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5-羟基黄酮

2篇引用文献 COA COA
    级别和纯度:
  • ≥98%(HPLC)
有货

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货号 (SKU) 包装规格 是否现货 价格 数量
H157353-50mg
 50mg 现货 Stock Image
H157353-100mg
 100mg 现货 Stock Image
H157353-250mg
 250mg 现货 Stock Image
H157353-500mg
 500mg 现货 Stock Image
H157353-1g
 1g 现货 Stock Image
H157353-5g
 5g 现货 Stock Image
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六元杂环化合物 (1701) 苯丙素类 (153)
main product photo

基本描述

别名 5-羟基黄酮 | 羟基苯基苯并吡喃酮 NSC 26745
英文别名 BDBM50049385 | 378AE9MHL3 | NCGC00095329-02 | SR-05000002480 | Q63408974 | NCGC00095329-03 | MFCD00016944 | NSC26745 | NSC-26745 | MLS002639146 | SR-05000002480-1 | BRD-K08048246-001-01-8 | FLAVONE, 5-HYDROXY- | AKOS015856472 | NCGC00095329-01 | LMPK12110
规格或纯度 ≥98%(HPLC)
英文名称 5-Hydroxyflavone
运输条件 常规运输
产品介绍

Reactant involved in: · Condensation reactions for synthesis of copper(II) complexes as bioactive molecules to combat antioxidants · Thermal behavior studies of vanadyl complexes with flavone derivatives in terms of insulin-mimetic agents · O-methylation with di-Me carbonate · DFT studies on excited-state intramolecular proton transfer
纯度 ≥98%(HPLC)

关联靶点（人）

CYP1A2 Tchem 细胞色素 P450 1A2(Cytochrome P450 1A2) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CYP1B1 Tchem 细胞色素 P450 1B1(Cytochrome P450 1B1) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
NR3C1 Tclin Glucocorticoid receptor (14987 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TOP2A Tclin DNA topoisomerase II alpha (6317 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AKR1B1 Tclin Aldose reductase (1404 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA2A Tclin Adenosine A2a receptor (16305 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP1B1 Tchem Cytochrome P450 1B1 (1148 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NEU2 Tbio Sialidase 2 (382 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GBA1 Tclin Beta-glucocerebrosidase (14647 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP1A1 Tchem Cytochrome P450 1A1 (1169 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FBP1 Tchem Fructose-1,6-bisphosphatase (1199 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FASN Tchem Fatty acid synthase (3390 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
K562 (73714 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MCF7 (126967 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HepG2 (196354 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KB (17409 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GNAS Tbio Guanine nucleotide-binding protein G(s), subunit alpha (103405 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
POLI Tchem DNA polymerase iota (116820 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AKR1B10 Tchem Aldo-keto reductase family 1 member B10 (300 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SMN1 Tchem Survival motor neuron protein (34246 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TARDBP Tchem TAR DNA-binding protein 43 (40113 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Pkm Pyruvate kinase isozymes M1/M2 (66 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Salmonella typhimurium (15756 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Trypanosoma brucei brucei (13300 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CCRF S-180 (1031 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Lewis lung carcinoma cell line (1243 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
fabG 3-oxoacyl-acyl-carrier protein reductase (70 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
fabI Enoyl-acyl-carrier protein reductase (415 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ntrk2 BDNF/NT-3 growth factors receptor (124 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Gabrp GABA-A receptor; anion channel (5731 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 488184085
EC号 207-743-1
分子类型 小分子
IIUPAC Name 5-hydroxy-2-phenylchromen-4-one
INCHI 1S/C15H10O3/c16-11-7-4-8-13-15(11)12(17)9-14(18-13)10-5-2-1-3-6-10/h1-9,16H
InChi Key IYBLVRRCNVHZQJ-UHFFFAOYSA-N
Smiles C1=CC=C(C=C1)C2=CC(=O)C3=C(C=CC=C3O2)O
Isomeric SMILES C1=CC=C(C=C1)C2=CC(=O)C3=C(C=CC=C3O2)O
分子量 238.24
Beilstein号 18(5)2,254
Reaxy-Rn 194429
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=194429&ln=

