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甘氨酰肌氨酸, 多肽转运体 1；多肽转运体 2

甘氨酰肌氨酸, 多肽转运体 1；多肽转运体 2

2篇引用文献

COA

级别和纯度:

Moligand™

≥98%

CAS编号: 29816-01-1
分子式: C₅H₁₀N₂O₃
分子量: 146.14
Beilstein号: 1768450
EC号: 249-875-2
MDL号: MFCD00038193
PubChem编号: 93131
PubChem SID: 504756172

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库存信息

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货号 (SKU)	包装规格	是否现货
G121423-200mg	200mg	现货
G121423-1g	1g	现货
G121423-5g	5g	现货

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多肽 (100)

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基本描述

英文别名	GLYCINE, GLYCYL-N-METHYL- \| [(ammonioacetyl)(methyl)amino]acetate \| 2JE8SG6VDT \| tritiated glycylsarcosine \| L168049 \| G0138 \| [(Aminoacetyl)(methyl)amino]acetic acid \| 19Z49HUF4G \| GTPL4659 \| GTPL9505 \| N-glycyl-N-methylglycine \| NSC 206288 \| Gly-Sarcosi
规格或纯度	Moligand™, ≥98%
英文名称	Gly-Sar
应用	储存温度: -20°C
储存温度	2-8°C储存
运输条件	冰袋运输
作用机制	多肽转运体 1；多肽转运体 2
产品介绍	Amino Acid Sequence Gly-Sar Amino Acid Sequence Gly-Sar
纯度	≥98%

关联靶点（人）

SLC15A2 Tchem 溶质载体家族 15 成员 2(Solute carrier family 15 member 2) (0 活性数据)

点击查看靶蛋白信息： SLC15A2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

SLC15A1 Tchem 溶质载体家族 15 成员 1(Solute carrier family 15 member 1) (0 活性数据)

点击查看靶蛋白信息： SLC15A1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

SLC15A1 Tchem Oligopeptide transporter small intestine isoform (922 活性数据)

点击查看靶蛋白信息： SLC15A1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Caco-2 (12174 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SLC16A1 Tchem Monocarboxylate transporter 1 (146 活性数据)

点击查看靶蛋白信息： SLC16A1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SLC15A2 Tchem Solute carrier family 15 member 2 (186 活性数据)

点击查看靶蛋白信息： SLC15A2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Slc15a2 Oligopeptide transporter, kidney isoform (114 活性数据)

点击查看靶蛋白信息： Slc15a2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Slc22a5 Solute carrier family 22 member 5 (44 活性数据)

点击查看靶蛋白信息： Slc22a5

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Slc15a1 Solute carrier family 15 member 1 (124 活性数据)

点击查看靶蛋白信息： Slc15a1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

GAP1 General amino-acid permease GAP1 (481 活性数据)

点击查看靶蛋白信息： GAP1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	504756172
EC号	249-875-2
分子类型	小分子
IIUPAC Name	2-[(2-aminoacetyl)-methylamino]acetic acid
INCHI	1S/C5H10N2O3/c1-7(3-5(9)10)4(8)2-6/h2-3,6H2,1H3,(H,9,10)
InChi Key	VYAMLSCELQQRAE-UHFFFAOYSA-N
Smiles	CN(CC(=O)O)C(=O)CN
Isomeric SMILES	CN(CC(=O)O)C(=O)CN
关联CAS	29816-01-1
NSC Number	206288
MeSH Entry Terms	Gly-Sar;glycylsarcosine
分子量	146.14
Beilstein号	1768450
Reaxy-Rn	1768450
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1768450&ln=

化学和物理性质

敏感性	对热敏感
熔点	198-202°C
分子量	146.140 g/mol
XLogP3	-3.900
氢键供体数Hydrogen Bond Donor Count	2
氢键受体数Hydrogen Bond Acceptor Count	4
可旋转键计数Rotatable Bond Count	3
精确质量Exact Mass	146.069 Da
单同位素质量Monoisotopic Mass	146.069 Da
拓扑极表面积Topological Polar Surface Area	83.600 Å²
重原子数Heavy Atom Count	10
形式电荷Formal Charge	0
复杂度Complexity	146.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

