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氮氧自由基哌啶醇

膜可渗透的超氧化物清除剂。SOD模拟。
    级别和纯度:
  • ≥98%
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货号 (SKU) 包装规格 是否现货 价格 数量
H104510-25g
25g 现货 Stock Image
H104510-100g
100g 现货 Stock Image
H104510-500g
500g 现货 Stock Image
H104510-2.5kg
2.5kg 现货 Stock Image

基本描述

别名 4-羟基-TEMPO 自由基 | 哌啶醇氧化物 | TEMPOL 自由基 | 4-羟基-2,2,6,6-四甲基哌啶1-氧基 自由基
英文别名 4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical | 4-Hydroxy-TEMPO Free Radical | TEMPOL Free Radical
规格或纯度 ≥98%
英文名称 4-Hydroxy-TEMPO
生化机理 膜可渗透的超氧化物清除剂。SOD模拟。减轻超氧阴离子和过亚硝酸盐引起的炎症。降低氧化应激。
应用 4-羟基-TEMPO(HO-TEMPO)可用作催化剂将醇氧化成相应的醛。它可用于制备TEMPO聚合物催化体系,该体系可用于多种伯醇的Anelli氧化。它可以用作合成4-(2,2,6,6-四甲基-1-氧基-4-哌啶氧基)丁基溴的起始试剂。 用于研究生物化合物和聚合物的自旋标记物。 由衍生化TEMPO丙炔醚以及随后与氟叠氮化物发生"点击"反应,制备氟标记的TEMPO衍生物。该TEMPO衍生物已被证明是用漂白剂氧化醇的高效催化剂。 自旋标记试剂,用于鉴定 NK1 受体的拮抗剂和激动剂结合位点。也可用于电子自旋共振光谱法测定心肌中活性氧的生成。TEMPOL 可保护过量表达 CYP2E1 的细胞免受花生四烯酸的毒性损伤。
储存温度 2-8°C储存,充氩
运输条件 冰袋运输
备注 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。
产品介绍

TEMPOL is a superoxide dismutase mimetic that belongs to a class of non-thiol-containing radiation protectors, and has the ability to permeate the membrane. In the presence of TEMPOL, cerebral vessel remodeling is blocked and collagen IV mRNA expression levels are elevated in normotensive and hypertensive rat studies. TEMPOL has been shown to restore the oxidative stress and cardiac dysfunction induced by TNF-α and in PC-12 cells has revealed neuroprotective effects. Additionally, it has shown to decrease blood pressure and sympathetic nerve activity in DOCA-salt rat studies.

TEMPOL is a superoxide dismutase mimetic that belongs to a class of non-thiol-containing radiation protectors, and has the ability to permeate the membrane. In the presence of TEMPOL, cerebral vessel remodeling is blocked and collagen IV mRNA expression levels are elevated in normotensive and hypertensive rat studies. TEMPOL has been shown to restore the oxidative stress and cardiac dysfunction induced by TNF-α and in PC-12 cells has revealed neuroprotective effects. Additionally, it has shown to decrease blood pressure and sympathetic nerve activity in DOCA-salt rat studies.


product description:

4-Hydroxy-TEMPO is a 4-substituted 2,2,6,6-tetramethylpiperidyl-1-oxy (TEMPO) derivative. It is a low-molecular weight compound and has been proposed as superoxide dismutase mimic.

纯度 ≥98%

关联靶点(人)

PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HL-60 (67320 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
A549 (127892 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NCI-H1299 (3248 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HUVEC (11049 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ABCB11 Tchem Bile salt export pump (2311 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点(其它种属)

Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Aorta (2975 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
661W (31 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

EC号 218-760-9
分子类型 小分子
Isomeric SMILES CC1(CC(CC(N1[O])(C)C)O)C
分子量 172.24
Beilstein号 1422990
Reaxy-Rn 11328213

化学和物理性质

溶解性 易溶于乙醇、苯等有机溶剂,易溶于水。
密度 1.187
敏感性 对光线和湿度敏感
闪点(℉) 294.80℉
闪点(℃) 146℃
熔点 69-71°C
分子量 172.240 g/mol
XLogP3 0.900
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 2
可旋转键计数Rotatable Bond Count 0
精确质量Exact Mass 172.134 Da
单同位素质量Monoisotopic Mass 172.134 Da
拓扑极表面积Topological Polar Surface Area 24.500 Ų
重原子数Heavy Atom Count 12
形式电荷Formal Charge 0
复杂度Complexity 159.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性(GHS)

