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吉非替尼 (ZD1839), 表皮生长因子受体 erbB1 抑制剂

选择性EGFR酪氨酸激酶抑制剂
33篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
G125799-50mg
 50mg 现货 Stock Image
G125799-250mg
 250mg 现货 Stock Image
G125799-1g
 1g 现货 Stock Image
G125799-5g
 5g 现货 Stock Image
G125799-10g
 10g 现货 Stock Image
G125799-25g
 25g 现货 Stock Image
G125799-100g
 100g 期货 Stock Image
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基本描述

别名 吉非替尼
英文别名 ZD 1839 | AM20090619 | Gefitinib [USAN:INN:BAN] | SY017890 | CHEBI:49668 | nchembio866-comp14 | 4-(3'-Chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline | 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)prop
规格或纯度 Moligand™, ≥99%
英文名称 Gefitinib (ZD1839)
生化机理 吉非替尼是一种表皮生长因子受体（EGFR）-酪氨酸激酶抑制剂，已被证明能增加 HaCaT 细胞中 c-Jun NH2 端激酶（JNK）和 p38 丝裂原活化蛋白激酶（MAPK）的磷酸化。研究表明，吉非替尼可以通过不依赖于表皮生长因子受体的 JNK 激活途径促进角朊细胞凋亡。研究表明，吉非替尼能诱导多种细胞系凋亡，包括 HaCaT 细胞、KG-1 细胞、P39 细胞和原代 CD34+ 骨髓母细胞。口服活性、强效、选择性表皮生长因子受体（EGFR）酪氨酸激酶抑制剂（IC 50 = 33 nM）。抑制表皮生长因子受体刺激的表皮生长因子受体自身磷酸化，抑制体内肿瘤生长。增强细胞毒性药物的疗效。
储存温度 2-8°C储存
运输条件 冰袋运输
作用类型 抑制剂
作用机制 表皮生长因子受体 erbB1 抑制剂
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

Gefitinib (ZD1839)是一种EGFR抑制剂，作用于NR6wtEGFR和NR6W细胞中的Tyr1173，Tyr992，Tyr1173和Tyr992，IC50 分别为37 nM，37nM，26 nM和57 nM。An EGFR-tyrosine kinase inhibitor

Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.
An EGFR-tyrosine kinase inhibitor
纯度 ≥99%

产品属性

ALogP 4.1

关联靶点（人）

ERBB2 Tclin 受体酪氨酸蛋白激酶 erbB-2(Receptor tyrosine-protein kinase erbB-2) (3 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
EGFR Tclin 表皮生长因子受体(Epidermal growth factor receptor) (128 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
GAK Tchem 细胞周期蛋白G相关激酶(Cyclin-G-associated kinase) (7 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
RELA Tchem 转录因子 p65(Transcription factor p65) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
RIPK2 Tchem 受体相互作用丝氨酸/苏氨酸蛋白激酶 2(Receptor-interacting serine/threonine-protein kinase 2) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
ABCG2 Tchem ATP 结合盒亚家族 G 成员 2(ATP-binding cassette sub-family G member 2) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
ABL1 Tclin Tyrosine-protein kinase ABL (18331 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
INSR Tclin Insulin receptor (5558 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TOP2A Tclin DNA topoisomerase II alpha (6317 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
VDR Tclin Vitamin D receptor (26531 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
IMPDH2 Tclin Inosine-5'-monophosphate dehydrogenase 2 (1326 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDGFRB Tclin Platelet-derived growth factor receptor beta (5195 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2B Tclin Alpha-2b adrenergic receptor (4412 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2C Tclin Alpha-2c adrenergic receptor (4876 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
IGF1R Tclin Insulin-like growth factor I receptor (8605 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KIT Tclin Stem cell growth factor receptor (10667 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Cdk4 Cyclin-dependent kinase 4 (3 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cruzipain (33337 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cckar Cholecystokinin A receptor (90 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PIK3CA PI3-kinase p110-alpha subunit (51 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pde4d Phosphodiesterase 4D (4 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pygl Liver glycogen phosphorylase (81 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Prkcd Protein kinase C delta (192 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Prkcb Protein kinase C beta (2 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Abcb1b P-glycoprotein 1 (174 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hdac1 Histone deacetylase 1 (93 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Fgfr4 Fibroblast growth factor receptor 4 (138 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Camk2g CaM kinase II gamma (1 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HD1 Histone deacetylase (38 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Tec Tyrosine-protein kinase TEC (25 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ulk3 ULK3 kinase (23 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mycobacterium tuberculosis (203094 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Saccharomyces cerevisiae (19171 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Toxoplasma gondii (4585 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Vaccinia virus (4609 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BaF3 (4657 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHO-K1 (1115 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MDCK (10148 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Vero (26788 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ehrlich (1318 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
H4 (48 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NIH3T3 (5395 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
L929 (3802 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Lewis lung carcinoma cell line (1243 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
B16-F10 (4610 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AIRC Multifunctional protein ADE2 (8 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
norA Quinolone resistance protein norA (2171 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Brain (1 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Blood (6 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasma (328 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cerebrospinal fluid (288 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
pknB Serine/threonine-protein kinase pknB (356 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CDPK1 Calcium-dependent protein kinase 1 (793 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CRK2 Cell division control protein 2 homolog (194 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Septin9 Septin-9 (1 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Acadvl Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (1 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504756948
分子类型 小分子
IIUPAC Name N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
INCHI 1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
InChi Key XGALLCVXEZPNRQ-UHFFFAOYSA-N
Smiles COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
Isomeric SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
分子量 446.9
Reaxy-Rn 8949523
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8949523&ln=