WGK Germany	3
个人防护装备	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到8个结果

批号(Lot Number)	证书类型	货号
G2416228	分析证书	G121423
G2416229	分析证书	G121423
A2305185	分析证书	G121423
K2228291	分析证书	G121423
H1421083	分析证书	G121423
D2220069	分析证书	G121423
A2514168	分析证书	G121423
D1423025	分析证书	G121423

此产品的引用文献

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引用文献

1. Jappar D, Wu SP, Hu Y, Smith DE. (2010) Significance and regional dependency of peptide transporter (PEPT) 1 in the intestinal permeability of glycylsarcosine: in situ single-pass perfusion studies in wild-type and Pept1 knockout mice.. Drug Metab Dispos, 38 (10): (1740-6). [PMID:20660104]
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3. Yuri T, Kono Y, Okada T, Terada T, Miyauchi S, Fujita T. (2020) Transport Characteristics of 5-Aminosalicylic Acid Derivatives Conjugated with Amino Acids via Human H⁺-Coupled Oligopeptide Transporter PEPT1.. Biol Pharm Bull, 43 (4): (697-706). [PMID:32238712]
4. Gong Y, Wu X, Wang T, Zhao J, Liu X, Yao Z, Zhang Q, Jian X. (2017) Targeting PEPT1: a novel strategy to improve the antitumor efficacy of doxorubicin in human hepatocellular carcinoma therapy.. Oncotarget, 8 (25): (40454-40468). [PMID:28465466]
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6. Gourdon B, Chemin C, Moreau A, Arnauld T, Baumy P, Cisternino S, Péan JM, Declèves X. (2017) Functionalized PLA-PEG nanoparticles targeting intestinal transporter PepT1 for oral delivery of acyclovir.. Int J Pharm, 529 (1-2): (357-370). [PMID:28705621]
7. Xu X, Sun L, Zhou L, Cheng Y, Cao F. (2020) Functional chitosan oligosaccharide nanomicelles for topical ocular drug delivery of dexamethasone.. Carbohydr Polym, 227 (115356). [PMID:31590850]
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17. Griet Van Zeebroeck,Beatriz Monge Bonini,Matthias Versele,Johan M Thevelein. (2008-12-09) Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.. Nature chemical biology, 5 ((1)): (45-52). [PMID:19060912]
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19. Asdghig H Der-Boghossian,Sara R Saad,Claudine Perreault,Chantale Provost,Danielle Jacques,Lina N Kadi,Nahla G Issa,Abla M Sibai,Nadim W El-Majzoub,Anwar B Bikhazi. (2010-07-24) Role of insulin on jejunal PepT1 expression and function regulation in diabetic male and female rats.. Canadian journal of physiology and pharmacology, 88 ((7)): (753-759). [PMID:20651823]
20. Rafael Gozalbes,Mary Jacewicz,Robert Annand,Katya Tsaioun,Antonio Pineda-Lucena. (2011-04-05) QSAR-based permeability model for drug-like compounds.. Bioorganic & medicinal chemistry, 19 ((8)): (2615-2624). [PMID:21458999]
21. Jeffrey S Scow,Srivats Madhavan,Rizwan M Chaudhry,Ye Zheng,Judith A Duenes,Michael G Sarr. (2011-05-03) Differentiating passive from transporter-mediated uptake by PepT1: a comparison and evaluation of four methods.. The Journal of surgical research, 170 ((1)): (17-23). [PMID:21529830]
22. Dilara Jappar,Yongjun Hu,David E Smith. (2011-09-02) Effect of dose escalation on the in vivo oral absorption and disposition of glycylsarcosine in wild-type and Pept1 knockout mice.. Drug metabolism and disposition: the biological fate of chemicals, 39 ((12)): (2250-2257). [PMID:21880829]
23. Ke Ma,Yongjun Hu,David E Smith. (2011-09-10) Influence of fed-fasted state on intestinal PEPT1 expression and in vivo pharmacokinetics of glycylsarcosine in wild-type and Pept1 knockout mice.. Pharmaceutical research, 29 ((2)): (535-545). [PMID:21904935]
