FIDAS-5

COA

级别和纯度:

≥98%

CAS编号: 1391934-98-7
分子式: C₁₅H₁₃ClFN
分子量: 261.72
PubChem编号: 57521314

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货号 (SKU)	包装规格	是否现货
F649416-1mg	1mg	期货
F649416-5mg	5mg	期货
F649416-10mg	10mg	期货
F649416-50mg	50mg	期货
F649416-100mg	100mg	期货
F649416-250mg	250mg	期货

查看相关系列

Amino Acid/Protein Metabolism (4559) Histone Modification (3105) Metabolic Enzyme/Protease (4889) Methionine Adenosyltransferase (MAT) (13) 表观遗传学 (1497)

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基本描述

规格或纯度	≥98%
英文名称	FIDAS-5
生化机理	FIDAS-5 是一种强效的蛋氨酸 S-腺苷转移酶 2A（MAT2A）口服活性抑制剂，IC50 为 2.1 μM。FIDAS-5 能有效竞争 S-腺苷蛋氨酸（SAM）与 MAT2A 的结合。FIDAS-5 具有抗癌活性。
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC 50 of 2.1 μM. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities In Vitro FIDAS-5 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells. ?\nFIDAS-5 (3 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells. And FIDAS-5 induces the expression of cell cycle inhibitor, p21 WAF1/CIP1. ?\nFIDAS-5 (3 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: LS174T colorectal cancer (CRC) cells Concentration: 3 μM Incubation Time: 7 days Result: Significantly inhibited the proliferation of LS174T cells. In Vivo FIDAS-5 (20 mg/kg; oral gavage; daily; for two weeks; athymic nude mice) treatment significantly inhibits the growth of xenograft tumors, with minimal difference in body weight . ?\nMice are treated with FIDAS-5 (20 mg/kg) for 1 week. The liver SAM levels are significantly reduced . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 16 athymic nude mice injected with HT29 CRC cells Dosage: 20 mg/kg Administration: Oral gavage; daily; for two weeks Result: Significantly inhibited the growth of xenograft tumors. Form:Solid IC50& Target:IC50: 2.1 μM (Methionine S-adenosyltransferase 2A (MAT2A))
纯度	≥98%

关联靶点（人）

KCNH2 Tclin HERG (29587 活性数据)

点击查看靶蛋白信息： KCNH2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

分子类型	小分子
IIUPAC Name	4-[(E)-2-(2-chloro-6-fluorophenyl)ethenyl]-N-methylaniline
INCHI	1S/C15H13ClFN/c1-18-12-8-5-11(6-9-12)7-10-13-14(16)3-2-4-15(13)17/h2-10,18H,1H3/b10-7+
InChi Key	KXVXICBOMOGFMH-JXMROGBWSA-N
Smiles	CNC1=CC=C(C=C1)C=CC2=C(C=CC=C2Cl)F
Isomeric SMILES	CNC1=CC=C(C=C1)/C=C/C2=C(C=CC=C2Cl)F
PubChem CID	57521314
分子量	261.72

化学和物理性质

溶解性	DMSO : 125 mg/mL (477.61 mM; Need ultrasonic)
分子量	261.720 g/mol
XLogP3	4.900
氢键供体数Hydrogen Bond Donor Count	1
氢键受体数Hydrogen Bond Acceptor Count	2
可旋转键计数Rotatable Bond Count	3
精确质量Exact Mass	261.072 Da
单同位素质量Monoisotopic Mass	261.072 Da
拓扑极表面积Topological Polar Surface Area	12.000 Å²
重原子数Heavy Atom Count	18
形式电荷Formal Charge	0
复杂度Complexity	274.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	1
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	1
共价键合单元计数Covalently-Bonded Unit Count	1

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