象形图 GHS07
信号词 警告
危险声明

H302: 吞食有害

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激

预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P264: 处理后要彻底洗手。

P301+P312: 如误吞咽:如感觉不适,呼叫急救中心/医生。

P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。

P404: 存放在密闭的容器中。

P403+P235: 存放在通风良好的地方。保持低温。

P501: 将内容物/容器处理到。。。

WGK Germany 1
RTECS TN8991000
Merck Index 9141
个人防护装备 dust mask type N95 (US),Eyeshields,Gloves

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此产品的引用文献

引用文献

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2. Yirui Zhao, Hongshun Hao, Jiaqi Zhong, Gongliang Zhang, Jingran Bi, Shuang Yan, Feng Hong, Hongman Hou.  (2023)  Photothermocatalytic sterilization activity enhancement and mechanism evaluation of WO3/TpPa-1/N-Nb2CTx constructed with a 2D Z-type heterojunction WO3/TpPa-1 and 2D co-catalyst Nb2CTx.  CERAMICS INTERNATIONAL,  [10.1016/j.ceramint.2023.11.284]
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11. Ruijin Li, Danlian Huang, Yashi Chen, Guangfu Wang, Zhen Wei, Wei Zhou, Ruihao Xiao.  (2023)  Selective value-added conversion of lignin derivatives over heterogeneous catalysts of TEMPO-functionalized metal-organic frameworks.  Journal of Environmental Chemical Engineering,  11  (109700).  [10.1016/j.jece.2023.109700]
12. Yifeng Zeng, Fan Wang, Dongqin He, Jianqiang Sun, Jun Li, Hongwei Luo, Xiangliang Pan.  (2023)  Role of superoxide radical and singlet oxygen in peroxymonosulfate activation by iron-doped bone char for efficient acetaminophen degradation.  CHEMICAL ENGINEERING JOURNAL,  459  (141642).  [10.1016/j.cej.2023.141642]
13. Wenxi Wang, Junjie Zhang, Zhiran Hou, Pei Chen, Xu Zhou, Wei Wang, Fatang Tan, Xinyun Wang, Xueliang Qiao.  (2023)  Improvement of Carbonyl Groups and Surface Defects in Carbon Nanotubes to Activate Peroxydisulfate for Tetracycline Degradation.  Nanomaterials,  13  (1): (216).  [PMID:36616125] [10.3390/nano13010216]
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15. Jing Wu, Jiabing Li, Gary Owens, Zuliang Chen.  (2023)  Toward green nano adsorbents and catalysts: Highly active Fe/Mn nanoparticles for enhanced oxidation of oxytetracycline and levofloxacin.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  632  (299).  [PMID:36435071] [10.1016/j.jcis.2022.11.074]
16. Fucheng Yu, Haiyang Chen, Xin Tian, Yadong Zhou, Junpeng Cui, Cuixia Li, Jianbin Zhang, Xianxi Tang, Yangshuo Liu.  (2023)  Studies on the preparation and optical properties of ZnO hollow nanosphere/ZnCo2S4 nanoparticle composite photocatalyst.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,  657  (130524).  [10.1016/j.colsurfa.2022.130524]
17. Tingting Liu, Fanyu Yang, Liming Wang, Liang Pei, Yushan Hu, Ru Li, Kang Hou, Tianlong Ren.  (2022)  Synergistic Effect of Charge Separation and Multiple Reactive Oxygen Species Generation on Boosting Photocatalytic Degradation of Fluvastatin by ZnIn2S4/Bi2WO6 Z-Scheme Heterostructured Photocatalytst.  Toxics,  10  (10): (555).  [PMID:36287836] [10.3390/toxics10100555]
18. Lu-Lu Wang, Shun-Feng Jiang, Jing Huang, Hong Jiang.  (2022)  Oxygen-doped biochar for the activation of ferrate for the highly efficient degradation of sulfadiazine with a distinct pathway.  Journal of Environmental Chemical Engineering,  10  (108537).  [10.1016/j.jece.2022.108537]
19. Mingjie Cai, Yanping Liu, Kexin Dong, Chunchun Wang, Shijie Li.  (2023)  A novel S-scheme heterojunction of Cd0.5Zn0.5S/BiOCl with oxygen defects for antibiotic norfloxacin photodegradation: Performance, mechanism, and intermediates toxicity evaluation.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  629  (276).  [PMID:36081207] [10.1016/j.jcis.2022.08.136]
