| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| H423959-1ml |
1ml |
现货  |
|
| 别名 | 5-羟基色氨酸(5-HTP) | 5-羟基-L-色氨酸 | L -2-氨基-3-(5-羟基吲哚基)丙酸 | L-5-羟色氨酸 |
|---|---|
| 英文别名 | (2S)-2-amino-3-(5-hydroxyindol-3-yl)propanoic acid | bmse000457 | NCGC00091062-03 | NCGC00091062-04 | Oxitriptanum [INN-Latin] | 5-Hydroxy-L-tryptophan, powder | CHEBI:17780 | DB02959 | 5HTP | Cincofarm | n-(tert-butoxycarbonyl)-3-piperidinone | Tox21_111 |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | 5-Hydroxy-L-tryptophan |
| 生化机理 | 血清素的直接前体； L -芳香族氨基酸脱羧酶底物。血清素前体。在体内诱导5-羟色胺的作用。增强抗抑郁作用。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 质子偶联氨基酸转运体 1 抑制剂；质子偶联氨基酸转运体 2 抑制剂 |
| 产品介绍 |
易溶于水。气微、味略带咸涩. 5-Hydroxy-L-tryptophan has been used: · to inject experimental mice for serotonin detection · as a precursor of 5-hydroxytryptamine and injected in pregnant mice and neonatal rats for vital neutral red staining of lung slices · as a standard in citrate-acetate buffer for its use in high performance liquid chromatography (HPLC) analysis 5-Hydroxy-L-tryptophan has been used: · to inject experimental mice for serotonin detection · as a precursor of 5-hydroxytryptamine and injected in pregnant mice and neonatal rats for vital neutral red staining of lung slices · as a standard in citrate-acetate buffer for its use in high performance liquid chromatography (HPLC) analysis |
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 224-411-1 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | (2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid |
| INCHI | 1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 |
| InChi Key | LDCYZAJDBXYCGN-VIFPVBQESA-N |
| Smiles | C1=CC2=C(C=C1O)C(=CN2)CC(C(=O)O)N |
| Isomeric SMILES | C1=CC2=C(C=C1O)C(=CN2)C[C@@H](C(=O)O)N |
| UN Number | 2811 |
| Packing Group | I |
| 分子量 | 220.22 |
| Beilstein号 | 88200 |
| Reaxy-Rn | 88199 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=88199&ln= |
| 折光率 | 1.4850 |
|---|---|
| 比旋光度 | -33 ° (C=1, H2O) |
| 熔点 | 270°C |
| 分子量 | 220.220 g/mol |
| XLogP3 | -1.200 |
| 氢键供体数Hydrogen Bond Donor Count | 4 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 3 |
| 精确质量Exact Mass | 220.085 Da |
| 单同位素质量Monoisotopic Mass | 220.085 Da |
| 拓扑极表面积Topological Polar Surface Area | 99.300 Ų |
| 重原子数Heavy Atom Count | 16 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 272.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 1 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS06 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H226: 易燃液体和蒸气 H302: 吞食有害 H319: 引起严重眼睛刺激 H332: 吸入有害 |
| 预防措施声明 |
P210: 远离热源，热表面，火花，明火和其他点火源。 - 禁止抽烟。 P233: 保持容器密闭。 P240: 地面/粘结容器和接收设备 P241: 使用防爆的[电气/通风/照明/.../]设备。 P242: 仅使用无火花的工具。 P243: 采取防静电措施 P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P330: 漱口 P303+P361+P353: 如皮肤（或头发）沾染：立即脱掉所有沾染的衣服。用水清洗皮肤/淋浴。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P370+P378: 火灾时：使用干砂、干粉或抗醇泡沫灭火。 P403+P235: 存放在通风良好的地方。保持低温。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P317: 寻求紧急医疗救助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | YN7110000 |
| Class | 6.1 |
| Merck Index | 4847 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Faceshields,Gloves |
| 1. Jin Yuan Zhang, Ying Zhang, Yu Zou, Ze Li Bo Xu, Bo Zhang, Wang Ren. (2024) Physicochemically modulated fluorescence-scattering ratiometric sensor for selective and visual detection of levodopa. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 308 (123746). [PMID:38091648] [10.1016/j.saa.2023.123746] |
| 2. Shikai Zhang, Qing Xu, Changbo Ji, Xiaoyu Han, Yang Zhou, Chao Liang, Linran Ma, Weijian Sun, Yanling Li, Zhengyou Yang, Fengchun Zhao, Yuan Tian. (2023) Study on secondary metabolites of endophytic fungus Diaporthe sp. AC1 induced by tryptophan analogs. Frontiers in Microbiology, 14 (1254609). [PMID:37876783] [10.3389/fmicb.2023.1254609] |
| 3. Yan Wang, Bin Peng, Yuanyuan Gong, Yingrong Xie, Tingting Feng, Xiaolin Liu, Bowei Chen, Yong Zhang. (2023) Carboxyl and amino acid functionalized indole-based polymer for ultrafast uranium extraction in aqueous solution. JOURNAL OF MOLECULAR LIQUIDS, 383 (122143). [10.1016/j.molliq.2023.122143] |
