基本描述

别名	葡糖胺 \| 葡萄糖胺 \| D-氨基葡萄糖
英文别名	2-Amino-2-Deoxy-D-Glucopyranose \| BRN 1724602 \| N08U5BOQ1K \| 4-04-00-02017 (Beilstein Handbook Reference) \| DB01296 \| Glucosamine free base \| 2-Amino-2-Deoxy-D-Glucopyranoside \| D-Glucose, 2-amino-2-deoxy- \| methyl-3-(chlorosulfonyl)thiophene-2-carboxylat
规格或纯度	异构体混合物, ≥95%
英文名称	Glucosamine
生化机理	葡萄糖胺（2-氨基-2-脱氧-D-葡萄糖）是一种氨基糖，也是糖基化蛋白质和脂质生化合成的主要前体。它常用于治疗骨关节炎。葡萄糖胺（GS）通过干扰柠檬酸循环代谢产物的产生，在蛋白水平上选择性地下调 YD-8 细胞中的 HIF-1α。
储存温度	-20°C储存
运输条件	超低温冰袋运输
作用机制	补充剂
产品介绍	Information Glucosamine Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.
纯度	≥95%

产品属性

pKa值	pKₐ: 12.27 (Predicted), pKₐ: 8.44 (Predicted)

关联靶点（人）

F2 Tclin Thrombin (11687 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

ESR1 Tclin Estrogen receptor alpha (17718 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

PGR Tclin Progesterone receptor (8562 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)

点击查看靶蛋白信息： ADRA2A

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

AR Tclin Androgen Receptor (11781 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

MAOA Tclin Monoamine oxidase A (11911 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

DRD1 Tclin Dopamine D1 receptor (9720 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

ACHE Tclin Acetylcholinesterase (18204 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SLC6A4 Tclin Serotonin transporter (12625 活性数据)

点击查看靶蛋白信息： SLC6A4

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

OPRM1 Tclin Mu opioid receptor (19785 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

DRD3 Tclin Dopamine D3 receptor (14368 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SLC6A3 Tclin Dopamine transporter (10535 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

KCNH2 Tclin HERG (29587 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

PDE3A Tclin Phosphodiesterase 3A (3309 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

TBXA2R Tclin Thromboxane A2 receptor (5717 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

PDE4A Tclin Phosphodiesterase 4A (1943 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

ADORA3 Tchem Adenosine A3 receptor (15931 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

HRH3 Tclin Histamine H3 receptor (10389 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

KDR Tclin Vascular endothelial growth factor receptor 2 (20924 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

HT-1080 (3966 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

MG-63 (795 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

MDA-MB-231 (73002 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SLC22A1 Tchem Solute carrier family 22 member 1 (646 活性数据)

点击查看靶蛋白信息： SLC22A1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

FIBCD1 Tbio Fibrinogen C domain-containing protein 1 (33 活性数据)

点击查看靶蛋白信息： FIBCD1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Mmp2 Matrix metalloproteinase-2 (12 活性数据)

点击查看靶蛋白信息： Mmp2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Mmp9 Matrix metalloproteinase 9 (38 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

RAW (181 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

RAW264.7 (28094 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Cartilage (29 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Trametes versicolor (86 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Poria (18 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	504758692
分子类型	小分子
Isomeric SMILES	C([C@@H]1[C@H]([C@@H]([C@H](C(O1)O)N)O)O)O
分子量	179.17
Beilstein号	1423209
Reaxy-Rn	1423209
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1423209&ln=

化学和物理性质

溶解性	Solubility (25°C) In vitro Water: 36 mg/mL (200.92 mM); DMSO: 23 mg/mL (128.36 mM); Ethanol: Insoluble;
折光率	n20D1.6 (Predicted)
沸点	~449.9° C at 760 mmHg (Predicted)
熔点	109-111° C
分子量	179.170 g/mol
XLogP3	-2.800
氢键供体数Hydrogen Bond Donor Count	5
氢键受体数Hydrogen Bond Acceptor Count	6
可旋转键计数Rotatable Bond Count	1
精确质量Exact Mass	179.079 Da
单同位素质量Monoisotopic Mass	179.079 Da
拓扑极表面积Topological Polar Surface Area	116.000 Å²
重原子数Heavy Atom Count	12
形式电荷Formal Charge	0
复杂度Complexity	155.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	4
未定义的原子立体中心计数Undefined Atom Stereocenter Count	1
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

