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甘氨鹅脱氧胆酸, ABCB11
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| G425251-1ml |
1ml |
现货  |
|
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基本描述
| 英文别名 | [(3alpha,7alpha-dihydroxy-24-oxo-5beta-cholan-24-yl)amino]acetic acid | 451ZNJ667Y | ST 24:1;O3;G | DTXSID301020165 | GLYCINE, N-((3.ALPHA.,5.BETA.,7.ALPHA.)-3,7-DIHYDROXY-24-OXOCHOLAN-24-YL)- | Glycylchenodeoxycholic acid | Chenodeoxyglycocholate | Cheno |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Glycochenodeoxycholic acid |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用机制 | ABCB11 |
关联靶点（人）
ABCB11
Tchem
胆盐输出泵(Bile salt export pump)
(1 活性数据)
NR1H4
Tclin
Bile acid receptor FXR
(6228 活性数据)
SLC10A2
Tclin
Ileal bile acid transporter
(415 活性数据)
GPBAR1
Tchem
G-protein coupled bile acid receptor 1
(1723 活性数据)
ABCB11
Tchem
Bile salt export pump
(2311 活性数据)
SLCO1B1
Tchem
Solute carrier organic anion transporter family member 1B1
(2672 活性数据)
SLCO1B3
Tchem
Solute carrier organic anion transporter family member 1B3
(2517 活性数据)
SLCO2B1
Tchem
Solute carrier organic anion transporter family member 2B1
(580 活性数据)
关联靶点（其它种属）
Slc10a1
Bile acid transporter (65 活性数据)
Slco1a1
Solute carrier organic anion transporter family member 1A1 (265 活性数据)
Slc10a2
Ileal sodium/bile acid cotransporter (17 活性数据)
Slco1a5
Solute carrier organic anion transporter family member 1A5 (48 活性数据)
Slco1a3
Solute carrier organic anion transporter family member 1A3 (65 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 2-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetic acid |
| INCHI | 1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 |
| InChi Key | GHCZAUBVMUEKKP-GYPHWSFCSA-N |
| Smiles | CC(CCC(=O)NCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C |
| Isomeric SMILES | C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C |
| 分子量 | 449.62 |
| Reaxy-Rn | 28775435 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=28775435&ln= |
化学和物理性质
| 分子量 | 449.600 g/mol |
|---|---|
| XLogP3 | 4.300 |
| 氢键供体数Hydrogen Bond Donor Count | 4 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 6 |
| 精确质量Exact Mass | 449.314 Da |
| 单同位素质量Monoisotopic Mass | 449.314 Da |
| 拓扑极表面积Topological Polar Surface Area | 107.000 Ų |
| 重原子数Heavy Atom Count | 32 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 727.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 10 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
引用文献
| 1. Wei Xu, Yingying Kong, Tuo Zhang, Zhihua Gong, Wenjun Xiao. (2022) L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 103 (3): (1283-1293). [PMID:36087337] [10.1002/jsfa.12222] |
| 2. Ma Wen, Yang Bingxin, Li Jun, Liu Mingxia, Li Xianjiang, Liu Huwei. (2022) Maltose-functional metal–organic framework assisted laser desorption/ionization mass spectrometry for small biomolecule determination. MICROCHIMICA ACTA, 189 (7): (1-8). [PMID:35689150] [10.1007/s00604-022-05338-x] |
| 3. Xiaoxu Cheng, Zifeng Pi, Zhong Zheng, Shu Liu, Fengrui Song, Zhiqiang Liu. (2022) Combined 16S rRNA gene sequencing and metabolomics to investigate the protective effects of Wu-tou decoction on rheumatoid arthritis in rats. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1199 (123249). [PMID:35447521] [10.1016/j.jchromb.2022.123249] |
| 4. Shun Zhang, Ting Cai, Jing Lin, Jia-Juan Liu, Yong-Gang Zhao, Min-Yi Cao. (2024) Analysis of 15 bile acids in human plasma based on C18 functionalized magnetic organic polymer nanocomposite coupled with liquid chromatography-tandem mass spectrometry. JOURNAL OF CHROMATOGRAPHY A, 1725 (464962). [PMID:38704923] [10.1016/j.chroma.2024.464962] |
| 5. Qian Fang, Xiaoying Hou, Limei Fan, Yufei Deng, Xiaoxuan Li, Hongyun Zhang, Haiping Wang, Zhengqi Fu, Binlian Sun, Xiji Shu, Hongzhi Du, Yuchen Liu. (2025) Gut microbiota derived DCA enhances FOLFOX efficacy via Ugt1a6b mediated enterohepatic circulation in colon cancer. PHARMACOLOGICAL RESEARCH, 213 (107636). [PMID:39894186] [10.1016/j.phrs.2025.107636] |
| 6. Huisheng Zhou, Xi Zhou, Guobin Huang, Yuanyuan Zhao, Peixiang Lan, Zhishui Chen. (2025) Inhibition of ferroptosis protects intrahepatic bile duct cells against ischemia–reperfusion and bile salt toxicity. BIOCHEMICAL PHARMACOLOGY, (116788). [PMID:39890033] [10.1016/j.bcp.2025.116788] |
| 7. Wen Ma, Mingxia Liu, Mengling Tu, Gang Wang, Jun Li, Fen Liu, Jian Yang, Xianjiang Li. (2024) Novel multi-layered MXene as laser desorption ionization mass spectrometry matrix for rapid detection of small biomolecules. CHEMICAL ENGINEERING JOURNAL, 500 (157466). [10.1016/j.cej.2024.157466] |