基本描述

别名	L-(+)-对羟基苯甘氨酸 \| (S)-(+)-2-氨基-2-(4-羟苯基)乙酸 \| 羟苯甘氨酸 \| L-(+)-2-(4-羟苯基)甘氨酸
英文别名	AC-24628 \| DS-11081 \| p-Hydroxy-L-phenylglycine \| (S)-2-AMINO-2-(4-HYDROXYPHENYL)ACETIC ACID \| (S)-Amino-(4-hydroxyphenyl)acetic acid \| 4-Hydroxy-L-phenylglycine \| CAS-32462-30-9 \| H-Phg(4-OH)-OH \| Oxfenicina \| BDBM50403035 \| H1389 \| SCHEMBL122315 \| UNII-
规格或纯度	≥99%
英文名称	4-Hydroxy-L-(+)-2-phenylglycine
运输条件	常规运输
作用类型	抑制剂
纯度	≥99%

关联靶点（人）

CPT2 Tchem Carnitine palmitoyltransferase 2 (510 活性数据)

点击查看靶蛋白信息： CPT2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SLC1A4 Tbio Neutral amino acid transporter A (18 活性数据)

点击查看靶蛋白信息： SLC1A4

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

KB (17409 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CPT1A Tchem Carnitine O-palmitoyltransferase 1, liver isoform (507 活性数据)

点击查看靶蛋白信息： CPT1A

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CPT1B Tchem Carnitine O-palmitoyltransferase 1, muscle isoform (497 活性数据)

点击查看靶蛋白信息： CPT1B

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SLC1A5 Tchem Neutral amino acid transporter B(0) (65 活性数据)

点击查看靶蛋白信息： SLC1A5

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Galc Galactocerebrosidase (11 活性数据)

点击查看靶蛋白信息： Galc

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 活性数据)

点击查看靶蛋白信息： rep

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Grin1 Glutamate NMDA receptor (6467 活性数据)

点击查看靶蛋白信息： Grin1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Slc1a5 Amino acid transporter (271 活性数据)

点击查看靶蛋白信息： Slc1a5

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Slc7a10 Asc-type amino acid transporter 1 (14 活性数据)

点击查看靶蛋白信息： Slc7a10

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	488183269
分子类型	小分子
IIUPAC Name	(2S)-2-amino-2-(4-hydroxyphenyl)acetic acid
INCHI	1S/C8H9NO3/c9-7(8(11)12)5-1-3-6(10)4-2-5/h1-4,7,10H,9H2,(H,11,12)/t7-/m0/s1
InChi Key	LJCWONGJFPCTTL-ZETCQYMHSA-N
Smiles	C1=CC(=CC=C1C(C(=O)O)N)O
Isomeric SMILES	C1=CC(=CC=C1[C@@H](C(=O)O)N)O
分子量	167.16
Beilstein号	3589850
Reaxy-Rn	513130
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=513130&ln=

化学和物理性质

比旋光度	155° (C=1,1mol/L HCl)
熔点	214°C(dec.)(lit.)
分子量	167.160 g/mol
XLogP3	-2.100
氢键供体数Hydrogen Bond Donor Count	3
氢键受体数Hydrogen Bond Acceptor Count	4
可旋转键计数Rotatable Bond Count	2
精确质量Exact Mass	167.058 Da
单同位素质量Monoisotopic Mass	167.058 Da
拓扑极表面积Topological Polar Surface Area	83.600 Å²
重原子数Heavy Atom Count	12
形式电荷Formal Charge	0
复杂度Complexity	164.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	1
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS07
信号词	警告
危险声明	H302: 吞食有害 H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany	3
个人防护装备	dust mask type N95 (US)， Eyeshields， Gloves

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到13个结果

批号(Lot Number)	证书类型	货号
G2101187	分析证书	H157171
G2101190	分析证书	H157171
G2101194	分析证书	H157171
E2415394	分析证书	H157171
C2307484	分析证书	H157171
C2307486	分析证书	H157171
C2307498	分析证书	H157171
C2307509	分析证书	H157171
C2307461	分析证书	H157171
C2307462	分析证书	H157171
A1922047	分析证书	H157171
I2207779	分析证书	H157171
I2207780	分析证书	H157171

