| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| F656826-1ml |
1ml |
期货  |
|
| 别名 | 非达司他 |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Fidarestat |
| 生化机理 | Fidarestat (SNK 860) 是一种醛糖还原酶抑制剂，对醛糖还原酶、AKR1B10 和 V301L AKR1B10 的 IC 50 s 分别为 26 nM、33 μM 和 1.8 μM；Fidarestat (SNK 860) 具有治疗糖尿病的潜力。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Fidarestat (SNK 860) is an inhibitor of aldose reductase , with IC 50 s of 26 nM, 33 μM, and 1.8 μM for aldose reductase , AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease. In Vitro Fidarestat is an inhibitor of aldose reductase, with IC 50 s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Fidarestat (SNK-860; 1 or 4 mg/kg. p.o., daily for 4 weeks) reduces the concentrations of sorbitol and fructose in diabetic rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 26 nM (Aldose reductase), 33 μM (AKR1B10), 1.8 μM (V301L AKR1B10) |
| 分子类型 | 小分子 |
|---|---|
| Isomeric SMILES | C1[C@H](OC2=C([C@]13C(=O)NC(=O)N3)C=C(C=C2)F)C(=O)N |
| 关联CAS | 136087-85-9 |
| PubChem CID | 160024 |
| MeSH Entry Terms | (2S,4S)-6-fluoro-2',5'-dioxospiro(chroman-4,4'-imidazolidine)-2-carboxamide;fidarestat;SNK 860;SNK-860 |
| 分子量 | 279.22 |
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