信号词	警告
危险声明	H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
RTECS	LZ6665000

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批号(Lot Number)	证书类型	货号
H2504305	分析证书	G413437
H2504306	分析证书	G413437
H2504307	分析证书	G413437
H2504308	分析证书	G413437
H2504309	分析证书	G413437
E2515039	分析证书	G413437
B2506081	分析证书	G413437
F2427312	分析证书	G413437
F2427313	分析证书	G413437
F2427326	分析证书	G413437
F2427327	分析证书	G413437
F2427328	分析证书	G413437
H2303586	分析证书	G413437
H2303589	分析证书	G413437
H2303591	分析证书	G413437
H2303598	分析证书	G413437
H2303599	分析证书	G413437
H2303602	分析证书	G413437
H2303603	分析证书	G413437
H2303613	分析证书	G413437
H2303623	分析证书	G413437
H2303634	分析证书	G413437
C2426057	分析证书	G413437
C2426058	分析证书	G413437
D2318896	分析证书	G413437
D2318913	分析证书	G413437

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引用文献

1. Shuwei Yuan, Miaomiao Zhang, Zhen Yao, Jiangyun Liu, Xiang Li, Zhenqing Zhang, Duxin Li. (2024) Isolation, structural characterization, and bioactivities of neutral polysaccharides from Zizania latifolia. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 254 (127679). [PMID:37890741] [10.1016/j.ijbiomac.2023.127679]
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3. Yang Liu, Limei Ran, Yahong Wang, Peng Wan, Hongli Zhou. (2023) Basic characterization, antioxidant and immunomodulatory activities of polysaccharides from sea buckthorn leaves. FITOTERAPIA, 169 (105592). [PMID:37343686] [10.1016/j.fitote.2023.105592]
4. Shuwei Yuan, Jiahui Wang, Xiang Li, Xun Zhu, Zhenqing Zhang, Duxin Li. (2023) Study on the structure, antioxidant activity and degradation pattern of polysaccharides isolated from lotus seedpod. CARBOHYDRATE POLYMERS, 316 (121065). [PMID:37321745] [10.1016/j.carbpol.2023.121065]
5. Cui Cao, Lilong Wang, Xueqian Zhang, Chunqing Ai, Zhongfu Wang, Linjuan Huang, Shuang Song, Beiwei Zhu. (2023) Interaction between Bacteroidetes species in the fermentation of Lycium barbarum arabinogalactan. FOOD CHEMISTRY, 409 (135288). [PMID:36584527] [10.1016/j.foodchem.2022.135288]
6. Zhengyu Hu, Jiaming Wang, Long Jin, Tieqiang Zong, Yuanqi Duan, Jinfeng Sun, Wei Zhou, Gao Li. (2022) Preparation, Characterization and Anti-Complementary Activity of Three Novel Polysaccharides from Cordyceps militaris. Polymers, 14 (21): (4636). [PMID:36365633] [10.3390/polym14214636]
7. Dongxue Cao, Enwei Wei, Zeyu Wang, Zhengyu Hu, Ling Qi, Hongli Zhou, Jingli Zhao. (2022) Microwave-assisted extraction, structural elucidation, and in vitro anti-glioma and immunostimulatory activity of polysaccharide from Panax ginseng C. A. Meyer. INDUSTRIAL CROPS AND PRODUCTS, 189 (115729). [10.1016/j.indcrop.2022.115729]
8. Jinfang Zhang, Baoyue Zhu, Xiaojian Xu, Yihan Liu, Qinggang Li, Yu Li, Fuping Lu. (2022) Remodeling Bacillus amyloliquefaciens Cell Wall Rigidity to Reduce Cell Lysis and Increase the Yield of Heterologous Proteins. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (34): (10552–10562). [PMID:35984403] [10.1021/acs.jafc.2c04454]
