基本描述

别名	骆驼蓬碱
英文别名	7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole \| HARMINE \| HMS3885E10 \| Spectrum5_001914 \| 9H-Pyrido(3,4-b)indole, 7-methoxy-1-methyl- \| HY-N0737A \| Spectrum_001128 \| 5-23-12-00237 (Beilstein Handbook Reference) \| NCGC00016435-01 \| NCGC00016435-03 \| SMR0012332
规格或纯度	Moligand™, ≥98%
英文名称	Harmine
生化机理	DYRK1A的强效和选择性抑制剂（酪氨酸磷酸化和调节的双重特异性激酶）。（IC 50值为0.08（DYRK1A），0.9（DYRK2），0.8（DYRK3），4.3（PIM3）和1.5μM（CK1））。5-HT拮抗剂和MAO抑制剂。
运输条件	常规运输
作用类型	抑制剂
作用机制	双重特异性酪氨酸磷酸化调节激酶 1A 抑制剂；双重特异性酪氨酸磷酸化调节激酶 1B 抑制剂
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	不溶于水。中枢神经系统兴奋剂。
纯度	≥98%

关联靶点（人）

CYP1A2 Tchem 细胞色素 P450 1A2(Cytochrome P450 1A2) (1 活性数据)

点击查看靶蛋白信息： CYP1A2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

DYRK1B Tchem 双特异性酪氨酸磷酸化调节激酶 1B(Dual specificity tyrosine-phosphorylation-regulated kinase 1B) (2 活性数据)

点击查看靶蛋白信息： DYRK1B

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

DYRK1A Tchem 双特异性酪氨酸磷酸化调节激酶 1A(Dual specificity tyrosine-phosphorylation-regulated kinase 1A) (6 活性数据)

点击查看靶蛋白信息： DYRK1A

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

MAOA Tclin 胺氧化酶[含黄素]A(Amine oxidase [flavin-containing] A) (3 活性数据)

点击查看靶蛋白信息： MAOA

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

CLK1 Tchem 双特异性蛋白激酶 CLK1(Dual specificity protein kinase CLK1) (4 活性数据)

点击查看靶蛋白信息： CLK1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

NISCH Tclin 尼斯卡林(Nischarin) (1 活性数据)

点击查看靶蛋白信息： NISCH

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

名称和识别符

PubChem SID	504763320
EC号	207-131-4
分子类型	小分子
IIUPAC Name	7-methoxy-1-methyl-9H-pyrido[3,4-b]indole
INCHI	1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
InChi Key	BXNJHAXVSOCGBA-UHFFFAOYSA-N
Smiles	CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC
Isomeric SMILES	CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC
关联CAS	442-51-3
MeSH Entry Terms	9H-Pyrido(3,4-b)indole, 7-methoxy-1-methyl-;Banisterine;Harmine;Leucoharmine;Telepathine;Yageine
分子量	212.25
Beilstein号	178813
Reaxy-Rn	178813
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=178813&ln=

化学和物理性质

密度	1.252
熔点	262-264°C
分子量	212.250 g/mol
XLogP3	3.600
氢键供体数Hydrogen Bond Donor Count	1
氢键受体数Hydrogen Bond Acceptor Count	2
可旋转键计数Rotatable Bond Count	1
精确质量Exact Mass	212.095 Da
单同位素质量Monoisotopic Mass	212.095 Da
拓扑极表面积Topological Polar Surface Area	37.900 Å²
重原子数Heavy Atom Count	16
形式电荷Formal Charge	0
复杂度Complexity	258.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS07
信号词	警告
危险声明	H302: 吞食有害 H312: 皮肤接触有害 H319: 引起严重眼睛刺激 H332: 吸入有害
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P317: 寻求紧急医疗救助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。
WGK Germany	3
RTECS	UV0175000
Merck Index	4616
个人防护装备	dust mask type N95 (US),Eyeshields,Gloves

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C of A & Other Certificates(BSE/TSE, COO):

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找到4个结果

批号(Lot Number)	证书类型	货号
L2115107	分析证书	H107067
L2115116	分析证书	H107067
E1916020	分析证书	H107067
G2319530	分析证书	H107067

此产品的引用文献

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引用文献

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货号 (SKU)	包装规格	是否现货	价格	数量
H107067-250mg	250mg	现货
H107067-1g	1g	现货

哈尔碱, 双重特异性酪氨酸磷酸化调节激酶 1A 抑制剂；双重特异性酪氨酸磷酸化调节激酶 1B 抑制剂

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