha-1B subunit/Amyloid beta A4 precursor protein-binding family A member 1 (925 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

NA Neuraminidase (1107 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Chlamydia pneumoniae (241 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Proteus vulgaris (5823 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Salmonella typhimurium (15756 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Proteus mirabilis (3894 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Bacillus subtilis (32866 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mycobacterium tuberculosis (203094 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Human immunodeficiency virus 1 (70413 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
3T3-L1 (3664 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CCRF S-180 (1031 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
L1210 (27553 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CALM Calmodulin (71 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BCHE Cholinesterase (8742 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Slco1a5 Solute carrier organic anion transporter family member 1A5 (48 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504751977
EC号 208-288-1
分子类型 小分子
IIUPAC Name (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one
INCHI 1S/C28H34O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-7,10,17,19,21-30,32-37H,8-9H2,1-2H3/t10-,17-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1
InChi Key QUQPHWDTPGMPEX-QJBIFVCTSA-N
Smiles COc1ccc(cc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2
Isomeric SMILES C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=CC(=C4C(=O)C[C@H](OC4=C3)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O
分子量 610.56
Beilstein号 75140

化学和物理性质

敏感性 对空气敏感
熔点 250-255°C
分子量 610.600 g/mol
XLogP3 -1.100
氢键供体数Hydrogen Bond Donor Count 8
氢键受体数Hydrogen Bond Acceptor Count 15
可旋转键计数Rotatable Bond Count 7
精确质量Exact Mass 610.19 Da
单同位素质量Monoisotopic Mass 610.19 Da
拓扑极表面积Topological Polar Surface Area 234.000 Ų
重原子数Heavy Atom Count 43
形式电荷Formal Charge 0
复杂度Complexity 940.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 11
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

信号词 警告
危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
WGK Germany 3
Merck Index 4671
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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批号(Lot Number) 证书类型 货号
A2517211 分析证书 H432824
A2517212 分析证书 H432824
A2517213 分析证书 H432824
A2517215 分析证书 H432824
E2508048 分析证书 H432824
G2416108 分析证书 H432824
G2416109 分析证书 H432824
D2419029 分析证书 H432824
J2424336 分析证书 H432824
E2312188 分析证书 H432824
E2312200 分析证书 H432824
E2312212 分析证书 H432824
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C2413034 分析证书 H432824