9. Zhengyu Hu, Ruiying Yu, Jinfeng Sun, Yuanqi Duan, Hongli Zhou, Wei Zhou, Gao Li. (2022) Static decolorization of polysaccharides from the leaves of Rhododendron dauricum: Process optimization, characterization and antioxidant activities. PROCESS BIOCHEMISTRY, 121 (113). [10.1016/j.procbio.2022.06.025]
10. Lei Li, Yun Fang, Yongmei Xia, Chunling Bo, Ye Fan. (2022) Monosaccharides driving the formation of conjugated linoleic acid vesicles in near-neutral solutions via weak noncovalent bonding interactions. JOURNAL OF MOLECULAR LIQUIDS, 351 (118656). [10.1016/j.molliq.2022.118656]
11. Hualing Xie, Jingyu Fang, Mohamed A. Farag, Zhenhao Li, Peilong Sun, Ping Shao. (2022) Dendrobium officinale leaf polysaccharides regulation of immune response and gut microbiota composition in cyclophosphamide-treated mice. Food Chemistry-X, 13 (100235). [PMID:35499019] [10.1016/j.fochx.2022.100235]
12. Yilin Zhang, Mengqi Wu, Jingrui Xi, Chen Pan, Zhizhen Xu, Wei Xia, Wenqing Zhang. (2021) Multiple-fingerprint analysis of Poria cocos polysaccharide by HPLC combined with chemometrics methods. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 198 (114012). [PMID:33713882] [10.1016/j.jpba.2021.114012]
13. Xiaoguo Ji, Mai Chen, Mengyao Zhao, Yudong Song, Yong Lin, Hao Yin, Liming Zhao. (2021) Effects of chitooligosaccharides on the rebalance of gut microorganisms and their metabolites in patients with nonalcoholic fatty liver disease. Journal of Functional Foods, 77 (104333). [10.1016/j.jff.2020.104333]
14. Yuhuan Ma, Wenwei Zheng, Houhuang Chen, Xiang Shao, Pingdong Lin, Xianxiang Liu, Xihai Li, Hongzhi Ye. (2018) Glucosamine promotes chondrocyte proliferation via the Wnt/β‑catenin signaling pathway. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 42 (1): (61-70). [PMID:29568900] [10.3892/ijmm.2018.3587]
15. Li Guo, Shan Huang, Jinqing Qu. (2018) Synthesis and properties of high-functionality hydroxyl-terminated polyurethane dispersions. PROGRESS IN ORGANIC COATINGS, 119 (214). [10.1016/j.porgcoat.2018.02.033]
16. Hongyan Zhu, Wanwan Liu, Ziting Cheng, Ke Yao, Yu Yang, Bohui Xu, Gaoxing Su. (2017) Targeted Delivery of siRNA with pH-Responsive Hybrid Gold Nanostars for Cancer Treatment. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18 (10): (2029). [PMID:28937584] [10.3390/ijms18102029]
17. Jianbing Zhu, Meiling Xiao, Kui Li, Changpeng Liu, Xiao Zhao, Wei Xing. (2016) Active Pt3Ni (111) Surface of Pt3Ni Icosahedron for Oxygen Reduction. ACS Applied Materials & Interfaces, 8 (44): (30066–30071). [PMID:27735187] [10.1021/acsami.6b04237]
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19. Zhen Yao, Kehan Zhu, Tianyi Gu, Oliver J. Schmitz, Duxin Li. (2024) An active derivatization detection method for inline monitoring the isolation of carbohydrates by preparative liquid chromatography. JOURNAL OF CHROMATOGRAPHY A, (464730). [PMID:38367394] [10.1016/j.chroma.2024.464730]
20. Liying Hao, Jikui Sun, Qingyin Wang, Haijiao Xie, Xiangui Yang, Qiang Wei. (2024) Application of Mesoporous Carbon-Based Highly Dispersed K–O2 Strong Lewis Base in the Efficient Catalysis of Methanol and Ethylene Carbonate. ACS Applied Materials & Interfaces, 16 (32): (42080-42092). [PMID:39078413] [10.1021/acsami.4c05587]
