| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| G423611-1ml |
1ml |
现货  |
|
| 别名 | 加兰他敏 | 加兰他明 | 尼瓦林 | 强肌 | 雪花胺 | 雪花莲胺 | 加兰他敏 |
|---|---|
| 英文别名 | AKOS015965330 | KBio3_002636 | Lycoremin | NSC-100058 | Spectrum5_001673 | KBioSS_001751 | BDBM10404 | Galantaminum | NCGC00017256-17 | NSC 100058 | Galantamine | DB00674 | AC-20240 | CHEBI:42944 | GALANTAMINE [VANDF] | Galantaminum [INN-Latin] | Jilkon | |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Galanthamine |
| 生化机理 | 加兰他敏是一种选择性乙酰胆碱酯酶抑制剂，可阻断乙酰胆碱的分解，使受体被激活的时间更长。对丁酰胆碱酯酶的选择性超过 50 倍。抑制红细胞胆碱酯酶活性的效力是人脑组织的 10 倍。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 乙酰胆碱酯酶抑制剂（卡特赖特血型） |
| 产品介绍 |
Galanthamine是长效中枢活性乙酰胆碱酯酶（AChE）抑制剂，IC50为410 nM，同时是神经元烟碱乙酰胆碱受体的变构增强剂。 Galanthamine is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol |
| INCHI | 1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1 |
| InChi Key | ASUTZQLVASHGKV-JDFRZJQESA-N |
| Smiles | CN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)OC)O |
| Isomeric SMILES | CN1CC[C@@]23C=C[C@@H](C[C@@H]2OC4=C(C=CC(=C34)C1)OC)O |
| 分子量 | 287.35 |
| Reaxy-Rn | 625778 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=625778&ln= |
| 分子量 | 287.350 g/mol |
|---|---|
| XLogP3 | 1.800 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 1 |
| 精确质量Exact Mass | 287.152 Da |
| 单同位素质量Monoisotopic Mass | 287.152 Da |
| 拓扑极表面积Topological Polar Surface Area | 41.900 Ų |
| 重原子数Heavy Atom Count | 21 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 440.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 3 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS06, GHS07, GHS08, GHS09 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H301: 吞咽会中毒 H315: 引起皮肤刺激 H317: 可能引起皮肤过敏反应 H319: 引起严重眼睛刺激 H331: 吸入会中毒 H373: 通过长时间或反复暴露对器官造成损害 H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响 H301+H331: 吞咽或吸入可致中毒。 |
| 预防措施声明 |
P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P272: 被污染的工作服不允许离开工作场所 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P391: 收集溢出物 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P316: 立即寻求紧急医疗救助。 P319: 如果你感到不适，请寻求医疗帮助。 |
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