GAT211

COA

级别和纯度:

≥99%

CAS编号: 102704-40-5
分子式: C₂₂H₁₈N₂O₂
分子量: 342.39
PubChem编号: 4402318

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货
G646624-5mg	5mg	期货
G646624-10mg	10mg	期货
G646624-25mg	25mg	期货
G646624-50mg	50mg	期货
G646624-100mg	100mg	期货

查看相关系列

Cannabinoid Receptor (79) Class A GPCR (8201) GPCR/G Protein (3179) 神经元信号传导 (3320)

Skip to the end of the images gallery

Skip to the beginning of the images gallery

基本描述

规格或纯度	≥99%
英文名称	GAT211
生化机理	GAT211 是一种大麻素 1 受体（CB1R）正异位调节剂（PAM）。GAT211 可激活 cAMP 和 β-arrestin2，其 EC 50 值分别为 260 nM 和 650 nM。GAT211 可抑制神经病理性疼痛和/或炎症性疼痛。
储存温度	-20°C储存
运输条件	超低温冰袋运输
作用类型	激动剂
产品介绍	GAT211 is a cannabinoid 1 receptor (CB1R) positive allosteric modulator (PAM). GAT211 activates cAMP and β-arrestin2 with EC 50 values of 260 nM and 650 nM, respectively. GAT211 inhibits GAT211 can be used for neuropathic and/or inflammatory pain research In Vitro GAT211 is stable in both human- and rat-liver microsomal incubations, with t 1/2 of 28.4 min and 8.67 min, repsectively. GAT211 limits dopamine D2 receptor-mediated extracellular regulated kinase (ERK) phosphorylation in Neuro2a cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo GAT211 potentiates the inhibition of electrically evoked vas deferens contraction in the same system (EC 50 =11 nM, E max =70). GAT211 (0.3 mg/kg, 1 mg/kg, 3 mg/kg; 5 mL/kg; ip; 2 doses with 5 min interval) dose-dependently reduced locomotor activity and the acoustic startle response.GAT211 is dissolved in a vehicle of ethanol, kolliphor, and saline at a ratio of 1:1:6 and injected at a volume of 5 mL/kg. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CB1
纯度	≥99%

关联靶点（人）

CNR1 Tclin 大麻素受体 1(Cannabinoid receptor 1) (3 活性数据)

点击查看靶蛋白信息： CNR1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

CNR1 Tclin Cannabinoid CB1 receptor (20913 活性数据)

点击查看靶蛋白信息： CNR1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

分子类型	未知
IIUPAC Name	3-(2-nitro-1-phenylethyl)-2-phenyl-1H-indole
INCHI	1S/C22H18N2O2/c25-24(26)15-19(16-9-3-1-4-10-16)21-18-13-7-8-14-20(18)23-22(21)17-11-5-2-6-12-17/h1-14,19,23H,15H2
InChi Key	OHZDCJJHWPHZJD-UHFFFAOYSA-N
Smiles	C1=CC=C(C=C1)C2=C(C3=CC=CC=C3N2)C(C[N+](=O)[O-])C4=CC=CC=C4
Isomeric SMILES	C1=CC=C(C=C1)C2=C(C3=CC=CC=C3N2)C(C[N+](=O)[O-])C4=CC=CC=C4
PubChem CID	4402318
分子量	342.39

化学和物理性质

溶解性	DMSO : 100 mg/mL (292.06 mM; Need ultrasonic)
分子量	342.400 g/mol
XLogP3	5.200
氢键供体数Hydrogen Bond Donor Count	1
氢键受体数Hydrogen Bond Acceptor Count	2
可旋转键计数Rotatable Bond Count	4
精确质量Exact Mass	342.137 Da
单同位素质量Monoisotopic Mass	342.137 Da
拓扑极表面积Topological Polar Surface Area	61.600 Å²
重原子数Heavy Atom Count	26
形式电荷Formal Charge	0
复杂度Complexity	465.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	1
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1