菲律宾菌素复合体

Antibiotics Disease Research Antifungal Antibiotics Disease Research Antiviral Antibiotics Other Antibiotics

3篇引用文献

COA

级别和纯度:

Moligand™

≥97%(mixture)

CAS编号: 11078-21-0
分子式: C₃₅H₅₈O₁₁ (for Filipin III)
分子量: 654.80
EC号: 631-260-9,637-175-3
PubChem编号: 6433194

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货号 (SKU)	包装规格	是否现货
F650764-5mg	5mg	现货
F650764-10mg	10mg	现货
F650764-50mg	50mg	现货

查看相关系列

Anti-infection (2804) Antibiotic (2632) Antibiotics Disease Research Antifungal Antibiotics Disease Research Antiviral Antibiotics Other Antibiotics (2) Fungal (1689)

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基本描述

别名	非律平
英文别名	1',26-dihydroxyfilipin \| U-5956 \| Filimarisin \| TK-336 \| NSC3364 \| NSC-3364 \| 14-Deoxylagosin \| FILIPIN DERIVATIVE \| 1'-epi-filipin iv \| GUDVQJXODNJRIJ-CALCHBBNSA-N \| 4,6,8,10,12,14,16,27-Octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyl-oxacyclooctacosa-17,1
规格或纯度	Moligand™, ≥97%(mixture)
英文名称	Filipin complex
生化机理	Filipin 复合物是一种强效的多烯类大环内酯抗真菌抗生素。Filipin 复合物可插入膜中，将胆固醇螯合成复合物，抑制 PRRSV 的进入。Filipin 复合物由 70% 的 filipin III（HY-N6718）和 5% 的其他 filipin 同源物组成。
储存温度	避光,-20°C储存,充氩
运输条件	超低温冰袋运输
产品介绍	A complex of polyene (pentaene) macrocyclic lactones antibiotics obtained from Streptomyces filipinensis. Filipin complex is a potent broad spectrum antifungal agent that also exhibits antitumor and antiviral activities. Filipin complex acts by binding cell membrane sterols, disrupting membrane integrity.inhibits mitochondrial respiration.Filipin III is the most abundant component of the bulk complex (>>70%) of the complex. In Vitro Filipin complex (2 μg/ml; 1+48 h) inhibits PRRSV entry with respiratory syndrome virus (PRRSV) genome copies in infected cells reduced by 61% in MARC-145 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Macrolide
纯度	≥97%(mixture)

关联靶点（人）

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 活性数据)

点击查看靶蛋白信息： SLCO1B1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 活性数据)

点击查看靶蛋白信息： SLCO1B3

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Escherichia coli (133304 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Saccharomyces cerevisiae (19171 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Bacillus cereus (7522 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Candida albicans (78123 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Penicillium digitatum (260 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Colletotrichum (56 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Botrytis (43 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Beauveria bassiana (27 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

EC号	631-260-9, 637-175-3
分子类型	小分子
IIUPAC Name	(3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,16,27-octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one
INCHI	1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-/m1/s1
InChi Key	IMQSIXYSKPIGPD-YQRUMEKGSA-N
Smiles	CCCCCC(C1C(CC(CC(CC(CC(CC(CC(C(=CC=CC=CC=CC=CC(C(OC1=O)C)O)C)O)O)O)O)O)O)O)O
Isomeric SMILES	CCCCC[C@H]([C@@H]1[C@H](C[C@H](C[C@H](C[C@H](C[C@H](C[C@H](C[C@@H](/C(=C/C=C/C=C/C=C/C=C/[C@@H]([C@H](OC1=O)C)O)/C)O)O)O)O)O)O)O)O
关联CAS	11078-21-0,480-49-9
MeSH Entry Terms	Desoxylagosin;Filimarisin;Filipin;Filipin I;Filipin II;Filipin III;Filipin IV;NSC 3364;NSC-3364;NSC3364;U 5956;U-5956;U5956
分子量	654.80
Reaxy-Rn	1339814
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1339814&ln=

化学和物理性质

溶解性	DMSO : ≥ 100 mg/mL (152.72 mM) Ethanol : 10 mg/mL (15.27 mM; ultrasonic and warming and heat to 60°C)
敏感性	对光敏感
分子量	654.800 g/mol
XLogP3	3.200
氢键供体数Hydrogen Bond Donor Count	9
氢键受体数Hydrogen Bond Acceptor Count	11
可旋转键计数Rotatable Bond Count	5
精确质量Exact Mass	654.398 Da
单同位素质量Monoisotopic Mass	654.398 Da
拓扑极表面积Topological Polar Surface Area	208.000 Å²
重原子数Heavy Atom Count	46
形式电荷Formal Charge	0
复杂度Complexity	991.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	11
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	5
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	5
共价键合单元计数Covalently-Bonded Unit Count	1

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到6个结果

批号(Lot Number)	证书类型	货号
B2510514	分析证书	F650764
B2510516	分析证书	F650764
B2510525	分析证书	F650764
B2510512	分析证书	F650764
B2510513	分析证书	F650764
B2510515	分析证书	F650764

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引用文献

1. Jianbo Li, Yaru Xu, Jieke Zhang, Qinglian Li, Chenxu Wang, Zhe Wu, Weijing Yang, Meng Xu, Zhenzhong Zhang, Lei Wang, Jinjie Zhang. (2023) Bioinspired fine-tuning of the mechanical rigidity of SNEDDS for the efficient crossing of multiple gastrointestinal barriers. JOURNAL OF CONTROLLED RELEASE, 362 (170). [PMID:37625600] [10.1016/j.jconrel.2023.08.044]
2. Peifu Xiao, Xiaoguang Tao, Hanxun Wang, Hongbing Liu, Yupeng Feng, Yueqi Zhu, Zhengzhen Jiang, Tian Yin, Yu Zhang, Haibing He, Jingxin Gou, Xing Tang. (2023) Enzyme/pH dual stimuli-responsive nanoplatform co-deliver disulfiram and doxorubicin for effective treatment of breast cancer lung metastasis. Expert Opinion on Drug Delivery, 20 (7): (1015-1031). [PMID:37452715] [10.1080/17425247.2023.2237888]
3. Dan Li, Gaoyang Yi, Guifang Cao, Adam C. Midgley, Yongli Yang, Dan Yang, Wenguang Liu, Yujuan He, Xiaolin Yao, Guoliang Li. (2025) Dual-Carriers of Tartary Buckwheat-Derived Exosome-Like Nanovesicles Synergistically Regulate Glucose Metabolism in the Intestine-Liver Axis. Small, (2410124). [PMID:40079102] [10.1002/smll.202410124]

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