21. Juncheng Liu, Xingyu Lu, Fang Fang, Kaizhang Wu, Jihong Wu, Jie Gao. (2024) Comparison of the in-vitro effect of five prebiotics with different structure on gut microbiome and metabolome. Food Bioscience, (103810). [10.1016/j.fbio.2024.103810]
22. He Li, Changxin Zheng, Yanru Zheng, Kai Wen, Yingjiu Zhang. (2024) Distinct functional diversity of branched oligosaccharides as chaperones and inhibitory-binding partners of amyloid beta-protein and its aggregates. NEUROPHARMACOLOGY, (110141). [PMID:39251087] [10.1016/j.neuropharm.2024.110141]
23. Yuanqi Duan, Zhengyu Hu, Long Jin, Tieqiang Zong, Xiaohui Zhang, Yanan Liu, Pengcheng Yang, Jinfeng Sun, Wei Zhou, Gao Li. (2024) Efficient degradation and enhanced anticomplementary activity of Belamcanda chinensis (L.) DC. polysaccharides via trifluoroacetic acid treatment with different degrees. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, (134117). [PMID:39084989] [10.1016/j.ijbiomac.2024.134117]
24. Xiaohui Zhang, Zhengyu Hu, Yuanqi Duan, Yuxin Jiang, Weiwei Xu, Pengcheng Yang, Wei Zhou, Jinfeng Sun, Gao Li. (2024) Extraction, characterization, and neuroprotective effects of polysaccharides the stems of Panax ginseng C. A. Meyer by three different solvents (water, acid, alkali). INDUSTRIAL CROPS AND PRODUCTS, 222 (119512). [10.1016/j.indcrop.2024.119512]
25. Weiwei Xu, Wei Zhou, Jinfeng Sun, Weiwei Chen, Xuanye Wu, Tong Guan, Yilin Zhao, Pengcheng Yang, Zhengyu Hu, Gao Li. (2024) Isolation, structural characterization, and hypoglycemic activity of polysaccharides from the stems of Panax ginseng C. A. Meyer. Frontiers in Sustainable Food Systems, 8 [10.3389/fsufs.2024.1500278]
26. Qijun Yu, Jinshui Yang, Liang Liu, Yaru Huang, Entao Wang, Dongmei Li, Hongli Yuan. (2025) One-step immobilization of chitosanase on microcrystalline cellulose using a carbohydrate binding module family 2. CARBOHYDRATE POLYMERS, 353 (123291). [PMID:39914986] [10.1016/j.carbpol.2025.123291]
27. Menghan Yuan, Xinyue Huang, Shuang Tian, Shixuan Ma, Yuxing Guo, Mingxuan Tao. (2024) Selenized modification and structural characterization of Pleurotus eryngii polysaccharides and their immunomodulatory activity. PROCESS BIOCHEMISTRY, 144 (97). [10.1016/j.procbio.2024.05.018]
28. Wenli Lei, Shuang Zhang, Jiaxi Shu, Fudong Li, Zixuan Deng, Juejing Liu, Xiaofeng Guo, Yuanmeng Zhao, Changsheng Shan. (2025) Self-Powered Glucose Biosensor Based on Non-Enzymatic Biofuel Cells by Au Nanocluster/Pd Nanocube Heterostructure and Fe3C@C-Fe Single-Atom Catalyst. Small, (2410326). [PMID:39981798] [10.1002/smll.202410326]
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溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

货号 (SKU)	包装规格	是否现货
G413437-5mg	5mg	现货
G413437-25mg	25mg	现货
G413437-100mg	100mg	现货
G413437-250mg	250mg	现货
G413437-1g	1g	现货

氨基葡萄糖, 补充剂

库存信息

库存信息

库存信息

库存信息

库存信息

基本描述

产品属性

关联靶点（人）

关联靶点（其它种属）

作用机制

名称和识别符

化学和物理性质

安全和危险性（GHS）

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器