化学和物理性质

熔点 157-161℃
分子量 238.240 g/mol
XLogP3 2.500
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 3
可旋转键计数Rotatable Bond Count 1
精确质量Exact Mass 238.063 Da
单同位素质量Monoisotopic Mass 238.063 Da
拓扑极表面积Topological Polar Surface Area 46.500 Ų
重原子数Heavy Atom Count 18
形式电荷Formal Charge 0
复杂度Complexity 355.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 警告
危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激
预防措施声明

P264: 处理后要彻底洗手。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P321: 特殊处理（请参阅此标签上的...）。

P302+P352: 如皮肤沾染：用水充分清洗。

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。
WGK Germany 3
个人防护装备 Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到8个结果

批号(Lot Number) 证书类型 货号
K2110738 分析证书 H157353
F2129280 分析证书 H157353
B2209255 分析证书 H157353
B2209257 分析证书 H157353
B2209258 分析证书 H157353
B2209259 分析证书 H157353
B2209261 分析证书 H157353
B2209264 分析证书 H157353

此产品的引用文献

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引用文献

1. A R Ibrahim,Y J Abul-Hajj.  (1989-12-01)  Aromatic hydroxylation and sulfation of 5-hydroxyflavone by Streptomyces fulvissimus..  Applied and environmental microbiology,  55  ((12)): (3140-3142).  [PMID:2619306]
2. M Vietri,A Pietrabissa,R Spisni,F Mosca,G M Pacifici.  (2002-08-07)  7-OH-flavone is sulfated in the human liver and duodenum, whereas 5-OH-flavone and 3-OH-flavone are potent inhibitors of SULT1A1 activity and 7-OH-flavone sulfation rate..  Xenobiotica; the fate of foreign compounds in biological systems,  32  ((7)): (563-571).  [PMID:12162852]
3. Errol G Lewars,Raymond E March.  (2007-04-28)  Fragmentation of 3-hydroxyflavone; a computational and mass spectrometric study..  Rapid communications in mass spectrometry : RCM,  21  ((10)): (1669-1679).  [PMID:17465009]
4. R Sai Sathish,A Goutam Raju,G Nageswara Rao,C Janardhana.  (2007-05-29)  A fluorescent fluoride ion probe based on a self-organized ensemble of 5-hydroxyflavone-Al(III) complex..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  69  ((1)): (282-285).  [PMID:17531527]
5. Wimal Herath,Julie Rakel Mikell,Amber Lynn Hale,Daneel Ferreira,Ikhlas Ahmad Khan.  (2008-04-02)  Microbial metabolism part 9. Structure and antioxidant significance of the metabolites of 5,7-dihydroxyflavone (chrysin), and 5- and 6-hydroxyflavones..  Chemical & pharmaceutical bulletin,  56  ((4)): (418-422).  [PMID:18379084]
6. Sankarlal Ash,Sankar Prasad De,Santanu Pyne,Ajay Misra.  (2009-09-18)  Excited state intramolecular proton transfer in 3-hydroxy flavone and 5-hydroxy flavone: a DFT based comparative study..  Journal of molecular modeling,  16  ((5)): (831-839).  [PMID:19760438]
7. Juan José Baeza-Baeza,María Celia García-Álvarez-Coque.  (2014-06-20)  Some insights on the description of gradient elution in reversed-phase liquid chromatography..  Journal of separation science,  37  ((17)): (2269-2277).  [PMID:24945785]
8. David J Sukovich,Cyrus Modavi,Markus de Raad,Robin N Prince,J Christopher Anderson.  (2015-01-27)  DNA-Linked Enzyme-Coupled Assay for Probing Glucosyltransferase Specificity..  ACS synthetic biology,  4  ((7)): (833-841).  [PMID:25621860]
