| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| H275441-500μg |
500μg |
期货  |
|
| 英文别名 | 4GUY9L896T | MLS002701927 | HMS1989B14 | HY-119970 | NCGC00163416-02 | 4-18-00-01434 (Beilstein Handbook Reference) | (3aS)-3,3aalpha,4alpha,4a,7aalpha,8,9,9aalpha-octahydro-4-hydroxy-4abeta,8alpha-dimethyl-3-methyleneazuleno(6,5-b)-furan-2,5-dione | (3aS |
|---|---|
| 英文名称 | Helenalin |
| 生化机理 | NF-κB抑制剂。诱导细胞凋亡。显示抗炎和抗肿瘤作用。在体内显示出肝脏保护作用。口服有效。 |
| 储存温度 | -20°C储存,干燥 |
| 运输条件 | 超低温冰袋运输 |
| 备注 | 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有关更多信息，请参考SDS。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| 产品介绍 |
储存在-20℃。存放在干燥的条件下。该产品最多可存储12个月。 Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (3aR,5R,5aR,8aR,9S,9aS)-9-hydroxy-5,8a-dimethyl-1-methylidene-3a,4,5,5a,9,9a-hexahydroazuleno[6,7-b]furan-2,8-dione |
| INCHI | 1S/C15H18O4/c1-7-6-10-12(8(2)14(18)19-10)13(17)15(3)9(7)4-5-11(15)16/h4-5,7,9-10,12-13,17H,2,6H2,1,3H3/t7-,9+,10-,12-,13+,15+/m1/s1 |
| InChi Key | ZVLOPMNVFLSSAA-XEPQRQSNSA-N |
| Smiles | CC1CC2C(C(C3(C1C=CC3=O)C)O)C(=C)C(=O)O2 |
| Isomeric SMILES | C[C@@H]1C[C@@H]2[C@H]([C@@H]([C@]3([C@H]1C=CC3=O)C)O)C(=C)C(=O)O2 |
| 分子量 | 262.3 |
| Reaxy-Rn | 1291183 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1291183&ln= |
| 溶解性 | Soluble in ethanol\xa0(up to 10 mg/ml) and in DMSO\xa0(up to 20 mg/ml). |
|---|---|
| 分子量 | 262.300 g/mol |
| XLogP3 | 1.400 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 0 |
| 精确质量Exact Mass | 262.121 Da |
| 单同位素质量Monoisotopic Mass | 262.121 Da |
| 拓扑极表面积Topological Polar Surface Area | 63.600 Ų |
| 重原子数Heavy Atom Count | 19 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 506.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 6 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 |
|---|
| 1. Honda S et al.. (2021) Cellular senescence promotes endothelial activation through epigenetic alteration, and consequently accelerates atherosclerosis.. Sci Rep, 11 (14608). [PMID:34272458] |
| 2. Sun YZ et al.. (2018) DNAJA4 deficiency enhances NF-kappa B-related growth arrest induced by hyperthermia in human keratinocytes.. J Dermatol Sci, [PMID:29807809] |
| 3. Zhang YJ et al.. (2019) Extracellular vesicles derived from Malassezia furfur stimulate IL-6 production in keratinocytes as demonstrated in in vitro and in vivo models.. J Dermatol Sci, 93 (3): (168-175). [PMID:30904352] |
| 4. Suzuki M et al.. (2020) Hyaluronan suppresses enhanced cathepsin K expression via activation of NF-?B with mechanical stress loading in a human chondrocytic HCS-2/8 cells.. Sci Rep, 10 (216). [PMID:31937805] |
| 5. Li Y et al.. (2021) Tumor-associated macrophages (TAMs)-derived osteopontin (OPN) upregulates PD-L1 expression and predicts poor prognosis in non-small cell lung cancer (NSCLC).. Thorac Cancer, 12 (20): (2698-2709). [PMID:34423566] |
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