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(-)-没食子酸儿茶素没食子酸酯
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| G423917-1ml |
1ml |
现货  |
|
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基本描述
| 别名 | 没食子儿茶素没食子酸酯, GCG |
|---|---|
| 英文别名 | (-)-Gallocatechin 3-O-gallate | CCRIS 9286 | (-)-Gallocatechin gallate | Q27166763 | AKOS015901852 | NVP-XAA 225 | A844803 | (2S,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate | IRW3C4Y31Q | UNII-IRW3C4Y3 |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | (-)-Gallocatechin gallate |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 产品介绍 |
一种抗氧化剂 An antioxidant |
关联靶点（人）
PSMB5
Tclin
蛋白酶体亚基β5型(Proteasome subunit beta type-5)
(1 活性数据)
BCL2
Tclin
凋亡调节剂Bcl-2(Apoptosis regulator Bcl-2)
(1 活性数据)
MET
Tclin
Hepatocyte growth factor receptor
(10718 活性数据)
FASN
Tchem
Fatty acid synthase
(3390 活性数据)
HSP90AB1
Tchem
Heat shock protein HSP 90-beta
(1689 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
PGD
Tchem
6-phosphogluconate dehydrogenase
(58 活性数据)
DYRK1A
Tchem
Dual-specificity tyrosine-phosphorylation regulated kinase 1A
(6484 活性数据)
BCL2
Tclin
Apoptosis regulator Bcl-2
(3787 活性数据)
PSMB5
Tclin
Proteasome Macropain subunit MB1
(2451 活性数据)
G6PD
Tchem
Glucose-6-phosphate 1-dehydrogenase
(778 活性数据)
SNCA
Tchem
Alpha-synuclein
(10960 活性数据)
SIRT6
Tchem
NAD-dependent protein deacetylase sirtuin-6
(671 活性数据)
HMC1
(49 活性数据)
关联靶点（其它种属）
Plasmodium falciparum (966862 活性数据)
Human alphaherpesvirus 2 (4932 活性数据)
Rattus norvegicus (775804 活性数据)
Human alphaherpesvirus 1 (11089 活性数据)
Human immunodeficiency virus 1 (70413 活性数据)
Hepatitis C virus (23859 活性数据)
fabG
3-oxoacyl-acyl-carrier protein reductase (70 活性数据)
fabI
Enoyl-acyl-carrier protein reductase (415 活性数据)
Genome polyprotein (620 活性数据)
SARS-CoV-2 (38078 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | [(2S,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate |
| INCHI | 1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21+/m1/s1 |
| InChi Key | WMBWREPUVVBILR-NQIIRXRSSA-N |
| Smiles | C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
| Isomeric SMILES | C1[C@H]([C@@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
| 分子量 | 458.37 |
| Reaxy-Rn | 375093 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=375093&ln= |
化学和物理性质
| 敏感性 | 对光和湿度敏感 |
|---|---|
| 熔点 | 218 °C |
| 分子量 | 458.400 g/mol |
| XLogP3 | 1.200 |
| 氢键供体数Hydrogen Bond Donor Count | 8 |
| 氢键受体数Hydrogen Bond Acceptor Count | 11 |
| 可旋转键计数Rotatable Bond Count | 4 |
| 精确质量Exact Mass | 458.085 Da |
| 单同位素质量Monoisotopic Mass | 458.085 Da |
| 拓扑极表面积Topological Polar Surface Area | 197.000 Ų |
| 重原子数Heavy Atom Count | 33 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 667.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 2 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H302: 吞食有害 H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | DH9000000 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Gloves |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
引用文献
| 1. Yating Guo, Yili Shen, Boya Hu, Huichun Ye, Haowei Guo, Qiang Chu, Ping Chen. (2023) Decoding the Chemical Signatures and Sensory Profiles of Enshi Yulu: Insights from Diverse Tea Cultivars. Plants-Basel, 12 (21): (3707). [PMID:37960063] [10.3390/plants12213707] |