20. Wu Xiang-Feng, Fu Yun-Xuan, Chang Tian-Long, Jia Yun-Ning, Shang Jia-Lu, Wang Hui, Fan Zi-Hao, Wang Chen-Xu, Su Jun-Zhang, Ci Li-Jie.  (2022)  Simultaneous introduction of surface plasmon resonance effect and oxygen vacancies onto Bi/Bi2O3 heterostructure for enhancing visible-light photocatalysis.  APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING,  128  (9): (1-10).  [10.1007/s00339-022-05899-x]
21. Zhixia Wang, Hang Song.  (2022)  The synthesis of quaternary N-alkyl tropinium cationic surfactants and study on their properties: effect of temperature, hydrophobic chain length and anions.  JOURNAL OF MOLECULAR STRUCTURE,  1268  (133732).  [10.1016/j.molstruc.2022.133732]
22. Quan Wang, Xueqing Liu, Zhe Qiang, Zhendong Hu, Xin Cui, Huaixiao Wei, Jinjin Hu, Yuming Xia, Shuohan Huang, Jianming Zhang, Kun (Kelvin) Fu, Yuwei Chen.  (2022)  Cellulose nanocrystal enhanced, high dielectric 3D printing composite resin for energy applications.  COMPOSITES SCIENCE AND TECHNOLOGY,  227  (109601).  [10.1016/j.compscitech.2022.109601]
23. Chunchun Wang, Shijie Li, Mingjie Cai, Ruyu Yan, Kexin Dong, Junlei Zhang, Yanping Liu.  (2022)  Rationally designed tetra (4-carboxyphenyl) porphyrin/graphene quantum dots/bismuth molybdate Z-scheme heterojunction for tetracycline degradation and Cr(VI) reduction: Performance, mechanism, intermediate toxicity appraisement.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  619  (307).  [PMID:35398762] [10.1016/j.jcis.2022.03.075]
24. Jiaxin Xu, Xiuquan Lan, Jianhua Cheng, Xinhui Zhou.  (2022)  Facile synthesis of g-C3N4/Ag2C2O4 heterojunction composite membrane with efficient visible light photocatalytic activity for water disinfection.  CHEMOSPHERE,  295  (133841).  [PMID:35131277] [10.1016/j.chemosphere.2022.133841]
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26. Tianyou Chen, Wei Xiao, Zihao Wang, Pengfei Gan, Changfeng Yi, Zushun Xu.  (2022)  Pyrene-Containing Polymer-Supported Cu/TEMPO Catalytic Systems: Aromatic Stacking-Enhanced Cooperative Catalysis.  Journal of Physical Chemistry C,  126  (1): (309–316).  [10.1021/acs.jpcc.1c09972]
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30. Lifen Wang, Yonggang Liu, Yinjun Lin, Yonghao Yu, Xueying Zhang, Ruiqin Zhang, Yunpu Zhai.  (2021)  One-step synthesis of novel Ni-doped Cu2(OH)3F Fenton-like catalyst driven by visible light: Single activity and synergistic effect enhanced by bimetallic cooperation.  JOURNAL OF ALLOYS AND COMPOUNDS,  887  (161424).  [10.1016/j.jallcom.2021.161424]
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33. Xinbo Jing, Xueying Peng, Xiyin Sun, Wu Zhou, Wei Wang, Shufen Wang.  (2019)  Design and synthesis of Mo2C/MoO3 with enhanced visible-light photocatalytic performance for reduction of Cr (VI) and degradation of organic pollutants.  MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING,  100  (262).  [10.1016/j.mssp.2019.05.004]
34. Liu Shaojie, Sun Tingting, Yang Desheng, Cao Meng, Liang Huazhe.  (2018)  Polyacrylic acid supported TEMPO for selective catalytic oxidation of cellulose: recovered by its pH sensitivity.  CELLULOSE,  25  (10): (5687-5696).  [10.1007/s10570-018-2012-z]
35. Li-rong Nie, Hang Song, Alula Yohannes, Siwei Liang, Shun Yao.  (2018)  Extraction in cholinium-based magnetic ionic liquid aqueous two-phase system for the determination of berberine hydrochloride in Rhizoma coptidis.  RSC Advances,  (44): (25201-25209).  [PMID:35542128] [10.1039/C8RA01745J]
36. Hong-Fei Shi, Gang Yan, Yi Zhang, Hua-Qiao Tan, Wen-Zhe Zhou, Yuan-Yuan Ma, Yang-Guang Li, Weilin Chen, En-Bo Wang.  (2017)  Ag/AgxH3–xPMo12O40 Nanowires with Enhanced Visible-Light-Driven Photocatalytic Performance.  ACS Applied Materials & Interfaces,  (1): (422–430).  [PMID:27960252] [10.1021/acsami.6b13009]
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