格尔德霉素现成溶液, 热休克蛋白 90 alpha 家族 B 类成员 1 抑制剂

级别和纯度:

Moligand™

有货

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
G466083-1ml	1ml	期货

查看相关系列

Amino Acid/Protein Metabolism (4559) Anti-infection (2804) Antibiotic (2632) Bacterial (5911) Cell Cycle/DNA Damage (2603) DNA Damage (3514) HSP (136) Influenza Virus (253) Metabolic Enzyme/Protease (4889) Virus (3767)

基本描述

英文别名	[(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate \| CCG-208040 \| HMS1362E15 \| [(3S,5S,6R,7S,8E,10R,11S,12Z,14E)-6-Hydroxy-5,11,21-trime
规格或纯度	Moligand™, 1mg/mL,来自吸水链霉菌
英文名称	Geldanamycin Ready Made Solution
储存温度	避光
作用类型	抑制剂
作用机制	热休克蛋白 90 alpha 家族 B 类成员 1 抑制剂
产品介绍	Description Chemical structure: benzenoidGeldanamycin Ready-Made Solution has been used as a heat shock protein 90 (Hsp90) inhibitor to pre-treat proteosome holo-enzyme during proteasome assay to study the role of proteasome on fibril fragmentation.

TRAP1 Tchem 热休克蛋白 75 kDa，线粒体(Heat shock protein 75 kDa, mitochondrial) (1 活性数据)

点击查看靶蛋白信息： TRAP1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

HSP90AA1 Tchem 热休克蛋白 HSP 90-alpha(Heat shock protein HSP 90-alpha) (20 活性数据)

点击查看靶蛋白信息： HSP90AA1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

HSP90AB1 Tchem 热休克蛋白 HSP 90-beta(Heat shock protein HSP 90-beta) (8 活性数据)

点击查看靶蛋白信息： HSP90AB1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

EC号	805-356-8
分子类型	小分子
IIUPAC Name	[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
INCHI	1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
InChi Key	QTQAWLPCGQOSGP-KSRBKZBZSA-N
Smiles	CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC
Isomeric SMILES	C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)/C)OC)OC(=O)N)\C)C)O)OC
关联CAS	30562-34-6
MeSH Entry Terms	geldanamycin;geldanomycin
分子量	560.64
Reaxy-Rn	26145919
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26145919&ln=

熔点	255°C
分子量	560.600 g/mol
XLogP3	2.000
氢键供体数Hydrogen Bond Donor Count	3
氢键受体数Hydrogen Bond Acceptor Count	9
可旋转键计数Rotatable Bond Count	5
精确质量Exact Mass	560.273 Da
单同位素质量Monoisotopic Mass	560.273 Da
拓扑极表面积Topological Polar Surface Area	163.000 Å²
重原子数Heavy Atom Count	40
形式电荷Formal Charge	0
复杂度Complexity	1150.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	6
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	3
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	3
共价键合单元计数Covalently-Bonded Unit Count	1

WGK Germany	2
RTECS	LX8920000
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

1. Rachel Cliffe, Jason C Sang, Franziska Kundel, Daniel Finley, David Klenerman, Yu Ye,. (2019-02-21) Filamentous Aggregates Are Fragmented by the Proteasome Holoenzyme.. Cell reports, 26 ((8)): ( 2140-2149 ). [PMID:30784595]
2. Xu Yao, Jie Zhu, Lin Li, Bo Yang, Bixia Chen, Endong Bao, Xiaohui Zhang. (2023) Hsp90 protected chicken primary myocardial cells from heat-stress injury by inhibiting oxidative stress and calcium overload in mitochondria. BIOCHEMICAL PHARMACOLOGY, 209 (115434). [PMID:36708886] [10.1016/j.bcp.2023.115434]
3. Yuanyuan Zhu, Yanyan Huang, Tian-Hao Yan, Jialuo Li, Yongming Li, Hannah F. Drake, Huifei Zhong, Yulong Jin, Rui Zhao, Hong-Cai Zhou. (2022) Metal-Organic Framework-Based Nanoheater with Photo-Triggered Cascade Effects for On-Demand Suppression of Cellular Thermoresistance and Synergistic Cancer Therapy. Advanced Healthcare Materials, 11 (13): (2200004). [PMID:35306753] [10.1002/adhm.202200004]