| 4. Qixing Nie, Yonggan Sun, Mingzhi Li, Sheng Zuo, Chunhua Chen, Qiongni Lin, Shaoping Nie. (2023) Targeted modification of gut microbiota and related metabolites via dietary fiber. CARBOHYDRATE POLYMERS, 316 (120986). [PMID:37321707] [10.1016/j.carbpol.2023.120986] |
| 5. Ya-Qian Wang, Li Li, Jin Yin, Xu Yu, Xiaowei Wu, Li Xu. (2023) Turn on fluorescence detection of curcumin in food matrices by the novel fluorescence sensitizer. ANALYTICA CHIMICA ACTA, 1254 (341094). [PMID:37005020] [10.1016/j.aca.2023.341094] |
| 6. Feifei Song, Tao Gu, Lin Zhang, Jiaxing Zhang, Shengping You, Wei Qi, Rongxin Su. (2023) Rational design of tryptophan hydroxylation 1 for improving 5-Hydroxytryptophan production. ENZYME AND MICROBIAL TECHNOLOGY, 165 (110198). [PMID:36736156] [10.1016/j.enzmictec.2023.110198] |
| 7. Qiuyang Huang, Xiaoling Zang, Zhiwei Zhang, Hang Yu, Baoyan Ding, Zhuangzhuang Li, Simin Cheng, Xin Zhang, Mustafa R.K. Ali, Xue Qiu, Zhihua Lv. (2023) Study on endogenous inhibitors against PD-L1: cAMP as a potential candidate. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 230 (123266). [PMID:36646351] [10.1016/j.ijbiomac.2023.123266] |
| 8. Zhuangzhuang Li, Baoyan Ding, Mustafa R. K. Ali, Lizhen Zhao, Xiaoling Zang, Zhihua Lv. (2022) Dual Effect of Tryptamine on Prostate Cancer Cell Growth Regulation: A Pilot Study. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (19): (11087). [PMID:36232383] [10.3390/ijms231911087] |
| 9. Qiao Chong, Chen Fei, Liu Zhan, Huang Tianfang, Li Wei, Zhang Guolin, Luo Yinggang. (2022) Functional characterization of a catalytically promiscuous tryptophan decarboxylase from camptothecin-producing Camptotheca acuminata. Frontiers in Plant Science, 13 [PMID:36061783] [10.3389/fpls.2022.987348] |
| 10. Wu Lijuan, Ran Lisha, Wu Yazeng, Liang Manyu, Zeng Jing, Ke Famin, Wang Fang, Yang Jian, Lao Xiaoqing, Liu Li, Wang Qin, Gao Xiaowei. (2022) Oral Administration of 5-Hydroxytryptophan Restores Gut Microbiota Dysbiosis in a Mouse Model of Depression. Frontiers in Microbiology, 13 [PMID:35572711] [10.3389/fmicb.2022.864571] |
| 11. Wang Yan, Liu Xiaolin, Xie Yingrong, Chen Bowei, Zhang Yong. (2022) Effective and rapid adsorption of uranium via synergy of complexation and cation-π interaction. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 331 (2): (1115-1126). [10.1007/s10967-021-08179-9] |
| 12. Zhang Yanfeng, He Yongzhi, Zhang Nan, Gan JiaJia, Zhang Shan, Dong Zhiyang. (2021) Combining protein and metabolic engineering strategies for biosynthesis of melatonin in Escherichia coli. Microbial Cell Factories, 20 (1): (1-13). [PMID:34454478] [10.1186/s12934-021-01662-8] |
| 13. Xu Da, Fang Mengjun, Wang Haijiao, Huang Lei, Xu Qinyang, Xu Zhinan. (2020) Enhanced production of 5-hydroxytryptophan through the regulation of L-tryptophan biosynthetic pathway. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 104 (6): (2481-2488). [PMID:32006050] [10.1007/s00253-020-10371-y] |
| 14. Qing Wang, Yao Long, Lin Yao, Li Xu, Zhi-Guo Shi, Lanying Xu. (2016) Preparation, characterization and application of a reversed phase liquid chromatography/hydrophilic interaction chromatography mixed-mode C18-DTT stationary phase. TALANTA, 146 (442). [PMID:26695288] [10.1016/j.talanta.2015.09.009] |
| 15. Ai Yulin, Huang Yusong, Zhao Hongru, Su Bingmei, Lin Juan. (2025) Engineered phenylalanine hydroxylase coupled with an effective cofactor synthesis and regeneration system for high-yield production of 5-hydroxytryptophan. Bioresources and Bioprocessing, 12 (1): (1-14). [PMID:40047997] [10.1186/s40643-025-00846-z] |
| 16. Chenjie Yang, Hailong Yu, Weihong Li, Hairu Lin, Hao Wu, Chunhui Deng. (2024) High-Throughput Metabolic Pattern Screening Strategy for Early Colorectal and Gastric Cancers Based on Covalent Organic Frameworks-Assisted Laser Desorption/Ionization Mass Spectrometry. ANALYTICAL CHEMISTRY, 96 (16): (6264-6274). [PMID:38600676] [10.1021/acs.analchem.3c05527] |
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