24. Christopher M Leavitt,Arron B Wolk,Michael Z Kamrath,Etienne Garand,Michael J Van Stipdonk,Mark A Johnson. (2011-09-29) Characterizing the intramolecular H-bond and secondary structure in methylated GlyGlyH+ with H2 predissociation spectroscopy.. Journal of the American Society for Mass Spectrometry, 22 ((11)): (1941-1952). [PMID:21952771]
25. Kailas S Khomane,Prajwal P Nandekar,Banrida Wahlang,Pravin Bagul,Naeem Shaikh,Yogesh B Pawar,Chhuttan Lal Meena,Abhay T Sangamwar,Rahul Jain,K Tikoo,Arvind K Bansal. (2012-07-12) Mechanistic insights into PEPT1-mediated transport of a novel antiepileptic, NP-647.. Molecular pharmaceutics, 9 ((9)): (2458-2468). [PMID:22779445]
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27. Megha Barot,Mitan R Gokulgandhi,Dhananjay Pal,Ashim K Mitra. (2012-11-03) Mitochondrial localization of P-glycoprotein and peptide transporters in corneal epithelial cells--novel strategies for intracellular drug targeting.. Experimental eye research, 106 (47-54). [PMID:23116562]
28. Zhiying Wang,Dhananjay Pal,Ashaben Patel,Deep Kwatra,Ashim K Mitra. (2012-12-25) Influence of overexpression of efflux proteins on the function and gene expression of endogenous peptide transporters in MDR-transfected MDCKII cell lines.. International journal of pharmaceutics, 441 ((1-2)): (40-49). [PMID:23262422]
29. Bei Yang,David E Smith. (2012-12-25) Significance of peptide transporter 1 in the intestinal permeability of valacyclovir in wild-type and PepT1 knockout mice.. Drug metabolism and disposition: the biological fate of chemicals, 41 ((3)): (608-614). [PMID:23264448]
30. Steven D Coon,Vazhaikkurichi M Rajendran,John H Schwartz,Satish K Singh. (2014-11-08) Glucose-dependent insulinotropic polypeptide-mediated signaling pathways enhance apical PepT1 expression in intestinal epithelial cells.. American journal of physiology. Gastrointestinal and liver physiology, 308 ((1)): (G56-G62). [PMID:25377315]
31. Mitsuru Tanaka,Seong-Min Hong,Sayaka Akiyama,Qing-Qiang Hu,Toshiro Matsui. (2015-03-27) Visualized absorption of anti-atherosclerotic dipeptide, Trp-His, in Sprague-Dawley rats by LC-MS and MALDI-MS imaging analyses.. Molecular nutrition & food research, 59 ((8)): (1541-1549). [PMID:25808120]
32. Hamed Gilzad Kohan,Kamaljit Kaur,Fakhreddin Jamali. (2015-05-16) Synthesis and characterization of a new Peptide prodrug of glucosamine with enhanced gut permeability.. PloS one, 10 ((5)): (e0126786-e0126786). [PMID:25978315]
33. Tamara Stelzl,Tatjana Baranov,Kerstin E Geillinger,Gabor Kottra,Hannelore Daniel. (2015-11-21) Effect of N-glycosylation on the transport activity of the peptide transporter PEPT1.. American journal of physiology. Gastrointestinal and liver physiology, 310 ((2)): (G128-G141). [PMID:26585416]
34. Su-Jin Kwak,Chu-Sook Kim,Myung-Sook Choi,Taesun Park,Mi-Kyung Sung,Jong Won Yun,Hoon Yoo,Yoshinori Mine,Rina Yu. (2016-06-21) The Soy Peptide Phe-Leu-Val Reduces TNFα-Induced Inflammatory Response and Insulin Resistance in Adipocytes.. Journal of medicinal food, 19 ((7)): (678-685). [PMID:27322965]
35. Hovhannes J Gukasyan,Tomomi Uchiyama,Kwang-Jin Kim,Carsten Ehrhardt,Sharon K Wu,Zea Borok,Edward D Crandall,Vincent H L Lee. (2017-08-24) Oligopeptide Transport in Rat Lung Alveolar Epithelial Cells is Mediated by Pept2.. Pharmaceutical research, 34 ((12)): (2488-2497). [PMID:28831683]
