| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| G655813-1ml |
1ml |
期货  |
|
| 别名 | GPR40 激动剂 4 |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | GPR40 agonist 4 |
| 生化机理 | GPR40 激动剂 4 是一种强效的游离脂肪酸受体 1（FFA1/ GPR40）激动剂，pEC 50 为 7.54。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 产品介绍 |
GPR40 agonist 4 is a potent free fatty acid receptor 1 ( FFA1/ GPR40 ) agonist with a pEC 50 of 7.54. In Vitro GPR40 agonist 4 tends to have a low risk of activating caspase-3/7. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Single oral administration of GPR40 agonist 4 (compound 20) robustly reduces the plasma glucose excursion and enhances insulin secretion during an oral glucose tolerance test (OGTT) in a dose-dependent manner from 1 to 10 mg/kg when GPR40 agonist 4 is dosed 60 min prior to the oral glucose challenge. The area under the curve of blood glucose (AUC 0-120min ) and blood insulin (AUC 0-120min ) reveal that the minimum effective dose of GPR40 agonist 4 is 3 mg/kg. The hyperglycemia state is also markedly improved in GPR40 agonist 4 (20 mg/kg) treated group . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:pEC 50 : 7.54 (FFA1/GPR40) |
| 分子类型 | 小分子 |
|---|---|
| Isomeric SMILES | C1=CC=C(C(=C1)C2=CC=CC(=C2)COC3=CC=C(C=C3)S(=O)(=O)CC(=O)O)Cl |
| PubChem CID | 131842087 |
| 分子量 | 416.87 |
首页
400-620-6333
