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Hederagenin
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| H424095-1ml |
1ml |
现货  |
|
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基本描述
| 别名 | 常春藤皂甙元 | 常春藤皂苷 |
|---|---|
| 英文别名 | Olean-12-en-28-oic acid, 3.beta.,23-dihydroxy- | AKOS016036289 | BDBM50442880 | CCG-269472 | (3-beta,4-alpha)-3,23-Dihydroxyolean-12-en-28-oic acid | (4AS,6AS,6BR,8AR,9R,10S,12AR,12BR,14BS)-10-HYDROXY-9-(HYDROXYMETHYL)-2,2,6A,6B,9,12A-HEXAMETHYL-1,2,3,4,4 |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Hederagenin |
| 生化机理 | 皂甙。抗炎。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 产品介绍 |
Hederagenin是三萜皂苷，能够抑制细胞中由于LPS刺激引起的 iNOS, COX-2,和 NF-κB的表达。 Hederagenin (3,23-Dihydroxyolean-12-en-28-acid), a triterpenoid saponin, is used to study the properties of triterpenoid saponins as biopesticides that prevent fungal growth, bacterial growth, and viral plant diseases. Hederagenin may be used as a reference in assays to detect it in biological fluids. |
关联靶点（人）
SLCO1B3
Tchem
溶质载体有机阴离子转运蛋白家族成员1B3(Solute carrier organic anion transporter family member 1B3)
(2 活性数据)
F3
Tclin
组织因子(Tissue factor)
(1 活性数据)
EGFR
Tclin
Epidermal growth factor receptor erbB1
(33727 活性数据)
ALOX5
Tclin
Arachidonate 5-lipoxygenase
(6568 活性数据)
PTGS1
Tclin
Cyclooxygenase-1
(9233 活性数据)
PTGS2
Tclin
Cyclooxygenase-2
(13999 活性数据)
ALOX15B
Tchem
Arachidonate 15-lipoxygenase, type II
(7244 活性数据)
NQO1
Tchem
Quinone reductase 1
(1746 活性数据)
A-375
(9258 活性数据)
AGS
(1999 活性数据)
BGC-823
(3035 活性数据)
DLD-1
(17511 活性数据)
HL-60
(67320 活性数据)
HT-29
(80576 活性数据)
M14
(47487 活性数据)
MCF7
(126967 活性数据)
NCI-H1975
(4994 活性数据)
MKN-45
(2102 活性数据)
SW-1736
(356 活性数据)
A549
(127892 活性数据)
FaDu
(1726 活性数据)
HepG2
(196354 活性数据)
A2780
(11979 活性数据)
KB
(17409 活性数据)
HeLa
(62764 活性数据)
MDA-MB-231
(73002 活性数据)
8505C
(583 活性数据)
SLCO1B1
Tchem
Solute carrier organic anion transporter family member 1B1
(2672 活性数据)
SLCO1B3
Tchem
Solute carrier organic anion transporter family member 1B3
(2517 活性数据)
PRKAA2
Tchem
AMP-activated protein kinase, AMPK
(12273 活性数据)
USP7
Tchem
Ubiquitin carboxyl-terminal hydrolase 7
(837 活性数据)
NCI-H187
(598 活性数据)
L02
(4864 活性数据)
关联靶点（其它种属）
Coagulation factor III (5 活性数据)
Abcb1b
P-glycoprotein 1 (174 活性数据)
Leishmania infantum (5912 活性数据)
Carassius auratus (65 活性数据)
Hepatitis C virus (23859 活性数据)
NIH3T3 (5395 活性数据)
Oreochromis (28 活性数据)
Pomacea canaliculata (20 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (4aS,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-10-hydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid |
| INCHI | 1S/C30H48O4/c1-25(2)13-15-30(24(33)34)16-14-28(5)19(20(30)17-25)7-8-22-26(3)11-10-23(32)27(4,18-31)21(26)9-12-29(22,28)6/h7,20-23,31-32H,8-18H2,1-6H3,(H,33,34)/t20-,21+,22+,23-,26-,27-,28+,29+,30-/m0/s1 |
| InChi Key | PGOYMURMZNDHNS-MYPRUECHSA-N |
| Smiles | CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)CO)O)C)C)C2C1)C)C(=O)O)C |
| Isomeric SMILES | C[C@]12CC[C@@H]([C@@]([C@@H]1CC[C@@]3([C@@H]2CC=C4[C@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)O)C)C)(C)CO)O |
| 分子量 | 472.7 |
| Reaxy-Rn | 2026440 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2026440&ln= |
化学和物理性质
| 分子量 | 472.700 g/mol |
|---|---|
| XLogP3 | 6.800 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 2 |
| 精确质量Exact Mass | 472.355 Da |
| 单同位素质量Monoisotopic Mass | 472.355 Da |
| 拓扑极表面积Topological Polar Surface Area | 77.800 Ų |
| 重原子数Heavy Atom Count | 34 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 907.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 9 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
| 信号词 | 警告 |
|---|---|
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 |
| WGK Germany | 3 |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
引用文献
| 1. Li Pengfei, Peng Jun, Li Yuexin, Gong Lili, Lv Yali, Liu He, Zhang Tianhong, Yang Song, Liu Hongchuan, Li Jinglai, Liu Lihong. (2021) Pharmacokinetics, Bioavailability, Excretion and Metabolism Studies of Akebia Saponin D in Rats: Causes of the Ultra-Low Oral Bioavailability and Metabolic Pathway. Frontiers in Pharmacology, 12 [PMID:33935711] [10.3389/fphar.2021.621003] |
| 2. Junyan Wang, Minmin Huang, Haihong Hu, Lushan Yu, Su Zeng. (2014) Pregnane X receptor-mediated transcriptional activation of UDP-glucuronosyltransferase 1A1 by natural constituents from foods and herbs. FOOD CHEMISTRY, 164 (74). [PMID:24996308] [10.1016/j.foodchem.2014.05.004] |