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此产品的引用文献

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引用文献

1. F La Torre,A P Nicolai,M Otti.  (2000-03-29)  [Hemorrhoids and conservative treatment. Review of the literature on the use of diosmin and micronized hesperidin]..  Minerva chirurgica,  54  ((12)): (909-916).  [PMID:10736998]
2. A Garg,S Garg,L J Zaneveld,A K Singla.  (2001-12-18)  Chemistry and pharmacology of the Citrus bioflavonoid hesperidin..  Phytotherapy research : PTR,  15  ((8)): (655-669).  [PMID:11746857]
3. Takuji Tanaka,Takahiro Tanaka,Mayu Tanaka,Toshiya Kuno.  (2011-12-17)  Cancer chemoprevention by citrus pulp and juices containing high amounts of β-cryptoxanthin and hesperidin..  Journal of biomedicine & biotechnology,  2012  (516981-516981).  [PMID:22174562]
4. Binit Kumar,Suresh Kumar Gupta,B P Srinivasan,Tapas Chandra Nag,Sushma Srivastava,Rohit Saxena.  (2012-09-13)  Hesperetin ameliorates hyperglycemia induced retinal vasculopathy via anti-angiogenic effects in experimental diabetic rats..  Vascular pharmacology,  57  ((5-6)): (201-207).  [PMID:22967957]
5. Leandro C Souza,Marcelo G de Gomes,André T R Goes,Lucian Del Fabbro,Carlos B Filho,Silvana P Boeira,Cristiano R Jesse.  (2012-09-22)  Evidence for the involvement of the serotonergic 5-HT(1A) receptors in the antidepressant-like effect caused by hesperidin in mice..  Progress in neuro-psychopharmacology & biological psychiatry,  40  (103-109).  [PMID:22996046]
6. Baoshun Zhang,Tingting Chen,Zhu Chen,Mingxue Wang,Dengyu Zheng,Jinfeng Wu,Xiaofei Jiang,Xuegang Li.  (2012-10-17)  Synthesis and anti-hyperglycemic activity of hesperidin derivatives..  Bioorganic & medicinal chemistry letters,  22  ((23)): (7194-7197).  [PMID:23067551]
7. Andreia F M Furtado,Mario A P Nunes,Maria H L Ribeiro.  (2012-10-31)  Hesperidinase encapsulation towards hesperitin production targeting improved bioavailability..  Journal of molecular recognition : JMR,  25  ((11)): (595-603).  [PMID:23108619]
8. Jinhua Li,Sumin Wang.  (2012-12-12)  Molecular spectroscopic on interaction between Methyl hesperidin and Buman serum albumin..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  102  (200-204).  [PMID:23220657]
9. Ousmane Ilboudo,Issa Tapsoba,Yvonne L Bonzi-Coulibaly,Pascal Gerbaux.  (2012-12-12)  Targeting structural motifs of flavonoid diglycosides using collision-induced dissociation experiments on flavonoid/Pb2+ complexes..  European journal of mass spectrometry (Chichester, England),  18  ((5)): (465-473).  [PMID:23221119]
10. Julia M Assini,Erin E Mulvihill,Murray W Huff.  (2012-12-21)  Citrus flavonoids and lipid metabolism..  Current opinion in lipidology,  24  ((1)): (34-40).  [PMID:23254473]
11. Lin Tang,Wanteng Jia.  (2012-12-22)  A comparison study on the binding of hesperetin and luteolin to bovine serum albumin by spectroscopy..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  103  (114-119).  [PMID:23257337]
12. Hitomi Ichinose,Zui Fujimoto,Satoshi Kaneko.  (2013-01-08)  Characterization of an α-L-Rhamnosidase from Streptomyces avermitilis..  Bioscience, biotechnology, and biochemistry,  77  ((1)): (213-216).  [PMID:23291751]
13. A A Kamboh,W-Y Zhu.  (2013-01-10)  Effect of increasing levels of bioflavonoids in broiler feed on plasma anti-oxidative potential, lipid metabolites, and fatty acid composition of meat..  Poultry science,  92  ((2)): (454-461).  [PMID:23300313]
14. Elaheh Kashani-Amin,Bagher Larijani,Azadeh Ebrahim-Habibi.  (2013-02-05)  Neohesperidin dihydrochalcone: presentation of a small molecule activator of mammalian alpha-amylase as an allosteric effector..  FEBS letters,  587  ((6)): (652-658).  [PMID:23376024]
15. Gowrikumar Saiprasad,Palanivel Chitra,Ramar Manikandan,Ganapasam Sudhandiran.  (2013-02-05)  Hesperidin alleviates oxidative stress and downregulates the expressions of proliferative and inflammatory markers in azoxymethane-induced experimental colon carcinogenesis in mice..  Inflammation research : official journal of the European Histamine Research Society ... [et al.],  62  ((4)): (425-440).  [PMID:23377175]