36. Shuping Li,Yunpeng Zhang,Gang Deng,Yuwen Wang,Shenglan Qi,Xuemei Cheng,Yueming Ma,Yan Xie,Changhong Wang. (2017-09-06) Exposure Characteristics of the Analogous β-Carboline Alkaloids Harmaline and Harmine Based on the Efflux Transporter of Multidrug Resistance Protein 2.. Frontiers in pharmacology, 8 (541-541). [PMID:28871225]
37. Claire Colas,Masayuki Masuda,Kazuaki Sugio,Seiji Miyauchi,Yongjun Hu,David E Smith,Avner Schlessinger. (2017-11-08) Chemical Modulation of the Human Oligopeptide Transporter 1, hPepT1.. Molecular pharmaceutics, 14 ((12)): (4685-4693). [PMID:29111754]
38. Benjamin Clémençon,Benjamin P Lüscher,Matthias A Hediger. (2018-03-28) Establishment of a novel microscale thermophoresis ligand-binding assay for characterization of SLC solute carriers using oligopeptide transporter PepT1 (SLC15 family) as a model system.. Journal of pharmacological and toxicological methods, 92 (67-76). [PMID:29580877]
39. Daniel Epling,Yongjun Hu,David E Smith. (2018-06-24) Evaluating the intestinal and oral absorption of the prodrug valacyclovir in wildtype and huPepT1 transgenic mice.. Biochemical pharmacology, 155 (1-7). [PMID:29935147]
40. Hiroshi Arakawa,Hikaru Kubo,Ikumi Washio,Angelina Yukiko Staub,Shiho Nedachi,Naoki Ishiguro,Takeo Nakanishi,Ikumi Tamai. (2019-04-09) Rat Kidney Slices for Evaluation of Apical Membrane Transporters in Proximal Tubular Cells.. Journal of pharmaceutical sciences, 108 ((8)): (2798-2804). [PMID:30959054]
41. Mikihisa Takano,Tomoya Takeuchi,Shiori Kuriyama,Ryoko Yumoto. (2019-05-20) Role of peptide transporter 2 and MAPK signaling pathways in the innate immune response induced by bacterial peptides in alveolar epithelial cells.. Life sciences, 229 (173-179). [PMID:31103606]
42. Yuhuan Chen,Hua Zhang,Lili Mats,Ronghua Liu,Zeyuan Deng,Yoshinori Mine,Rong Tsao. (2019-07-05) Anti-inflammatory Effect and Cellular Uptake Mechanism of Peptides from Common Bean (Phaseolus vulga L.) Milk and Yogurts in Caco-2 Mono- and Caco-2/EA.hy926 Co-culture Models.. Journal of agricultural and food chemistry, 67 ((30)): (8370-8381). [PMID:31271280]
43. Yufeng Zhang,Chunming Lyu,Sophia Yui Kau Fong,Qian Wang,Chenrui Li,Nicolas James Ho,Kay Sheung Chan,Xiaoyu Yan,Zhong Zuo. (2019-07-22) Evaluation of potential herb-drug interactions between oseltamivir and commonly used anti-influenza Chinese medicinal herbs.. Journal of ethnopharmacology, 243 (112097-112097). [PMID:31325600]
44. Ana S Gomes,Francesca Vacca,Raffaella Cinquetti,Koji Murashita,Amilcare Barca,Elena Bossi,Ivar Rønnestad,Tiziano Verri. (2019-10-31) Identification and characterization of the Atlantic salmon peptide transporter 1a.. American journal of physiology. Cell physiology, 318 ((1)): (C191-C204). [PMID:31664857]
45. Yinong Feng,Jiayou Zhang,Yu Miao,Wei Guo,Guangxin Feng,Yisheng Yang,Tengjiao Guo,Haohao Wu,Mingyong Zeng. (2019-12-24) Prevention of Zinc Precipitation with Calcium Phosphate by Casein Hydrolysate Improves Zinc Absorption in Mouse Small Intestine ex Vivo via a Nanoparticle-Mediated Mechanism.. Journal of agricultural and food chemistry, 68 ((2)): (652-659). [PMID:31869222]
46. Yaxian Zheng,Liyun Xing,Liqiang Chen,Rui Zhou,Jiawei Wu,Xi Zhu,Lian Li,Yucheng Xiang,Ruinan Wu,Ling Zhang,Yuan Huang. (2020-09-09) Tailored elasticity combined with biomimetic surface promotes nanoparticle transcytosis to overcome mucosal epithelial barrier.. Biomaterials, 262 (120323-120323). [PMID:32896816]
47. Kazuyoshi Michiba,Kazuya Maeda,Ko Kurimori,Tsuyoshi Enomoto,Osamu Shimomura,Tomoyo Takeuchi,Hiroyuki Nishiyama,Tatsuya Oda,Hiroyuki Kusuhara. (2020-10-23) Characterization of the Human Intestinal Drug Transport with Ussing Chamber System Incorporating Freshly Isolated Human Jejunum.. Drug metabolism and disposition: the biological fate of chemicals, 49 ((1)): (84-93). [PMID:33087448]