9. Ricardo Q Aucelio,Juliana M Carvalho,Juliana T Real,Luis Maqueira-Espinosa,Aurora Pérez-Gramatges,Andrea R da Silva.  (2016-04-24)  Study of the interaction of flavonoids with 3-mercaptopropionic acid modified CdTe quantum dots mediated by cetyltrimethyl ammonium bromide in aqueous medium..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  172  (147-155).  [PMID:27106812]
10. Ester Peris-García,Jorge Rodríguez-Martínez,Juan J Baeza-Baeza,María.  (2018-06-21)  Search of non-ionic surfactants suitable for micellar liquid chromatography..  Analytical and bioanalytical chemistry,  410  ((20)): (5043-5057).  [PMID:29922861]
11. Hui Cao,Xiaojuan Liu,Nataša Poklar Ulrih,Pradeep K Sengupta,Jianbo Xiao.  (2018-09-04)  Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach..  Food chemistry,  270  (257-263).  [PMID:30174044]
12. Jie Bai,Shengyu Zhao,Xiaoqing Fan,Yonghui Chen,Xiaowen Zou,Minwan Hu,Baolian Wang,Jing Jin,Xiaojian Wang,Jinping Hu,Dan Zhang,Yan Li.  (2019-02-23)  Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure-activity relationships..  Toxicology and applied pharmacology,  369  (49-59).  [PMID:30790579]
13. Richard Lantz,Brian Busbee,Ewa P Wojcikiewicz,Deguo Du.  (2020-05-28)  Flavonoids with Vicinal Hydroxyl Groups Inhibit Human Calcitonin Amyloid Formation..  Chemistry (Weinheim an der Bergstrasse, Germany),  26  ((57)): (13063-13071).  [PMID:32458489]
14. C Lapouge,J P Cornard.  (2006-07-13)  Time dependent density functional theory study of electronic absorption properties of lead(II) complexes with a series of hydroxyflavones..  The journal of physical chemistry. A,  109  ((30)): (6752-6761).  [PMID:16834029]
15. Yajing Fang,Mengmeng Xia,Fuqiang Liang,Weiwei Cao,Siyi Pan,Xiaoyun Xu.  (2019-01-29)  Establishment and Use of Human Mouth Epidermal Carcinoma (KB) Cells Overexpressing P-Glycoprotein To Characterize Structure Requirements for Flavonoids Transported by the Efflux Transporter..  Journal of agricultural and food chemistry,  67  ((8)): (2350-2360).  [PMID:30688455]
16. Bogusław Buszewski,Petar Žuvela,Gulyaim Sagandykova,Justyna Walczak-Skierska,Paweł Pomastowski,Jonathan David,Ming Wah Wong.  (2020-03-21)  Mechanistic Chromatographic Column Characterization for the Analysis of Flavonoids Using Quantitative Structure-Retention Relationships Based on Density Functional Theory..  International journal of molecular sciences,  21  ((6)): [PMID:32192096]
17. Stanislav Sukhikh,Svetlana Noskova,Svetlana Ivanova,Liubov Skrypnik,Artem Pungin,Elena Ulrikh,Evgeny Chupakhin,Olga Babich.  (2021-07-03)  Study of the Properties of In Vitro Dactylorhiza maculata (L.) Soó (Family Orchidaceae) Extracts..  Plants (Basel, Switzerland),  10  ((7)): [PMID:34209935]
18. Li-Feng Li, Meng-Di Wang, Chen-Yang Zhang, Meng-Yao Jin, Hua-Lei Chen, Huan Luo, Tian-Yu Hou, Zhi-Jun Zhang, He Li.  (2025)  Influence of hydroxyl substitution on the inhibition of flavonoids in advanced glycation end-products formation in glucose-lysine-arginine Maillard reaction models.  FOOD RESEARCH INTERNATIONAL,  207  (116068).  [PMID:40086959] [10.1016/j.foodres.2025.116068]

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