| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| H432270-1ml |
1ml |
期货  |
|
| 英文别名 | 25-Hydroxyvitamin D3 monohydrate, >=99.0% (HPLC) | Cholecalciferol, 25-hydroxy- | 3-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANOL | Calcifediol | HMS1791G13 | BDBM50521013 | 1H-Indene-1-pent |
|---|---|
| 规格或纯度 | Moligand™, ≥99 atom% 13C,≥95%, 100 μg/mL in ethanol |
| 英文名称 | 25-Hydroxyvitamin D₃-23,24,25,26,27-¹³C₅ solution |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
25羟维生素D 3 (骨化二醇）是一种激素原，通过维生素 D 3 (胆钙化醇）的羟基化作用在肝脏内产生。它是合成骨化三醇{1,25-二羟维生素 D 3 或称 [1,25(OH) 2 D 3 ]}的前体。它可用作生物标记物，用于确定体内维生素D的状态。 25-羟维生素D 3 -23,24,25,26,27- 13 C 5 是维生素 D 3 的同位素，其中的 C-23、C-24、C-25、 C-26和 C-27碳原子由 13 C 6 同位素所 应用 25羟维生素D 3 -23,24,25,26,27- 13 C 5 可用作稳定的同位素内标物，用于通过质谱得到特定生物样品的准确数据。 25-Hydroxyvitamin D 3 (calcifediol) is a prohormone produced via hydroxylation of vitamin D 3 (cholecalciferol) in the liver. It is a precursor for the synthesis of calcitriol {1,25-dihydroxyvitamin D 3 or [1,25(OH) 2 D 3 ]}. It is used as a biomarker to determine the status of vitamin D in the body. 25-Hydroxyvitamin D 3 -23,24,25,26,27- 13 C 5 is an isotope of vitamin D 3 wherein C-23, C-24, C-25, C-26, C-27 carbons are replaced by 13 C 6 isotope. Application 25-Hydroxyvitamin D 3 -23,24,25,26,27- 13 C 5 can be used as a stable isotope internal standard for data interpretation in specific biological samples by mass spectrometry. |
| 纯度 | ≥99 atom% 13C,≥95% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol |
| INCHI | 1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1 |
| InChi Key | JWUBBDSIWDLEOM-DTOXIADCSA-N |
| Smiles | CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C |
| Isomeric SMILES | C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](CCC3=C)O)C |
| 关联CAS | 63283-36-3 |
| 分子量 | 400.64 |
| Reaxy-Rn | 34003584 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=34003584&ln= |
| 分子量 | 400.600 g/mol |
|---|---|
| XLogP3 | 6.200 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 2 |
| 可旋转键计数Rotatable Bond Count | 6 |
| 精确质量Exact Mass | 400.334 Da |
| 单同位素质量Monoisotopic Mass | 400.334 Da |
| 拓扑极表面积Topological Polar Surface Area | 40.500 Ų |
| 重原子数Heavy Atom Count | 29 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 655.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 5 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 2 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 2 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 1. He Qiting, Qin Ruixi, Glowacki Julie, Zhou Shuanhu, Shi Jie, Wang Shaoyi, Gao Yuan, Cheng Lei. (2021) Synergistic stimulation of osteoblast differentiation of rat mesenchymal stem cells by leptin and 25(OH)D3 is mediated by inhibition of chaperone-mediated autophagy. Stem Cell Research & Therapy, 12 (1): (1-13). [PMID:34717752] [10.1186/s13287-021-02623-z] |
| 2. Chen Huaiyi, Liao Ziwei, Sun Gongwei, Wu Tianhao, Yang Jinlei, Pan Siyuan, Zhang Sichun, Tang Fei. (2025) Affinity Capture Coupled with Nano-Electrospray Ionization-Mass Spectrometry for Rapid Detection of 25-hydroxyvitamin D3 in Serum. Journal of Analysis and Testing, (1-5). [10.1007/s41664-025-00361-2] |
| 3. Cai Tongji, Chen Meilun, Yang Jie, Tang Chunhua, Lu Xiaoling, Wei Zheng, Jiang Hanbing, Hou Yucui, Zhao Jia, Yu Peng. (2024) An AuNPs-based electrochemical aptasensor for the detection of 25-hydroxy vitamin D3. ANALYTICAL SCIENCES, (1-9). [PMID:38190076] [10.1007/s44211-023-00489-0] |
| 4. Lixin Kang, Haoran Li, Kexin Lin, Shen Hu, Song Liu, Yuben Qiao, Ying Wang, Aitao Li. (2025) Regioselectivity Switching in CYP107Pdh-Catalyzed VD3 Hydroxylation: A Structure-Guided Approach To Improve Calcidiol Production. ACS Catalysis, 15 (5): (4160-4171). [10.1021/acscatal.5c00444] |
| 5. Zi-qing Wang, Li-ping Hao, Zi-xuan Meng, Hao-ran Zhang, Wei-jun Kang, Lian-feng Ai. (2025) Simultaneous determination of 25(OH)D2, 25(OH)D3 and 1α,25(OH)2D3 in human serum by derivatization-liquid chromatography-tandem mass spectrometry. ANALYTICAL BIOCHEMISTRY, 701 (115821). [PMID:40010585] [10.1016/j.ab.2025.115821] |
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