基本描述

别名	亚氨基脲盐酸盐, 亚氨脲盐酸盐, 盐酸胍
英文别名	Aminoformamidine HCl \| Chloride, Guanidium \| G0162 \| Guanidine hydrochloride, for molecular biology, >=99% \| Pharmakon1600-01300022 \| Aminoformamidine hydrochloride, Aminomethanamidine hydrochloride, Guanidinium chloride \| FT-0626822 \| Guanidine Hydrochlo
规格或纯度	≥99%(T), organic base and chaeotropic agent
英文名称	Guanidine hydrochloride
生化机理	盐酸胍(GdnHCl)是具有吸湿性的小分子。它是强效酶变性剂，可导致酶构象变化，从而导致酶活性完全丧失。GdnHCl参与体内阻断热休克蛋白104（Hsp104）腺苷三磷酸酶（ATPase）的活性。它参与杂色鲍鱼体内的碱性磷酸酶（ALPase）变性。GdnHCl可导致木瓜蛋白酶和氨酰酶等酶失活。较高浓度下的GdnHCl可有效灭活病毒，例如单纯疱疹病毒1（HSV-1）。
备注	注意: 在储存过程中可能会结块。产品的质量似乎并没有受到影响，而且由自由流动和块状的盐酸胍制备的溶液似乎是一样的。对于松散材料，请查看我们的Redi-Dri ™ 松散产品货号RDD001。
产品介绍	应用盐酸胍(GdnHCl)已用于：绝对定量血浆中的淀粉样β(Aß)亚型蛋白羰基化分析定量糖胺聚糖(GAG) 变性牛奶过敏原用作柯萨奇病毒B3（CVB3）的抗病毒筛选检测对照物 RNA分离，解离核蛋白并抑制RNase 强效离液剂，用于蛋白质的变性以及后续复性。该强效变性剂可溶解不溶性或变性的蛋白质，如包涵体。可用作使蛋白质或酶复性为活性形式的第一步骤。可能还需要脲和二硫苏糖醇 (DTT)。制备说明如需在水中制备8M的溶液，必须将溶液加热至35 °C后保持约30分钟。室温下盐酸胍在水中的最大溶解度约为6M。 Gene Information human ... KCNA1(3736), KCNA10(3744), KCNA2(3737), KCNA3(3738), KCNA4(3739), KCNA5(3741), KCNA6(3742), KCNA7(3743), KCNB1(3745), KCNB2(9312), KCNC1(3746), KCNC2(3747), KCNC3(3748), KCNC4(3749), KCND1(3750), KCND2(3751), KCND3(3752), KCNF1(3754), KCNG1(3755 Application Guanidine hydrochloride (GdnHCl) has been used: to perform absolute quantitation of amyloid-beta (Aß) isoforms in plasma in protein carbonylation assay for the quantification of glycosaminoglycans (GAG) for denaturation of cow′s milk allergens as a control in antiviral screening tests with coxsackievirus B3 (CVB3) in RNA isolation to dissociate nucleoproteins and inhibit RNase Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.
纯度	≥99%(T)

关联靶点（人）

LDHB Tchem L-lactate dehydrogenase B chain (463 活性数据)

点击查看靶蛋白信息： LDHB

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

C5 Tclin Complement C5 (49 活性数据)

点击查看靶蛋白信息： C5

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Coxsackievirus B3 (1096 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 活性数据)

点击查看靶蛋白信息： rep

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

EC号	200-002-3
分子类型	小分子
IIUPAC Name	guanidine;hydrochloride
INCHI	1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H
InChi Key	PJJJBBJSCAKJQF-UHFFFAOYSA-N
Smiles	C(=N)(N)N.Cl
Isomeric SMILES	C(=N)(N)N.Cl
分子量	95.53
Beilstein号	3591990
Reaxy-Rn	3591990
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3591990&ln=

化学和物理性质

溶解性	水：6M
密度	1.3g/cm3(lit.)
熔点	178-185°C
分子量	95.530 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count	4
氢键受体数Hydrogen Bond Acceptor Count	1
可旋转键计数Rotatable Bond Count	0
精确质量Exact Mass	95.025 Da
单同位素质量Monoisotopic Mass	95.025 Da
拓扑极表面积Topological Polar Surface Area	75.900 Å²
重原子数Heavy Atom Count	5
形式电荷Formal Charge	0
复杂度Complexity	26.300
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	2

安全和危险性（GHS）

象形图	GHS07
信号词	警告
危险声明	H302: 吞食有害 H315: 引起皮肤刺激 H319: 引起严重眼睛刺激
预防措施声明	P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P302+P352: 如皮肤沾染：用水充分清洗。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。
WGK Germany	1
RTECS	MF4300000
Merck Index	4562
个人防护装备	dust mask type N95 (US),Eyeshields,Faceshields,Gloves

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批号(Lot Number)	证书类型	货号
E23301352	分析证书	G432765
E23301272	分析证书	G432765
E23301274	分析证书	G432765
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此产品的引用文献

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引用文献

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溶液计算器

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计算溶液所需的质量、体积或浓度。

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计算配制储备溶液所需的稀释度。

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复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

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所需的复溶浓度

货号 (SKU)	包装规格	是否现货
G432765-25g	25g	现货
G432765-100g	100g	现货
G432765-500g	500g	现货
G432765-1kg	1kg	现货
G432765-2kg	2kg	期货
G432765-10kg	10kg	现货
G432765-25kg	25kg	现货

盐酸胍盐酸盐

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引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

盐酸胍 盐酸盐

库存信息

库存信息

库存信息

库存信息

库存信息

库存信息

库存信息

基本描述

关联靶点（人）

关联靶点（其它种属）

作用机制

名称和识别符

化学和物理性质

安全和危险性（GHS）

质检证书（CoA,COO,BSE/TSE 和分析图谱)

此产品的引用文献

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

盐酸胍盐酸盐