48. Pär Matsson,Christel A S Bergström,Naoki Nagahara,Staffan Tavelin,Ulf Norinder,Per Artursson. (2005-01-22) Exploring the role of different drug transport routes in permeability screening.. Journal of medicinal chemistry, 48 ((2)): (604-613). [PMID:15658873]
49. Janet E Simpson,Nancy M Walker,Claudiu T Supuran,Manoocher Soleimani,Lane L Clarke. (2010-02-13) Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium.. American journal of physiology. Gastrointestinal and liver physiology, 298 ((5)): (G683-G691). [PMID:20150244]
50. Mingmin Chen,Anurag Singh,Fang Xiao,Ulrike Dringenberg,Jian Wang,Regina Engelhardt,Sunil Yeruva,Isabel Rubio-Aliaga,Anna-Maria Nässl,Gabor Kottra,Hannelore Daniel,Ursula Seidler. (2010-05-01) Gene ablation for PEPT1 in mice abolishes the effects of dipeptides on small intestinal fluid absorption, short-circuit current, and intracellular pH.. American journal of physiology. Gastrointestinal and liver physiology, 299 ((1)): (G265-G274). [PMID:20430876]
51. Diana Højmark Omkvist,Birger Brodin,Carsten Uhd Nielsen. (2010-08-24) Ibuprofen is a non-competitive inhibitor of the peptide transporter hPEPT1 (SLC15A1): possible interactions between hPEPT1 substrates and ibuprofen.. British journal of pharmacology, 161 ((8)): (1793-1805). [PMID:20726987]
52. Katherine Ma,Yongjun Hu,David E Smith. (2010-09-24) Peptide transporter 1 is responsible for intestinal uptake of the dipeptide glycylsarcosine: studies in everted jejunal rings from wild-type and Pept1 null mice.. Journal of pharmaceutical sciences, 100 ((2)): (767-774). [PMID:20862774]
53. S Frølund,R Holm,B Brodin,C U Nielsen. (2010-10-01) The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics.. British journal of pharmacology, 161 ((3)): (589-600). [PMID:20880398]
54. Wei Wang,Qi Liu,Changyuan Wang,Qiang Meng,Taiichi Kaku,Kexin Liu. (2011-02-12) Effects of JBP485 on the expression and function of PEPT1 in indomethacin-induced intestinal injury in rats and damage in Caco-2 cells.. Peptides, 32 ((5)): (946-955). [PMID:21310202]
55. Hisham G Qandeel,Fernando Alonso,David J Hernandez,Srivats Madhavan,Judith A Duenes,Ye Zheng,Michael G Sarr. (2011-06-08) Peptide absorption after massive proximal small bowel resection: mechanisms of ileal adaptation.. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 15 ((9)): (1537-1547). [PMID:21647767]
56. Xinjin Guo,Qiang Meng,Qi Liu,Changyuan Wang,Huijun Sun,Taiichi Kaku,Kexin Liu. (2012-03-01) Construction, identification and application of HeLa cells stably transfected with human PEPT1 and PEPT2.. Peptides, 34 ((2)): (395-403). [PMID:22369721]
57. Yongjun Hu,Xiaomei Chen,David E Smith. (2012-04-12) Species-dependent uptake of glycylsarcosine but not oseltamivir in Pichia pastoris expressing the rat, mouse, and human intestinal peptide transporter PEPT1.. Drug metabolism and disposition: the biological fate of chemicals, 40 ((7)): (1328-1335). [PMID:22490229]
58. Matthew G Nosworthy,Robert F Bertolo,Janet A Brunton. (2012-12-14) Ontogeny of dipeptide uptake and peptide transporter 1 (PepT1) expression along the gastrointestinal tract in the neonatal Yucatan miniature pig.. The British journal of nutrition, 110 ((2)): (275-281). [PMID:23234698]
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溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度