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引用文献

1. Gertrud Angsten,Sven Valind,Reijo Takalo,Henrik Neu,Staffan Meurling,Bengt Långström. (2005-06-29) Inhibition of carnitine-acyl transferase I by oxfenicine studied in vivo with [11C]-labeled fatty acids.. Nuclear medicine and biology, 32 ((5)): (495-503). [PMID:15982580]
2. Tom L Broderick,Bryan Glick. (2005-08-24) Effect of gender and fatty acids on ischemic recovery of contractile and pump function in the rat heart.. Gender medicine, 1 ((2)): (86-99). [PMID:16115587]
3. Steven A Unger,Jennifer A Kennedy,Kate McFadden-Lewis,Kirsty Minerds,Geraldine A Murphy,John D Horowitz. (2005-11-25) Dissociation between metabolic and efficiency effects of perhexiline in normoxic rat myocardium.. Journal of cardiovascular pharmacology, 46 ((6)): (849-855). [PMID:16306812]
4. Naotoshi Hirota,Shuichi Otabe,Hitomi Nakayama,Xiaohong Yuan,Kentaro Yamada. (2006-05-19) Sequential activation of caspases and synergistic beta-cell cytotoxicity by palmitate and anti-Fas antibodies.. Life sciences, 79 ((13)): (1312-1316). [PMID:16707142]
5. M G Marina Prendes,J V García,G Testoni,M A Fernández,J C Perazzo,E A Savino,A Varela. (2006-06-07) Influence of fasting on the effects of dimethylamiloride and oxfenicine on ischaemic-reperfused rat hearts.. Archives of physiology and biochemistry, 112 ((1)): (31-36). [PMID:16754201]
6. Khalid Abozguia,Kieran Clarke,Leong Lee,Michael Frenneaux. (2006-08-26) Modification of myocardial substrate use as a therapy for heart failure.. Nature clinical practice. Cardiovascular medicine, 3 ((9)): (490-498). [PMID:16932766]
7. Xihou Yin,T Mark Zabriskie. (2006-09-29) The enduracidin biosynthetic gene cluster from Streptomyces fungicidicus.. Microbiology (Reading, England), 152 ((Pt 10)): (2969-2983). [PMID:17005978]
8. Isidore C Okere,Margaret P Chandler,Tracy A McElfresh,Julie H Rennison,Theodore A Kung,Brian D Hoit,Paul Ernsberger,Martin E Young,William C Stanley. (2007-01-05) Carnitine palmitoyl transferase-I inhibition is not associated with cardiac hypertrophy in rats fed a high-fat diet.. Clinical and experimental pharmacology & physiology, 34 ((1-2)): (113-119). [PMID:17201745]
9. Lufang Zhou,Hazel Huang,Celvie L Yuan,Wendy Keung,Gary D Lopaschuk,William C Stanley. (2007-12-18) Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation.. American journal of physiology. Heart and circulatory physiology, 294 ((2)): (H954-H960). [PMID:18083904]
10. Manoj Gandhi,Barry A Finegan,Alexander S Clanachan. (2008-04-15) Role of glucose metabolism in the recovery of postischemic LV mechanical function: effects of insulin and other metabolic modulators.. American journal of physiology. Heart and circulatory physiology, 294 ((6)): (H2576-H2586). [PMID:18408129]
11. Jeanne M Davidsen,Craig A Townsend. (2008-11-26) Identification and characterization of NocR as a positive transcriptional regulator of the beta-lactam nocardicin A in Nocardia uniformis.. Journal of bacteriology, 191 ((3)): (1066-1077). [PMID:19028891]
12. Mònica Prieto,Silvia Mayor,Paul Lloyd-Williams,Ernest Giralt. (2009-10-30) Use of the SPhos ligand to suppress racemization in arylpinacolboronate ester Suzuki couplings involving alpha-amino acids. Synthesis of biaryl derivatives of 4-hydroxyphenylglycine, tyrosine, and tryptophan.. The Journal of organic chemistry, 74 ((23)): (9202-9205). [PMID:19863122]