16. Asghar A Kamboh,Wei-Yun Zhu.  (2013-04-23)  Individual and combined effects of genistein and hesperidin supplementation on meat quality in meat-type broiler chickens..  Journal of the science of food and agriculture,  93  ((13)): (3362-3367).  [PMID:23605817]
17. G Allam,A S A Abuelsaad.  (2013-05-10)  In vitro and in vivo effects of hesperidin treatment on adult worms of Schistosoma mansoni..  Journal of helminthology,  88  ((3)): (362-370).  [PMID:23656891]
18. V Sridhar,M Surya Sandeep,P Ravindra Babu,K Naveen Babu.  (2013-07-25)  Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using felodipine and hesperetin in combination in Wistar rats and everted rat gut sacs in vitro..  Phytotherapy research : PTR,  28  ((5)): (699-705).  [PMID:23881850]
19. Vesna Kuntić,Jasmina Brborić,Ivanka Holclajtner-Antunović,Snezana Uskoković-Marković.  (2014-02-13)  Evaluating the bioactive effects of flavonoid hesperidin--a new literature data survey..  Vojnosanitetski pregled,  71  ((1)): (60-65).  [PMID:24516992]
20. Marisol Minig,Laura S Mazzaferro,Agostina Capecce,Javier D Breccia.  (2014-04-05)  Polyethyleneimine coating of magnetic particles increased the stability of an immobilized diglycosidase..  Biotechnology and applied biochemistry,  62  ((1)): (94-100).  [PMID:24698389]
21. Sophie Dufay,Alan Worsley,Aymeric Monteillier,Charlotte Avanzi,Jaclyn Sy,Ting Fat Ng,Jean-Michel Garcia,Man-Fai Lam,Paul Vanhoutte,Ian C K Wong.  (2014-05-16)  Herbal tea extracts inhibit Cytochrome P450 3A4 in vitro..  The Journal of pharmacy and pharmacology,  66  ((10)): (1478-1490).  [PMID:24824478]
22. Wanpeng Xi,Bo Fang,Qiyang Zhao,Bining Jiao,Zhiqin Zhou.  (2014-05-20)  Flavonoid composition and antioxidant activities of Chinese local pummelo (Citrus grandis Osbeck.) varieties..  Food chemistry,  161  (230-238).  [PMID:24837945]
23. Partha Pratim Roy,Sarbani Dey Ray,Supratim Ray.  (2014-06-03)  Combined experimental and in silico approaches for exploring antiperoxidative potential of structurally diverse classes of antioxidants on docetaxel-induced lipid peroxidation using 4-HNE as the model marker..  Bioorganic chemistry,  56  (1-7).  [PMID:24887149]
24. Su-Chen Ho,Chun-Ting Kuo.  (2014-06-24)  Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium)..  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,  71  (176-182).  [PMID:24955543]
25. Maryam Hamzeh-Mivehroud,Seifullah Rahmani,Mohammad-Ali Hosseinpour Feizi,Siavoush Dastmalchi,Mohammad-Reza Rashidi.  (2014-06-24)  In vitro and in silico studies to explore structural features of flavonoids for aldehyde oxidase inhibition..  Archiv der Pharmazie,  347  ((10)): (738-747).  [PMID:24956178]
26. Gowrikumar Saiprasad,Palanivel Chitra,Ramar Manikandan,Ganapasam Sudhandiran.  (2014-07-23)  Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis..  European journal of cancer (Oxford, England : 1990),  50  ((14)): (2489-2507).  [PMID:25047426]
27. Otilia J F Banji,David Banji,Kalpana Ch.  (2014-09-15)  Curcumin and hesperidin improve cognition by suppressing mitochondrial dysfunction and apoptosis induced by D-galactose in rat brain..  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,  74  (51-59).  [PMID:25217884]
28. John T Barr,Jeffrey P Jones,Nicholas H Oberlies,Mary F Paine.  (2014-10-19)  Inhibition of human aldehyde oxidase activity by diet-derived constituents: structural influence, enzyme-ligand interactions, and clinical relevance..  Drug metabolism and disposition: the biological fate of chemicals,  43  ((1)): (34-41).  [PMID:25326286]
29. Meryem Boukroufa,Chahrazed Boutekedjiret,Loïc Petigny,Njara Rakotomanomana,Farid Chemat.  (2014-12-02)  Bio-refinery of orange peels waste: a new concept based on integrated green and solvent free extraction processes using ultrasound and microwave techniques to obtain essential oil, polyphenols and pectin..  Ultrasonics sonochemistry,  24  (72-79).  [PMID:25435398]
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