| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| G654724-1ml |
1ml |
期货  |
|
| 规格或纯度 | Moligand™, 10mM in DMSO |
|---|---|
| 英文名称 | GNE-131 |
| 生化机理 | GNE-131 是一种强效的人类钠通道 NaV1.7 选择性抑制剂，其 IC 50 为 3 nM。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | Na 抑制剂 v1.1；Na 抑制剂 v1.2；Na 抑制剂 v1.5；Na 抑制剂 v1.6；Na 抑制剂 v1.7 |
| 产品介绍 |
GNE-131 是有效的人类钠离子通道 NaV1.7(hNaV1.7)选择性抑制剂，IC50为 3 nM GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7 , with an IC 50 of 3 nM. In Vitro GNE-131 (Compound 13) shows moderate clearance in human liver microsomes and excellent functional activity against human NaV1.7 with an IC 50 of 0.003±0.001 μM. GNE-131 shows excellent potency, good in vitro metabolic stability. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo GNE-131 shows low in vivo clearance in mouse, rat, and dog. GNE-131 also displays excellent efficacy in a transgenic mouse model of induced pain . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Na v 1.7 3 nM (IC 50 ) |
| 分子类型 | 小分子 |
|---|---|
| Isomeric SMILES | C1CC1C2=CN3C(=NN=C3NS(=O)(=O)C4CC4)C=C2OCC56CC7CC(C5)CC(C7)C6 |
| PubChem CID | 91666633 |
| 分子量 | 442.57 |
首页
400-620-6333
