| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| G648944-5mg |
5mg |
期货  |
|
| 英文别名 | BDBM50084948 | (2e)-3-[4-[(1e)-1-(4-hydroxyphenyl)-2-phenyl-1-butenyl]phenyl]-2-propenoic acid | SCHEMBL5070366 | 3-{4-[1-(4-Hydroxy-phenyl)-2-phenyl-but-1-enyl]-phenyl}-acrylic acid | (E)-3-(4-((E)-1-(4-Hydroxyphenyl)-2-phenylbut-1-en-1-yl)phenyl)acrylic |
|---|---|
| 规格或纯度 | ≥98% |
| 英文名称 | GW7604 |
| 生化机理 | GW7604 是一种抗雌激素药物。GW7604 是 GW5638 的代谢物，后者是一种高亲和力雌激素受体（ER）拮抗剂。 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
GW7604 is an antiestrogen. GW7604 is the metabolite of GW5638, which is a high affinity estrogen receptor (ER) antagonist. In Vitro GW7604 is the presumed metabolite of GW5638 in breast (MCF-7) and endometrial (ECC-1) cell lines. GW7604 (0.1 nM-1 μM; 24 hours) inhibits both Estradiol (1 nM) and 4-hydroxytamoxifen (4-OHT; 10 and 100 nM) induction of TGF-alpha in a concentration related manner (1-1000 nM) in MDA-MB-231 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: MDA-MB-231 cells Concentration: 0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM Incubation Time: 24 hours Result: Blocked the effect of estradiol (E2; 1 n M) in a concentration-related manner. Form:Solid |
| 纯度 | ≥98% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (E)-3-[4-[(E)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid |
| INCHI | 1S/C25H22O3/c1-2-23(19-6-4-3-5-7-19)25(21-13-15-22(26)16-14-21)20-11-8-18(9-12-20)10-17-24(27)28/h3-17,26H,2H2,1H3,(H,27,28)/b17-10+,25-23+ |
| InChi Key | SCVIEONTACSLJA-YGCRUXFTSA-N |
| Smiles | CCC(=C(C1=CC=C(C=C1)C=CC(=O)O)C2=CC=C(C=C2)O)C3=CC=CC=C3 |
| Isomeric SMILES | CC/C(=C(/C1=CC=C(C=C1)/C=C/C(=O)O)\C2=CC=C(C=C2)O)/C3=CC=CC=C3 |
| PubChem CID | 9799518 |
| 分子量 | 370.45 |
| 分子量 | 370.400 g/mol |
|---|---|
| XLogP3 | 6.700 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 6 |
| 精确质量Exact Mass | 370.157 Da |
| 单同位素质量Monoisotopic Mass | 370.157 Da |
| 拓扑极表面积Topological Polar Surface Area | 57.500 Ų |
| 重原子数Heavy Atom Count | 28 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 554.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 2 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 2 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
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