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小分子和化合物库
Genz-123346(free base)

Genz-123346(free base)

COA

级别和纯度:

≥95%

CAS编号: 491833-30-8
分子式: C₂₄H₃₈N₂O₄
分子量: 418.57
PubChem编号: 23652732
PubChem SID: 504769452

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货号 (SKU)	包装规格	是否现货
G413484-5mg	5mg	现货
G413484-10mg	10mg	现货
G413484-25mg	25mg	现货
G413484-50mg	50mg	现货
G413484-100mg	100mg	现货

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基本描述

别名	Genz-123346 游离碱
英文别名	Glucosylceramide Synthase Inhibitor \| Genz-123346 - CAS 491833-30-8 - Calbiochem \| (1R,2R)-nonanoic acid[2-(2ʹ,3ʹ-dihydro-benzo [1, 4] dioxin-6ʹ-yl)-2-hydroxy-1-pyrrolidin-1-ylmethyl-ethyl]-amide \| GL1 synthase Inhibitor \| Genz-123346 \| Genz123346
规格或纯度	≥95%
英文名称	Genz-123346 free base
储存温度	避光,-20°C储存
运输条件	超低温冰袋运输
作用类型	抑制剂
产品介绍	Genz-123346 (free base) is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1; inhibits GM1 with IC50 value of 14 nM. IC50: 14 nM (GM1) Exposure of cells to Genz-123346 and to other GCS inhibitors at nontoxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents. Genz-123346 and a few other GCS inhibitors are substrates for multi-drug resistance efflux pumps such as P-gp (ABCB1, gP-170). In cell lines selected to over-express P-gp or which endogenously express P-gp, chemosensitization by Genz-123346 is primarily due to the effects on P-gp function. Genz-123346(Genz) is an enhancer of autophagy flux. In the Zucker diabetic fatty rat, Genz-123346 loared glucose and A1C levels and improved glucose tolerance. Drug treatment also prevented the loss of pancreatic beta-cell function and preserved the ability of the animals to secrete insulin. In the diet-induced obese mouse, treatment with Genz-123346 normalized A1C levels and improved glucose tolerance. The oral bioavailability of the drug is shown to be about 10% and 30% in mice and rats, respectively, with a half-life in plasma of 30-60 min. Genz-123346 treatment results in a dose-dependent reduction of renal GlcCer and GM3 levels that translates into effective inhibition of cystic disease. A direct effect of Genz-123346 on the Akt-mTOR signaling pathway is observed, with reduced phosphorylation of Akt and ribosomal protein S6. Information Genz-123346 is an inhibitor ofGL1 synthasethat blocks the conversion of ceramide to GL1, the first step in the biosynthesis of gangliosides and other glycosphingolipids.
纯度	≥95%

产品属性

ALogP	4.264
hba_count	3
HBD Count	2
Rotatable Bond	12

关联靶点（人）

UGCG Tclin 神经酰胺葡萄糖基转移酶(Ceramide glucosyltransferase) (1 活性数据)

点击查看靶蛋白信息： UGCG

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

UGCG Tclin Ceramide glucosyltransferase (308 活性数据)

点击查看靶蛋白信息： UGCG

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Hdac6 Histone deacetylase 6 (222 活性数据)

点击查看靶蛋白信息： Hdac6

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 活性数据)

点击查看靶蛋白信息： rep

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	504769452
分子类型	小分子
Isomeric SMILES	CCCCCCCCC(=O)N[C@H](CN1CCCC1)[C@@H](C2=CC3=C(C=C2)OCCO3)O
分子量	418.57
Reaxy-Rn	20242348
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20242348&ln=

化学和物理性质

敏感性	对光敏感
DMSO(mg / mL) Max Solubility	84
DMSO(mM) Max Solubility	200.683278782521
Water(mg / mL) Max Solubility	＜1
分子量	418.600 g/mol
XLogP3	4.200
氢键供体数Hydrogen Bond Donor Count	2
氢键受体数Hydrogen Bond Acceptor Count	5
可旋转键计数Rotatable Bond Count	12
精确质量Exact Mass	418.283 Da
单同位素质量Monoisotopic Mass	418.283 Da
拓扑极表面积Topological Polar Surface Area	71.000 Å²
重原子数Heavy Atom Count	30
形式电荷Formal Charge	0
复杂度Complexity	498.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	2
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1