化学和物理性质

溶解性 Soluble in DMSO (89 mg/ml at 25 °C), methanol (20 mg/ml), ethanol (4 mg/ml at 25 °C), DMF (20 mg/ml), and water (<1 mg/ml at 25 °C).
敏感性 对热敏感
比旋光度 1.62
沸点 586.8 °C
熔点 194.0 to 198.0 °C
分子量 446.900 g/mol
XLogP3 4.100
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 8
可旋转键计数Rotatable Bond Count 8
精确质量Exact Mass 446.152 Da
单同位素质量Monoisotopic Mass 446.152 Da
拓扑极表面积Topological Polar Surface Area 68.700 Ų
重原子数Heavy Atom Count 31
形式电荷Formal Charge 0
复杂度Complexity 545.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS05,   GHS07,   GHS08,   GHS09
信号词 危险
危险声明

H302: 吞食有害

H315: 引起皮肤刺激

H318: 造成严重的眼睛损伤

H351: 怀疑引起遗传缺陷

H361: 怀疑破坏生育力或未出生的孩子

H373: 通过长时间或反复暴露对器官造成损害

H400: 对水生生物有剧毒

H411: 对水生生物有毒并具有长期持续影响
预防措施声明

P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。

P264: 处理后要彻底洗手。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P273: 避免释放到环境中。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P321: 特殊处理（请参阅此标签上的...）。

P330: 漱口

P391: 收集溢出物

P302+P352: 如皮肤沾染：用水充分清洗。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P203: 使用前，获取、阅读并遵守所有安全说明。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P301+P317: 如果被吞咽：请寻求医疗帮助。

P305+P354+P338: 如果进入眼睛：立即用水冲洗几分钟。取下隐形眼镜（如果有的话），并且操作简单。继续冲洗。

P318: 如果暴露或担心，请就医。

P317: 寻求紧急医疗救助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。

P319: 如果你感到不适，请寻求医疗帮助。

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L2312045 分析证书 G125799
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H2311045 分析证书 G125799
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B2526010 分析证书 G125799
C2526059 分析证书 G125799
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K2112570 分析证书 G125799
K1506042 分析证书 G125799
F1910168 分析证书 G125799
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引用文献

