Fidarestat

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货号 (SKU)	包装规格	是否现货
F651787-1mg	1mg	期货
F651787-5mg	5mg	期货
F651787-10mg	10mg	期货

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基本描述

别名	非达司他
英文别名	NCGC00167477-01 \| SCHEMBL48827 \| Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2-carboxamide, 2,3-dihydro-2',5'-dioxo-6-fluoro-, (2S-cis)- \| Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2-carboxamide, 6-fluoro-2,3-dihydro-2',5'-dioxo-, (2S-cis)- \| AKOS016011245
规格或纯度	≥99%
英文名称	Fidarestat
生化机理	Fidarestat (SNK 860) 是一种醛糖还原酶抑制剂，对醛糖还原酶、AKR1B10 和 V301L AKR1B10 的 IC 50 s 分别为 26 nM、33 μM 和 1.8 μM；Fidarestat (SNK 860) 具有治疗糖尿病的潜力。
储存温度	-20°C储存
运输条件	超低温冰袋运输
作用类型	抑制剂
产品介绍	Fidarestat (SNK 860) is an inhibitor of aldose reductase , with IC 50 s of 26 nM, 33 μM, and 1.8 μM for aldose reductase , AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease. In Vitro Fidarestat is an inhibitor of aldose reductase, with IC 50 s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Fidarestat (SNK-860; 1 or 4 mg/kg. p.o., daily for 4 weeks) reduces the concentrations of sorbitol and fructose in diabetic rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 26 nM (Aldose reductase), 33 μM (AKR1B10), 1.8 μM (V301L AKR1B10)
纯度	≥99%

AKR1B1 Tclin 醛糖还原酶(Aldose reductase) (7 活性数据)

点击查看靶蛋白信息： AKR1B1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

AKR1B1 Tclin Aldose reductase (1404 活性数据)

点击查看靶蛋白信息： AKR1B1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

AKR1A1 Tchem Aldehyde reductase (91 活性数据)

点击查看靶蛋白信息： AKR1A1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Akr1c21 Aldo-keto reductase family 1 member C21 (12 活性数据)

点击查看靶蛋白信息： Akr1c21

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

分子类型	小分子
IIUPAC Name	(2S,4S)-6-fluoro-2',5'-dioxospiro[2,3-dihydrochromene-4,4'-imidazolidine]-2-carboxamide
INCHI	1S/C12H10FN3O4/c13-5-1-2-7-6(3-5)12(4-8(20-7)9(14)17)10(18)15-11(19)16-12/h1-3,8H,4H2,(H2,14,17)(H2,15,16,18,19)/t8-,12-/m0/s1
InChi Key	WAAPEIZFCHNLKK-UFBFGSQYSA-N
Smiles	C1C(OC2=C(C13C(=O)NC(=O)N3)C=C(C=C2)F)C(=O)N
Isomeric SMILES	C1[C@H](OC2=C([C@]13C(=O)NC(=O)N3)C=C(C=C2)F)C(=O)N
关联CAS	136087-85-9
PubChem CID	160024
MeSH Entry Terms	(2S,4S)-6-fluoro-2',5'-dioxospiro(chroman-4,4'-imidazolidine)-2-carboxamide;fidarestat;SNK 860;SNK-860
分子量	279.22

溶解性	DMSO : 250 mg/mL (895.35 mM; Need ultrasonic)
分子量	279.220 g/mol
XLogP3	-0.300
氢键供体数Hydrogen Bond Donor Count	3
氢键受体数Hydrogen Bond Acceptor Count	5
可旋转键计数Rotatable Bond Count	1
精确质量Exact Mass	279.066 Da
单同位素质量Monoisotopic Mass	279.066 Da
拓扑极表面积Topological Polar Surface Area	111.000 Å²
重原子数Heavy Atom Count	20
形式电荷Formal Charge	0
复杂度Complexity	485.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	2
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1