| 2. Ming-Xi Zhou, Xing Tian, Zhong-Qin Wu, Ke Li, Zong-Jun Li. (2021) Fuzhuan brick tea supplemented with areca nuts: Effects on serum and gut microbiota in mice. JOURNAL OF FOOD BIOCHEMISTRY, 45 (5): (e13737). [PMID:33876445] [10.1111/jfbc.13737] |
| 3. Yu-Meng Zhu, Jun-Jie Dong, Jing Jin, Jin-Hua Liu, Xin-Qiang Zheng, Jian-Liang Lu, Yue-Rong Liang, Jian-Hui Ye. (2021) Roasting process shaping the chemical profile of roasted green tea and the association with aroma features. FOOD CHEMISTRY, 353 (129428). [PMID:33714119] [10.1016/j.foodchem.2021.129428] |
| 4. Huanhuan Xu, Titi Liu, Jing Xu, Jin Li, Fei Chen, Zemin Xiang, Yewei Huang, Dongying Zhang, Lihong Hu, Banglei Zhang, Chengting Zi, Xuanjun Wang, Jun Sheng. (2019) Interactions between β-cyclodextrin and tea catechins, and potential anti-osteoclastogenesis activity of the (−)-epigallocatechin-3-gallate–β-cyclodextrin complex. RSC Advances, 9 (48): (28006-28018). [PMID:35558992] [10.1039/C9RA05889C] |
| 5. Meng Shi, Ying Nie, Xin-Qiang Zheng, Jian-Liang Lu, Yue-Rong Liang, Jian-Hui Ye. (2016) Ultraviolet B (UVB) Photosensitivities of Tea Catechins and the Relevant Chemical Conversions. MOLECULES, 21 (10): (1345). [PMID:27735869] [10.3390/molecules21101345] |
| 6. Fang-Yuan Fan, Meng Shi, Ying Nie, Yue Zhao, Jian-Hui Ye, Yue-Rong Liang. (2016) Differential behaviors of tea catechins under thermal processing: Formation of non-enzymatic oligomers. FOOD CHEMISTRY, 196 (347). [PMID:26593500] [10.1016/j.foodchem.2015.09.056] |
| 7. Liu, et al.. (2020) Rapid Screening ?-Glucosidase Inhibitors from Natural Products by At-Line Nanofractionation with Parallel Mass Spectrometry and Bioactivity Assessment.. Journal of Chromatography A, 1635 (461740-461740). [PMID:33271429] |
| 8. Songyan Huang, Lingling Tao, Linlin Xu, Mingtao Shu, Dahe Qiao, Huilin Wen, Hui Xie, Hongrong Chen, Shengrui Liu, Deyu Xie, Chaoling Wei, Junyan Zhu. (2024) Discrepancy on the flavor compound affect the quality of Taiping Houkui tea from different production regions. Food Chemistry-X, 23 (101547). [PMID:38974194] [10.1016/j.fochx.2024.101547] |
| 9. Zhenfeng Xie, Yi Wu. (2024) Enhancing (−)-epigallocatechin gallate thermal stability in emulsified oil droplets: Designing a thermal insulation interface for O/W emulsion. JOURNAL OF FOOD ENGINEERING, 375 (112065). [10.1016/j.jfoodeng.2024.112065] |
| 10. Yating Guo, Yani Pan, Xinyu Feng, Haowei Guo, Liping Liu, Kexin Zhang, Haojun Xie, Binkai Zhu, Shuying Gong, Qiang Chu, Hua Fang, Ping Chen. (2025) Reshaped local microbiology metabolism by raw tea according to pile fermentation in the dark tea. Journal of Advanced Research, [PMID:40064439] [10.1016/j.jare.2025.02.039] |
| 11. Haozhen Li, Shuyao Wang, Xiaohua Zhang, Kangkang Song, Long Yang. (2025) Revealing novel insights into the improvement of greenhouse tea quality through exogenous substance interventions using targeted and untargeted metabolomics and microbial community analyses. Food Chemistry-X, 27 (102410). [PMID:40213339] [10.1016/j.fochx.2025.102410] |