1. Wakeling AE, Guy SP, Woodburn JR, Ashton SE, Curry BJ, Barker AJ, Gibson KH.  (2002)  ZD1839 (Iressa): an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy..  Cancer Res,  62  (20): (5749-54).  [PMID:12384534]
2. Gan CJ et al..  (2020)  EGF receptor inhibitors comprehensively suppress hepatitis B virus by downregulation of STAT3 phosphorylation..  Biochem Biophys Rep,  22  (100763).  [PMID:32322693]
3. Yan J et al..  (2020)  GOLM1 upregulates expression of PD-L1 through EGFR/STAT3 pathway in hepatocellular carcinoma..  Am J Cancer Res,  10  (11): (3705-3720).  [PMID:33294262]
4. Devaraj V & Bose B.  (2019)  Morphological State Transition Dynamics in EGF-Induced Epithelial to Mesenchymal Transition..  J Clin Med,  8  (7): [PMID:31247884]
5. Jiali Wang, Xianhai He, Zhirong Jia, Aiwen Yan, Kang Xiao, Shuo Liu, Mengjun Hou, Yaling Long & Xuansheng Ding.  (2023)  Shenqi Fuzheng injection restores the sensitivity to gefitinib in non-small cell lung cancer by inhibiting the IL-22/STAT3/AKT pathway.  Pharmaceutical Biology,  1  (61): (33-41).  [PMID:38100532] [10.1080/13880209.2023.2292266]
6. Yong Huang, Yi Lin, Bowen Li, Fu Zhang, Chenyue Zhan, Xin Xie, Zhuo Yao, Chongzhi Wu, Yuan Ping, Jianliang Shen.  (2023)  Combination therapy to overcome ferroptosis resistance by biomimetic self-assembly nano-prodrug.  Asian Journal of Pharmaceutical Sciences,  (100844).  [PMID:37915761] [10.1016/j.ajps.2023.100844]
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9. Zhenzhen Pan, Qiufang Chen, Xiulan Zheng, Kai Wang, Yalei Duan, Kang Xiao, Zhirong Jia, Xuansheng Ding.  (2023)  JuBei Oral Liquid Induces Mitochondria-Mediated Apoptosis in NSCLC Cells.  OncoTargets and Therapy,  [PMID:32821122] [10.2147/OTT.S254464]
10. Jiabin Zhou, Yuhan Liu, Jun Chen, Nanxiang Xiong, Dongye Yi.  (2023)  Kaempferol suppresses glioma progression and synergistically enhances the antitumor activity of gefitinib by inhibiting the EGFR/SRC/STAT3 signaling pathway.  DRUG DEVELOPMENT RESEARCH,  84  (3): (582-600).  [PMID:36852868] [10.1002/ddr.22048]
11. Yin Xiaoting, Ma Suzhen, Li Mengyuan, Lu Shuaifei, Zhang Changjing, Liu Hui, Li Caiyin, Su Pan, Bai Ming, Li Yucheng.  (2023)  Study on the hepatotoxicity and potential mechanism of gefitinib based on CYP450 in mice and AML12 cells.  JOURNAL OF PHARMACY AND PHARMACOLOGY,  75  (3): (407-414).  [PMID:36656101] [10.1093/jpp/rgac091]
12. Hao Chi, Sheng Tian, Xiu Li, Yuchu Chen, Qiumin Xu, Qixiao Wang, Wenwan Shi, Michael Adu-Frimpong, Shanshan Tong.  (2023)  Construction of lipid raft-coupled agarose gels as bioaffinity chromatography materials and validation with tropomyosin-related kinase A-targeted drugs.  JOURNAL OF CHROMATOGRAPHY A,  1691  (463803).  [PMID:36731332] [10.1016/j.chroma.2023.463803]
13. Jianbo Lin, Rujie Zheng, Liping Huang, Yuanrong Tu, Xu Li, Jianfeng Chen.  (2022)  Folic acid-mediated MSNs@Ag@Geb multifunctional nanocomposite heterogeneous platform for combined therapy of non-small cell lung cancer.  COLLOIDS AND SURFACES B-BIOINTERFACES,  217  (112639).  [PMID:35759894] [10.1016/j.colsurfb.2022.112639]
14. Yulin Jiang, Jing Wang, Juehan Wang, Yi Zhuang, Lin Qi, Ganjun Feng, Li Zhang.  (2022)  Fabrication of novel PNIPAM@GO microspheres loaded with dual drugs featuring on-demand drug release capability.  JOURNAL OF APPLIED POLYMER SCIENCE,  139  (27): (e52444).  [10.1002/app.52444]
15. Pan Zhenzhen, Wang Kai, Wang Xiniao, Jia Zhirong, Yang Yuqi, Duan Yalei, Huang Lianzhan, Wu Zhuo-Xun, Zhang Jian-ye, Ding Xuansheng.  (2022)  Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression.  Molecular Cancer,  21  (1): (1-17).  [PMID:35303882] [10.1186/s12943-022-01547-3]