13. David Hauton,Germaine M Caldwell. (2012-01-10) Cardiac lipoprotein lipase activity in the hypertrophied heart may be regulated by fatty acid flux.. Biochimica et biophysica acta, 1821 ((4)): (627-636). [PMID:22226882]
14. Stephan Kastner,Sebastian Müller,Lavanya Natesan,Gabriele M König,Reinhard Guthke,Markus Nett. (2012-02-07) 4-Hydroxyphenylglycine biosynthesis in Herpetosiphon aurantiacus: a case of gene duplication and catalytic divergence.. Archives of microbiology, 194 ((6)): (557-566). [PMID:22307823]
15. Gerald Maarman,Erna Marais,Amanda Lochner,Eugene F du Toit. (2012-03-13) Effect of chronic CPT-1 inhibition on myocardial ischemia-reperfusion injury (I/R) in a model of diet-induced obesity.. Cardiovascular drugs and therapy, 26 ((3)): (205-216). [PMID:22407171]
16. Wendy Keung,John R Ussher,Jagdip S Jaswal,Monique Raubenheimer,Victoria H M Lam,Cory S Wagg,Gary D Lopaschuk. (2012-11-10) Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice.. Diabetes, 62 ((3)): (711-720). [PMID:23139350]
17. Heinz Rupp,Thomas P Rupp,Bernhard Maisch. (2005-05-26) Fatty acid oxidation inhibition with PPARalpha activation (FOXIB/PPARalpha) for normalizing gene expression in heart failure?. Cardiovascular research, 66 ((3)): (423-426). [PMID:15914105]
18. Monica Prieto,Silvia Mayor,Katy Rodríguez,Paul Lloyd-Williams,Ernest Giralt. (2007-01-27) Racemization in suzuki couplings: a quantitative study using 4-hydroxyphenylglycine and tyrosine derivatives as probe molecules.. The Journal of organic chemistry, 72 ((3)): (1047-1050). [PMID:17253834]
19. Chung-Jen Chiang,Jong-Tzer Chern,Jen-You Wang,Yun-Peng Chao. (2008-07-19) Facile immobilization of evolved agrobacterium radiobacter carbamoylase with high thermal and oxidative stability.. Journal of agricultural and food chemistry, 56 ((15)): (6348-6354). [PMID:18636689]
20. Tony Ly,Ryan R Julian. (2009-03-17) Tracking radical migration in large hydrogen deficient peptides with covalent labels: facile movement does not equal indiscriminate fragmentation.. Journal of the American Society for Mass Spectrometry, 20 ((6)): (1148-1158). [PMID:19286394]
21. H Yu,S Yang,W Jiang,Y Yang. (2010-02-09) Efficient biocatalytic production of D-4-hydroxyphenylglycine by whole cells of recombinant Ralstonia pickettii.. Folia microbiologica, 54 ((6)): (509-515). [PMID:20140718]
22. M G Marina Prendes,R Hermann,M E Torresin,P Souto,S Tallis,E A Savino,A Varela,M M Jaitovich. (2011-05-07) Involvement of energetic metabolism in the effects of ischemic postconditioning on the ischemic-reperfused heart of fed and fasted rats.. The journal of physiological sciences : JPS, 61 ((4)): (303-312). [PMID:21547611]
23. Rong Shi,Christine Munger,Lindsay Kalan,Traian Sulea,Gerard D Wright,Miroslaw Cygler. (2012-07-04) Sulfonation of glycopeptide antibiotics by sulfotransferase StaL depends on conformational flexibility of aglycone scaffold.. Proceedings of the National Academy of Sciences of the United States of America, 109 ((29)): (11824-11829). [PMID:22753479]

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

=

浓度

x

体积

x

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

x

体积 1 (V1)

=

浓度 2 (C2)

x

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

=

质量（小瓶）

÷

所需的复溶浓度

货号 (SKU)	包装规格	是否现货
H157171-1g	1g	现货
H157171-5g	5g	现货
H157171-25g	25g	现货
H157171-100g	100g	现货

4-羟基-L-(+)-2-苯基甘氨酸

库存信息

库存信息

库存信息

库存信息

基本描述

关联靶点（人）

关联靶点（其它种属）

作用机制

名称和识别符

化学和物理性质

安全和危险性（GHS）

质检证书（CoA,COO,BSE/TSE 和分析图谱)

显示更多⌵

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器