潮霉素 B 来源于吸水链霉菌

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级别和纯度:

powder

CAS编号: 31282-04-9
分子式: C₂₀H₃₇N₃O₁₃
分子量: 527.52
PubChem编号: 23777801
PubChem SID: 504769727

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货号 (SKU)	包装规格	是否现货
H432610-50mg	50mg	现货
H432610-250mg	250mg	现货
H432610-1g	1g	现货
H432610-5g	5g	现货

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Anti-infection (2804) Antibiotic (2632) Bacterial (5911) Fungal (1689) Parasite (1836)

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基本描述

英文别名	SMP1_000163 \| BCBcMAP01_000235 \| O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-beta-D-talopyranosyl(1-5)-2-deoxy-N3-methyl-D-streptamine \| Hygromycin B, from Streptomyces hygroscopicus \| GS-5543 \| (2S,3R,3A'S,4S,4'S,5R,6R,6'R,7'S,7a'
规格或纯度	BioReagent, 用于细胞培养, 用于昆虫细胞培养, powder
英文名称	Hygromycin B from Streptomyces hygroscopicus
生化机理	作用方式：本品通过诱导原核生物中m-RNA模板的误读，抑制蛋白质合成，具有抑制翻译的作用。抗菌谱：潮霉素B对细菌、真菌和高等真核细胞有抑制作用。
储存温度	2-8°C储存
运输条件	冰袋运输
备注	注意: 潮霉素B产品应在Store at 2-8°C的温度下保存，其干燥固定形式可在Store at 2-8°C的温度下保存至少五年。其在37°C下可稳定30天。（对于溶液）如果在Store at 2-8°C下保存，该溶液可在两年内保持稳定。
产品介绍	化学结构：氨基糖苷类氨基糖苷是靶向核糖体的最广泛使用的一类抗生素。潮霉素B是一种氨基环醇抗生素。吸水链霉菌具有磷酸转移酶（HPH）活性，可将潮霉素B磷酸化，从而有助于激活针对该药物毒性作用的自身免疫。应用潮霉素B是一种氨基糖苷类抗生素，分离子从吸水链霉菌。它已被用于研究70S核糖体易位和mRNA模板误读水平的蛋白质合成；作为一种抗病毒剂，通过选择性穿透被病毒感染渗透的细胞并抑制翻译；以及作为潮霉素抗性基因转化细胞的选择剂。建议以100-800 μg/mL的浓度用作选择剂，其中对于原核生物使用100 μg/mL，对于低等真核生物使用200 μg/mL，对于高等真核生物使用150-400 μg/mL。潮霉素B抗生素可用于以下细胞的抗潮性作用： 160 μg/ml，用于经质粒混合物转染的293T细胞。 150 g/ml，用于MCF-7 ALOX12 细胞。 MSCV荧光素酶PGK-hygro质粒。 STAT3报告基因HeLa稳定细胞系（通过受STAT3启动子控制的荧光素酶基因稳定转染），维持在补充有10％FBS的DMEM中。制备说明该产物通过离子交换色谱法进行纯化。潮霉素B可以>50 mg/mL的浓度溶于水，也可溶于甲醇或乙醇。溶液应通过过滤而非高压灭菌进行灭菌。另外，据报道潮霉素B溶液在冷冻时会失去活性，并且其在冷藏可保持稳定，因此应避免冷冻。 Chemical structure: aminoglycoside Aminoglycosides are the most widely used class of antibiotics that target ribosome. Hygromycin B is an aminocyclitol antibiotic. The organism, S. hygroscopicus contains phosphotransferase (HPH) activity, which phosphorylates hygromycin B helping in autoimmunity against the toxic effects of the drug. Application Hygromycin B antibiotic was used for hygro resistance effect in the following cells: transfected 293T cells with mixture of plasmids at 160 μg/ml. MCF-7 ALOX12 cells at 150 μg/ml. MSCV Luciferase PGK-hygro plasmid. STAT3 Reporter HeLa Stable Cell Line (stably transfected with Luciferase gene under the control of STAT3 promoter) maintained in DMEM supplemented with 10% FBS. Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It has been used to study protein synthesis at the level of the 70S ribosome translocation and mRNA template misreading, as an antiviral agent by selectively penetrating cells rendered permeable by virus infection and inhibiting translation, and as a selection agent for hygromycin resistance gene transformed cells. It is recommended for use as a selection agent at 100-800 μg/mL, specifically at 100 μg/mL for prokaryotes, 200 μg/mL for lower eukaryotes and 150-400 μg/mL for higher eukaryotes.

关联靶点（其它种属）

Saccharomyces cerevisiae (19171 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Ustilago maydis (75 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Candida albicans (78123 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	504769727
分子类型	小分子
IIUPAC Name	(2S,3'R,3aS,4S,4'S,5'R,6R,6'R,7S,7aS)-4-[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6'-[(1R)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol
INCHI	1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1
InChi Key	GRRNUXAQVGOGFE-XKIAHZFYSA-N
Smiles	CNC1CC(C(C(C1O)OC2C3C(C(C(O2)CO)O)OC4(O3)C(C(C(C(O4)C(CO)N)O)O)O)O)N
Isomeric SMILES	CN[C@H]1C[C@H]([C@@H]([C@H]([C@@H]1O)O[C@H]2[C@@H]3[C@H]([C@H]([C@H](O2)CO)O)O[C@]4(O3)[C@@H]([C@H]([C@H]([C@H](O4)[C@@H](CO)N)O)O)O)O)N
UN Number	3462
Packing Group	I
分子量	527.52
Reaxy-Rn	1335986
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1335986&ln=

化学和物理性质

溶解性	H2O：50mg/mL（作为储备溶液。储备溶液应储存在 Store at 2-8°C。在 37°C 下可稳定保存 30 天。）
比旋光度	20° (C=1,H2O)
熔点	160-180°C
分子量	527.500 g/mol
XLogP3	-6.600
氢键供体数Hydrogen Bond Donor Count	11
氢键受体数Hydrogen Bond Acceptor Count	16
可旋转键计数Rotatable Bond Count	6
精确质量Exact Mass	527.233 Da
单同位素质量Monoisotopic Mass	527.233 Da
拓扑极表面积Topological Polar Surface Area	272.000 Å²
重原子数Heavy Atom Count	36
形式电荷Formal Charge	0
复杂度Complexity	756.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	16
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS05, GHS06, GHS08
信号词	危险
危险声明	H318: 造成严重的眼睛损伤 H332: 吸入有害 H300+H310+H330: 吞咽，皮肤接触或吸入会致命。
预防措施声明	P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P262: 不要进入眼睛、皮肤或衣服。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P284: 如果通风不良，请佩戴呼吸防护装置。 P320: 迫切需要特殊治疗（请参阅此标签上的...）。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P361+P364: 立即脱掉所有沾染的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P305+P354+P338: 如果进入眼睛：立即用水冲洗几分钟。取下隐形眼镜（如果有的话），并且操作简单。继续冲洗。 P317: 寻求紧急医疗救助。 P316: 立即寻求紧急医疗救助。 P342+P316: 如果出现呼吸道症状：立即寻求急救。
Class	6.1
Merck Index	4852

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批号(Lot Number)	证书类型	货号
G2315534	分析证书	H432610
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抗生素阻断细菌蛋白合成

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