16. Yan Zhang, Pei Ma, Zhiguang Duan, Yannan Liu, Yu Mi, Daidi Fan.  (2022)  Ginsenoside Rh4 Suppressed Metastasis of Lung Adenocarcinoma via Inhibiting JAK2/STAT3 Signaling.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  23  (4): (2018).  [PMID:35216134] [10.3390/ijms23042018]
17. Yuqin Zhou, Weitong Hu, Xiangli Zhang, Yi Wang, Wenya Zhuang, Fengzhi Li, Qingyong Li.  (2021)  Cellular Uptake and Transport Characteristics of FL118 Derivatives in Caco-2 Cell Monolayers.  CHEMICAL & PHARMACEUTICAL BULLETIN,  69  (11): (1054-1060).  [PMID:34719586] [10.1248/cpb.c21-00467]
18. Fangyin Zhu, Liang Xu, Xudong Li, Ziying Li, Jun Wang, Haijun Chen, Xiumei Li, Yu Gao.  (2021)  Co-delivery of gefitinib and hematoporphyrin by aptamer-modified fluorinated dendrimer for hypoxia alleviation and enhanced synergistic chemo-photodynamic therapy of NSCLC.  EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,  167  (106004).  [PMID:34520834] [10.1016/j.ejps.2021.106004]
19. Zhao-Yang Wang, Hai-Long Wu, Yue-Yue Chang, Tong Wang, Wei Chen, Gao-Yan Tong, Ru-Qin Yu.  (2021)  Simultaneous determination of nine tyrosine kinase inhibitors in three complex biological matrices by using high-performance liquid chromatography–diode array detection combined with a second-order calibration method.  JOURNAL OF SEPARATION SCIENCE,  44  (21): (3914-3923).  [PMID:34463059] [10.1002/jssc.202100293]
20. Tianming Dai, Weifan Jiang, Min Wang, Zizheng Guo, Renke Dai.  (2021)  Influence of two-period cross-over design on the bioequivalence study of gefitinib tablets in beagle dogs.  EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,  165  (105933).  [PMID:34260895] [10.1016/j.ejps.2021.105933]
21. Jiang Yuhong, Zhuo Xin, Fu Xiujuan, Wu Yue, Mao Canquan.  (2021)  Targeting PAR2 Overcomes Gefitinib Resistance in Non-Small-Cell Lung Cancer Cells Through Inhibition of EGFR Transactivation.  Frontiers in Pharmacology,  12  (788).  [PMID:33967759] [10.3389/fphar.2021.625289]
22. Yue-Yue Chang, Hai-Long Wu, Huan Fang, Tong Wang, Yang-Zi Ouyang, Xiao-Dong Sun, Gao-Yan Tong, Yu-Jie Ding, Ru-Qin Yu.  (2021)  Comparison of three chemometric methods for processing HPLC-DAD data with time shifts: Simultaneous determination of ten molecular targeted anti-tumor drugs in different biological samples.  TALANTA,  224  (121798).  [PMID:33379025] [10.1016/j.talanta.2020.121798]
23. Zhixiong Hu, Xin-Yue Jiao, Li Xu.  (2020)  The N,S co-doped carbon dots with excellent luminescent properties from green tea leaf residue and its sensing of gefitinib.  MICROCHEMICAL JOURNAL,  154  (104588).  [10.1016/j.microc.2019.104588]
24. Tianhua Liu, Ling Zuo, Dongqing Guo, Xinlou Chai, Jie Xu, Zhaorui Cui, Zhiyi Wang, Chunying Hou.  (2019)  Ginsenoside Rg3 regulates DNA damage in non-small cell lung cancer cells by activating VRK1/P53BP1 pathway.  BIOMEDICINE & PHARMACOTHERAPY,  120  (109483).  [PMID:31629252] [10.1016/j.biopha.2019.109483]
25. Zhou Leilei, Weng Qi, Zheng Yixin, Zhou Yuqin, Li Qingyong, Li Fengzhi.  (2019)  Uptake and efflux of FL118 and two FL118 derivatives in 3D cell model.  CYTOTECHNOLOGY,  71  (4): (785-795).  [PMID:31309350] [10.1007/s10616-019-00322-5]
26. Weng Qi, Zhou Leilei, Xia Lihua, Zheng Yixin, Zhang Xiangli, Li Fengzhi, Li Qingyong.  (2019)  In vitro evaluation of FL118 and 9-Q20 cytotoxicity and cellular uptake in 2D and 3D different cell models.  CANCER CHEMOTHERAPY AND PHARMACOLOGY,  84  (3): (527-537).  [PMID:31030236] [10.1007/s00280-019-03846-x]
27. Yang Lehe, Lin Shichong, Kang Yanting, Xiang Youqun, Xu Lingyuan, Li Jifa, Dai Xuanxuan, Liang Guang, Huang Xiaoying, Zhao Chengguang.  (2019)  Rhein sensitizes human pancreatic cancer cells to EGFR inhibitors by inhibiting STAT3 pathway.  JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,  38  (1): (1-13).  [PMID:30674340] [10.1186/s13046-018-1015-9]
28. Xuanxuan Dai, Junru Zhang, Guilong Guo, Yuepiao Cai, Ri Cui, Changtian Yin, Weidong Liu, Rajamanickam Vinothkumar, Tingting Zhang, Guang Liang, Xiaohua Zhang.  (2018)  A mono-carbonyl analog of curcumin induces apoptosis in drug-resistant EGFR-mutant lung cancer through the generation of oxidative stress and mitochondrial dysfunction.  Cancer Management and Research,  10  ( 3069–3082).  [PMID:30214301] [10.2147/CMAR.S159660]
29. Guan Huang, Yanli Tong, Qidi He, Jie Wang, Zuanguang Chen.  (2017)  Aucklandia lappa DC. extract enhances gefitinib efficacy in gefitinib-resistance secondary epidermal growth factor receptor mutations.  JOURNAL OF ETHNOPHARMACOLOGY,  206  (353).  [PMID:28619365] [10.1016/j.jep.2017.06.011]
30. Yun-Yun Xi, Qing Tang, Ying Huang, Zhu Tao, Sai-Feng Xue, Qingdi Zhou, Gang Wei.  (2017)  A novel fluorescent indicator displacement assay for sensing the anticancer drug gefitinib.  SUPRAMOLECULAR CHEMISTRY,  [10.1080/10610278.2016.1202413]
31. Peng Mei, Huang Yanjun, Tao Ting, Peng Cai-Yun, Su Qiongli, Xu Wanjun, Darko Kwame Oteng, Tao Xiaojun, Yang Xiaoping.  (2016)  Metformin and gefitinib cooperate to inhibit bladder cancer growth via both AMPK and EGFR pathways joining at Akt and Erk.  Scientific Reports,  6  (1): (1-10).  [PMID:27334428] [10.1038/srep28611]
32. Li Chenjia, Liao Qi, Wang Rui, Zhang Xinping, Ma Mengyang, Liu Yonghong, Xiao Lei, Jiao Ying, Wang Nan.  (2024)  An OPRM1-SNAP-tag/CMC method to directly identify drug components in sewage.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  (1-11).  [PMID:39613988] [10.1007/s00216-024-05672-4]
33. Zhihong Hu, Xixi Hou, Yongjing Ren, Ziyuan Wu, Dong Yan, Hong Chen, Lan Wang.  (2025)  Anti-cancer activity of synthetic gefitinib-1,2,3-triazole derivatives against Hela cells via induction of apoptosis.  Frontiers in Chemistry,  13  [PMID:39926646] [10.3389/fchem.2025.1456743]
34. Wu Yu, Shi Xiao-Jie, Dai Xin-Yi, Song Tian Shun, Li Xiang-Ling, Xie Jing Jing.  (2024)  Biogated mesoporous silica nanoagents for inhibition of cell migration and combined cancer therapy.  MICROCHIMICA ACTA,  191  (6): (1-9).  [PMID:38740583] [10.1007/s00604-024-06401-5]
35. Yuan Liang, Qing Wang, Dianwen Zhang, Yiyao Gong, Qiuyan Jiang, Cong Ma, Libo Si, Tiehua Zhang, Jie Zhang, Zheng Ma.  (2024)  Ginsenoside CK ameliorates tumor growth in lung cancer mice via inhibiting EGFR.  Journal of Functional Foods,  121  (106446).  [10.1016/j.jff.2024.106446]
36. Min Li, Shuaijun Peng, Jingjing Bu, Siqi Quan, Liming Liu, Zhouli Yue, Linlin Wang, Yucheng Li.  (2025)  Glycyrrhizic acid alleviates gefitinib-induced liver injury by regulating the p53/p21 pathway and releasing cell cycle arrest.  FOOD AND CHEMICAL TOXICOLOGY,  200  (115405).  [PMID:40122507] [10.1016/j.fct.2025.115405]
37. Yilan Huang, Siwei Wang, Xiaojun Zhang, Chen Yang, Sikai Wang, Hongxia Cheng, Aiwu Ke, Chao Gao, Kun Guo.  (2024)  Identification of Fasudil as a collaborator to promote the anti-tumor effect of lenvatinib in hepatocellular carcinoma by inhibiting GLI2-mediated hedgehog signaling pathway.  PHARMACOLOGICAL RESEARCH,  200  (107082).  [PMID:38280440] [10.1016/j.phrs.2024.107082]

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